A5068595836- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Heart Failure Treatment and Management
- Non-Invasive Vital Sign Monitoring
- Ion channel regulation and function
- Congenital Heart Disease Studies
- Immune cells in cancer
- Cardiac Health and Mental Health
- EEG and Brain-Computer Interfaces
- Cardiac Imaging and Diagnostics
- Liver Diseases and Immunity
- Immune Cell Function and Interaction
- Health Literacy and Information Accessibility
- Sympathectomy and Hyperhidrosis Treatments
- Immune Response and Inflammation
- Transplantation: Methods and Outcomes
- Hypertrophic osteoarthropathy and related conditions
Medizinische Hochschule Hannover
2017-2025
Kepler Universitätsklinikum
2021
Centre Hospitalier Universitaire de Clermont-Ferrand
2021
Hochschule Hannover
2020
Universitätsklinikum Würzburg
2015
University Hospital of Bern
2014
University of Bern
2014
The goal of this study was to develop a risk score model for patients with Brugada syndrome (BrS).Risk stratification in BrS is significant challenge due the low event rates and conflicting evidence.A multicenter international cohort no previous cardiac arrest used evaluate role 16 proposed clinical or electrocardiogram (ECG) markers predicting ventricular arrhythmias (VAs)/sudden death (SCD) during follow-up. Predictive were incorporated into model, validated by using out-of-sample...
Natural language processing chatbots (NLPC) can be used to gather information for medical content. However, these tools contain a potential risk of misinformation. This study aims evaluate different aspects responses given by NLPCs on questions about atrial fibrillation (AF) and clinical implantable electronic devices (CIED).
Abstract Background The QRS axis of the electrocardiogram (ECG) is often considered in clinical practice, but its determination frequently limited to a rough estimation, such as “normal”, with left or right deviation, and superior inferior case premature ventricular complexes (PVCs). However, more exact may be warranted certain scenarios, determine origin PVCs precisely, attainable by visual estimation using hexaxial reference system. Objectives aim this study was how well an would correlate...
Abstract Aims To analyse the predictive value of advanced markers right ventricular (RV) function and RV‐pulmonary arterial (PA) coupling in forecasting long‐term left (LV) improvement de novo heart failure with reduced ejection fraction (HFrEF). Methods results 260 patients (mean age 57 years, 68% men) from PROLONG‐II study were included. analysed new‐onset HFrEF receiving a wearable cardioverter‐defibrillator. For this substudy, RV free wall longitudinal strain (RVFWS), tricuspid annular...
Abstract Background Autonomic nervous system activation plays an important role in the pathophysiology of atrial fibrillation. It can be determined using heart rate variability. We aimed to evaluate feasibility photoplethysmography recordings for assessment ultra-short-term Methods TeleCheck-AF is a structured mobile health approach, comprising on-demand use photoplethysmography-based smartphone application prior scheduled teleconsultation ensure comprehensive remote fibrillation management....
Abstract Aims Patients with adult congenital heart disease (ACHD) carry an increased risk for sudden cardiac death. Implantable cardioverter‐defibrillator (ICD) therapy may be challenging in these patients due to anatomical barriers, repeated surgery, or complicated transvenous access. Thus, the subcutaneous ICD (S‐ICD) can a promising alternative this patient population. ACHD show significant electrocardiogram (ECG) abnormalities, which could affect S‐ICD sensing because it depends on...
The wearable cardioverter-defibrillator (WCD) is used for temporary protection from sudden cardiac death (SCD) in patients with newly diagnosed heart failure reduced ejection fraction before considering an implantable (ICD). However, the prognostic significance of WCD remains controversial due to conflicting evidence. aim present study was evaluate prognosis receiving life-saving shocks.
In patients with unexplained syncope, implantable loop recorders (ILR) are used to detect arrhythmias as a cause of syncope. This study aimed assess the diagnostic yield and clinical implications arising from ILR implantation in syncope Germany. Secondary longitudinal data were obtained large German research database including anonymized nationwide statutory health insurances, representative for population. Patients ≥ 18 years diagnosis between 2017 2018 analyzed, cardiac diagnoses therapies...
