A5103094893- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Cancer Treatment and Pharmacology
- Estrogen and related hormone effects
- Prostate Cancer Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Radiomics and Machine Learning in Medical Imaging
- Chronic Lymphocytic Leukemia Research
- Dialysis and Renal Disease Management
- Advanced Breast Cancer Therapies
- Natural product bioactivities and synthesis
- Diabetes Treatment and Management
- Molecular spectroscopy and chirality
- Cancer Genomics and Diagnostics
- Mass Spectrometry Techniques and Applications
- Epigenetics and DNA Methylation
- Medical Imaging Techniques and Applications
- Traditional and Medicinal Uses of Annonaceae
- Advanced NMR Techniques and Applications
- Biological Stains and Phytochemicals
- Analytical Chemistry and Chromatography
- Diabetes Management and Education
- Statistical Methods in Clinical Trials
Janssen (United States)
2015-2024
Massachusetts Institute of Technology
2024
Vassar College
2024
Stanford University
2018-2023
Fidelity Investments (United States)
2023
Springhouse
2022
University of Colorado Denver
2021
Medical College of Wisconsin
2021
National Jewish Health
2021
Janssen (Belgium)
2013-2019
Apalutamide is an inhibitor of the ligand-binding domain androgen receptor. Whether addition apalutamide to androgen-deprivation therapy (ADT) would prolong radiographic progression–free survival and overall as compared with placebo plus ADT among patients metastatic, castration-sensitive prostate cancer has not been determined.
Apalutamide, a competitive inhibitor of the androgen receptor, is under development for treatment prostate cancer. We evaluated efficacy apalutamide in men with nonmetastatic castration-resistant cancer who were at high risk metastasis.We conducted double-blind, placebo-controlled, phase 3 trial involving and prostate-specific antigen doubling time 10 months or less. Patients randomly assigned, 2:1 ratio, to receive (240 mg per day) placebo. All patients continued androgen-deprivation...
Apalutamide is a potent androgen receptor (AR) antagonist that targets the AR ligand-binding domain and prevents nuclear translocation, DNA binding, transcription of gene targets. To evaluate activity safety apalutamide in patients with high-risk nonmetastatic castration-resistant prostate cancer (nmCRPC). We conducted multicenter phase 2 study nmCRPC high risk for progression (prostate-specific antigen [PSA] ≥8 ng/ml or PSA doubling time [PSA DT] ≤10 mo). Patients received 240 mg/d while...
Abstract Food effect on abiraterone pharmacokinetics and safety acetate coadministration with low‐fat or high‐fat meals was examined in healthy subjects metastatic castration‐resistant prostate cancer (mCRPC) patients. Healthy (n = 36) were randomized to (single dose, 1000 mg) + meal, fasted state. mCRPC patients received repeated doses (abiraterone mg 5 prednisone twice daily; days 1–7) a modified fasting state followed by plus within 0.5 hours post–low‐fat 6) meal 18; 8–14). In subjects,...
Attomole quantities of 4-(dimethylamino)azobenzene-4'-sulfonyl chloride derivatized amino acids are separated by using capillary zone electrophoresis in a mixed acetonitrile/aqueous buffer system. Detection is performed with an on-column thermooptical absorbance detection technique based on 130-mW argon ion pump laser. limits for the concentration analyte injected onto column range from 5 x 10(-8) M methionine to 10(-7) aspartic acid. Only 37 amol and 450 acid contained within subnanoliter...
<b><i>Background/Aims:</i></b> Women with diabetes experience a disproportionately greater burden of diabetic kidney disease (DKD) risk factors compared to men; however, sex-specific differences in DKD are not well defined. The effect age on sex is unknown. <b><i>Methods:</i></b> We performed cross-sectional analysis the prevalence (eGFR <60 ml/min/1.73 m<sup>2</sup> or microalbuminuria), advanced <30...
