A5019944823- Adipose Tissue and Metabolism
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Diverse Aspects of Tourism Research
- Cancer, Hypoxia, and Metabolism
- Sport and Mega-Event Impacts
- Cruise Tourism Development and Management
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Thermoregulation and physiological responses
- Regulation of Appetite and Obesity
Czech Academy of Sciences
2021-2024
Czech Academy of Sciences, Institute of Physiology
2021-2024
Charles University
2023-2024
Non-shivering thermogenesis (NST) mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) can be activated via the adrenergic system response to cold or diet, contributing both thermal and energy homeostasis. Other mechanisms, including metabolism of skeletal muscle, may also involved NST. However, relative contribution these dissipating pathways their adaptability remain a matter long-standing controversy.We used warm-acclimated (30 °C) mice characterize effect an up 7-day...
Fibroblast growth factor 21 (FGF21) reduces body weight, which was attributed to induced energy expenditure (EE). Conflicting data have been published on the role of uncoupling protein 1 (UCP1) in this effect. Therefore, we aimed revisit thermoregulatory effects FGF21 and their implications for weight regulation. We found that an 8-day treatment with lowers similar extent both wildtype (WT) UCP1-deficient (KO) mice fed high-fat diet. In WT mice, effect is solely due increased EE, associated...
Administration of FGF21 to mice reduces body weight and increases temperature. The increase in temperature is generally interpreted as hyperthermia, i.e. a condition secondary the energy expenditure (heat production). Here, we examine an alternative hypothesis: that has direct pyrexic effect, independently any effect on expenditure.We studied effects treatment high-fat-diet-fed chow-fed exposed acutely various ambient temperatures, high-fat diet-fed housed at 30 °C (i.e. thermoneutrality),...
The postnatal surge in circulating leptin levels mice reflects particularly posttranscriptionally controlled release of this hormone from subcutaneous white adipose tissue. Leptinemia 2-wk-old pups predicts both body weight and adiposity adult fed a high-fat diet. extent these effects depends on genetically determined differences propensity to obesity between C57BL/6 A/J mice. effect is compromised the obesity-prone
Fibroblast growth factor 21 (FGF21) reduces body weight, which was attributed to induced energy expenditure (EE). Conflicting data have been published on the role of uncoupling protein 1 (UCP1) in this effect. Therefore, we aimed revisit thermoregulatory effects FGF21 and their implications for weight regulation. We found that an 8-day treatment with lowers similar extent both wild-type (WT) UCP1-deficient (KO) mice fed high-fat diet. In WT mice, effect is solely due increased EE, associated...