Invasive aspergillosis is a devastating infectious disease in immunocompromised patients. Besides neutrophils and macrophages, natural killer (NK) cells have recently emerged as important players immunity to this infection. It was shown that NK comprise an essential role the clearance of Aspergillus fumigatus ( A. ) neutropenic but not nonneutropenic mice. However, antifungal activity their regulation been fully characterized. In study, we investigated interplay between polymorphonuclear...
In patients with newly diagnosed heart failure reduced ejection fraction (HFrEF), three months of optimal therapy are recommended before considering a primary preventive implantable cardioverter-defibrillator (ICD). It is unclear which benefit from prolonged waiting period under protection the wearable (WCD) to avoid unnecessary ICD implantations. This study included all receiving WCD for HFrEF (
Abstract Aim The implementation of 3D mapping systems plays an important role in interventional electrophysiology (EP) recent years. aim the present study was to evaluate use regarding fluoroscopy and procedure duration. Method In “Go for Zero Fluoroscopy” project 25 European centers provided data consecutive EP procedures. Data on as well utilization contact force catheters multipolar were associated with time, dose area product (DAP), Result A system used 966 (54%) cases. Use...
The wearable cardioverter-defibrillator (WCD) is used in patients with newly diagnosed heart failure and reduced ejection fraction (HFrEF). In addition to arrhythmic events, the WCD provides near-continuous telemetric monitoring. purpose of this study was evaluate clinical relevance additionally recorded parameters, such as rate or step count. We included HFrEF prescribed a WCD. Via WCD, count were acquired, an approximate for variability (HRV5) calculated. Multivariate analysis performed...
Abstract Introduction In patients with a left ventricular assist device (LVAD), the subcutaneous implantable cardioverter‐defibrillator (S‐ICD) can be an alternative to transvenous ICD systems due reduced risk of systemic infection, which could lead extraction as well LVAD. S‐ICD eligibility is lower in LVAD than end‐stage heart failure without Several reports have shown inappropriate therapy coexistence and S‐ICD. The aim present study was evaluate using established electrocardiogram...
Abstract Purpose The subcutaneous implantable cardioverter-defibrillator (S-ICD) could be a promising alternative to the conventional transvenous ICD in patients with LVAD due its reduced risk of infection. However, surface ECG is altered following implantation and, since S-ICD detection based on ECG, potentially affected. aim present study was analyze eligibility LVAD. Methods Seventy-five implanted an were included this prospective single-center study. ECG-based screening test and...
Brugada syndrome (BrS) is an inherited arrhythmia associated with increased risk of sudden cardiac death. SCN5A the most important disease-modifying gene for BrS, but many variants have not been functionally characterized. Furthermore, temperature dependency only rarely explored in vitro analyses.The clinical phenotype affected family was assessed by medical history, ECGs and ajmaline challenge. Whole-cell patch clamp recordings were performed on HEK 293T cells expressing Nav1.5-G1712S, a...
Temporary transvenous pacing in critically ill patients requiring prolonged cardiac is associated with a high risk of complications. We sought to evaluate the safety and efficacy self-contained intracardiac leadless pacemaker (LPM) implantation this population.Consecutive implanted Micra LPM during hospitalization an intensive care unit were retrospectively included. Inclusion criteria were: more than or equal 1 supracaval central venous line, ventilation tube, intravenous antibiotic therapy...
Implantation of left ventricular assist devices (LVAD) has become an important treatment strategy for patients with end-stage heart failure to improve survival and reduce morbidity.1 As increased susceptibility arrhythmias is associated failure, many have implantable cardioverter-defibrillators (ICD) or receive ICD implantation after LVAD implantation.2 This coexistence 2 neighboring implanted electrical increases the risk relevant device-device interactions.