Purpose: To evaluate the efficacy of apalutamide before or after treatment with abiraterone acetate and prednisone (AAP) in patients progressive metastatic castration-resistant prostate cancer (mCRPC).Experimental Design: Two cohorts were studied: AAP-naïve post-AAP who had received ≥6 months AAP. Patients mCRPC per rising prostate-specific antigen (PSA) and/or imaging, without prior chemotherapy exposure. All 240 mg/day. Primary endpoint was ≥50% decline 12-week PSA according to Prostate...
Chronic supraphysiological glucocorticoid therapy controls the androgen excess of 21-hydroxylase deficiency (21OHD) but contributes to high prevalence obesity, glucose intolerance, and reduced bone mass in these patients. Abiraterone acetate (AA) is a prodrug for abiraterone, potent CYP17A1 inhibitor used suppress androgens treatment prostate cancer.The objective study was test hypothesis that AA added physiological hydrocortisone 9α-fludrocortisone corrects women with 21OHD without causing...
Abstract Purpose: We constructed a biomarker-survival modeling framework to explore the relationship between prostate-specific antigen (PSA) kinetics and overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients following oral administration of 1,000 mg/day abiraterone acetate (AA). Experimental Design: The PSA-survival was based on data from two phase III studies, COU-AA-301 (chemotherapy pretreated, n = 1,184) COU-AA-302 naïve, 1,081), included mixed-effects...
Androgen receptor (AR) signaling and incomplete inhibition of estrogen may contribute to metastatic breast cancer (MBC) resistance a nonsteroidal aromatase inhibitor (NSAI; letrozole or anastrozole). We assessed whether combined androgen biosynthesis with abiraterone acetate plus prednisone estradiol synthesis exemestane (E) be clinical benefit postmenopausal patients NSAI-pretreated receptor-positive (ER+) MBC. Patients (N = 297) were stratified by the number prior therapies for disease...
Patients with chronic diabetic complications experience high morbidity and mortality. Sex disparities in modifiable factors such as processes of care or self-care activities have not been explored detail, particularly these high-risk patients. differences were assessed a cross-sectional analysis the Pathways Study, an observational cohort primary patients from managed organization (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Aim Women with diabetes have a higher prevalence of chronic kidney disease ( CKD ) risk factors compared men, but whether they are at for incident remains uncertain. Methods This was prospective, observational cohort study 1464 patients and normal renal function, recruited from primary care clinics vertically integrated healthcare system in S eattle, WA , USA . The predictor sex. Incident defined by an estimated glomerular filtration rate eGFR <60 mL/min per 1.73 m 2 Chronic...
<h3>Importance</h3> There is a need to identify prognostic biomarkers guide treatment intensification in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC). <h3>Objective</h3> To examine whether molecular subtypes predict response apalutamide, using archived primary tumor samples from the randomized, double-blind, phase 3 SPARTAN trial. <h3>Design, Setting, and Participants</h3> In this cohort study, gene expression data 233 nmCRPC enrolled trial were generated human...
Comorbid major depression is associated with adverse health outcomes in patients diabetes, but little known regarding its associations long-term renal this population. Furthermore, the impact of minor on not known. This study evaluated between depressive symptoms and risk incident ESRD a diabetic cohort.In prospective, observational cohort study, 3886 ambulatory adults diabetes were recruited from primary care clinics large maintenance organization state Washington. Demographics, laboratory...
Whether secular trends in eGFR at dialysis initiation reflect changes clinical presentation over time is unknown. We reviewed the medical records of a random sample patients who initiated maintenance Department Veterans Affairs (VA) fiscal years 2000-2009 (n=1691) to characterize relation initiation. Between 2000-2004 and 2005-2009, mean increased from 9.8±5.8 11.0±5.5 ml/min per 1.73 m(2) (P<0.001), percentage with an 10-15 23.4% 29.9% (P=0.002), eGFR>15 12.1% 16.3% (P=0.01). The proportion...
It is demonstrated that HSQC gives considerably better 13C resolution and sensitivity than HMQC for CH2 groups of natural products, particularly when combined with linear prediction. Similarly, coupled spectra provide a useful method the determination 1H multiplet structure consequent assignment individual protons as axial or equatorial in fused cyclohexane rings. These related techniques are used to assign marine sterol clionasterol. © 1997 John Wiley & Sons, Ltd.