A5032076072- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Bone fractures and treatments
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Endometrial and Cervical Cancer Treatments
- Membrane Separation Technologies
- Estrogen and related hormone effects
- Hip and Femur Fractures
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Orthopaedic implants and arthroplasty
- Reconstructive Surgery and Microvascular Techniques
- Cancer Mechanisms and Therapy
- Parasites and Host Interactions
- Cancer Risks and Factors
- Periodontal Regeneration and Treatments
- Immune cells in cancer
- Endometriosis Research and Treatment
Harbin Institute of Technology
2022-2025
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2025
Nanjing Medical University
2013-2024
Jiangsu Province Hospital
2012-2024
Mongolian National University
2024
Wuhan University
2018-2023
Huazhong University of Science and Technology
2010-2023
Ministry of Natural Resources
2023
Nanjing Tech University
2023
Wuhan Puai Hospital
2019-2021
N6-methyladenosine (m
Although many studies have confirmed the relationship between obesity and endometrial cancer (EC), molecular mechanism EC progression has not been elucidated. Overexpression of fat mass associated protein FTO leads to weight gain, although recently it discovered that can serve as a demethylase which erases N6-methyladenosine (m6A) modification regulates metabolization mRNAs. In this study, we found high expression in metastatic action promote both metastasis invasion vivo vitro....
Methylation is the main form of RNA modification. N6-methyladenine (m6A) regulates splicing and translation mRNA. Alk B homologue 5 (ALKBH5) participates in biological regulation various cancers. However, its role ovarian carcinogenesis has not been unveiled. In present study, ALKBH5 showed higher expression cancer tissue than normal tissue, but lower cell lines lines. Interestingly, Toll-like receptor (TLR4), a molecular functioning tumour microenvironment (TME), demonstrated same trend. To...
Abstract Cervical cancer is the fourth most common malignancy in women worldwide and cervical squamous cell carcinoma (CESC) histological type of cancer. The dysregulation genes plays a significant role In present study, we screened out differentially expressed (DEGs) CESC GSE63514 data set from Gene Expression Omnibus database. An integrated bioinformatics analysis was used to select hub genes, as well investigate their related prognostic signature, functional annotation, methylation...
Abstract Endometrial cancer (EC) is a fatal female reproductive tumor. Bioinformatic tools are increasingly developed to screen out molecular targets related EC. In this study, GSE17025 and GSE40032 were obtained from Gene Expression Omnibus (GEO). “limma” package Venn diagram tool used identify hub genes. FunRich was for functional analysis. Retrieval of Interacting Genes Database (STRING) analyze protein‐protein interaction (PPI) complex. Cancer Genome Atlas (TCGA), GEPIA,...
Endometrial cancer is the fourth most common in women. The death rate for endometrial has increased. Glycolysis of cellular respiration a complex reaction and first step carbohydrate catabolism, which was proved to participate tumors.We analyzed sample data over 500 patients from TCGA database. bioinformatic analysis included GSEA, cox lasso regression select prognostic genes, as well construction model nomogram OS evaluation. immunohistochemistry staining, survival expression level...
In this study, we devoted to investigate immune-related genes and tumor microenvironment (TME) in EC based on The Cancer Genome Atlas (TCGA) database. total 799 up-regulated 139 down-regulated differentially expressed were investigated for functional annotations prognosis. By a conjoint Cox regression analysis, built two risk models OS DFS, as well the consistent nomograms. Immune-related pathways revealed mostly enriched low-risk group. further analyzing TME signatures, higher immune cell...
Most of the residents’ daily travel is concentrated within their 15-min walking distance. In China, derived from city concept, walkable area often referred to as pedestrian-scale neighborhood, and it has become a basic planning unit. Understanding factors that influence built environment neighborhood on carbon emissions critical reduce urban emissions. There may be spatial heterogeneity in dependent variable due factors. Therefore, this study used data Wuhan City Resident Travel Survey...
Abstract: Long noncoding RNA (lncRNA) has been proven to be involved in many biological processes ovarian cancer (OC). However, the mechanism still remains unknown. In this study, we screened significantly downregulated NBAT-1, which play a significant role breast cancer, clear cell renal carcinoma, and neuroblastoma, but not OC, two independent datasets with relatively more samples (GSE18520 GSE38666) from Gene Expression Omnibus. We found that lncRNA NBAT-1 was obviously OC tissue compared...
Abstract Background Autophagy is associated with cancer development. Autophagy-related genes play significant roles in endometrial (EC), a major gynecological malignancy worldwide, but little was known about their value as prognostic markers. Here we evaluated the of signature based on autophagy-related for EC. Methods First, various were obtained via Human Database and expression profiles downloaded from The Cancer Genome Atlas. Second, key identified univariate, LASSO multivariate Cox...
Background: Tumor mutation burden (TMB) is considered as a novel biomarker of response to immunotherapy and correlated with survival outcomes in various malignancies.Here, TMB-related genes (TRGs) expression signatures were constructed investigate the association between TMB prognosis epithelial ovarian cancer (EOC), potential mechanism immunoregulation was also explored.Methods: Based on somatic data 436 EOC samples from The Cancer Genome Atlas database, we examined relationship level...
The introduction of PARP inhibitors (PARPis) and immune checkpoint (ICIs) has marked a significant shift in the treatment landscape for solid tumors. Emerging preclinical evidence initial clinical trials have indicated that synergistic application PARPis ICIs may enhance efficacy potentially improve long-term patient outcomes. Nonetheless, how to identify specific tumor types molecular subgroups most likely benefit from this combination remains an area ongoing research. This review...
Endometrial cancer (EC) is one kind of women cancers. Bioinformatic technology could screen out relative genes which made targeted therapy becoming conventionalized.GSE17025 were downloaded from GEO. The genomic data and clinical obtained TCGA. R software bioconductor packages used to identify the DEGs. Clusterprofiler was for functional analysis. STRING assess PPI information plug-in MCODE hub modules in Cytoscape. selected coped with CMap find EC-related drugs that might have potential...
Gravity-driven membrane (GDM) filtration technology has been extensively in the employed drinking water treatment, however, effect mode (i.e., dead-end vs. cross-flow mode) on its long-term performance not systematically investigated. In this study, pilot-scale GDM systems were operated using two submerged (SGDM) and (CGDM) at gravity-driven pressures 120 mbar 200 mbar, respectively. The results showed that flux stabilization was observed both SGDM CGDM during filtration, importantly...
Ovarian granulosa cell tumors (OGCTs) feature low incidence, indolent growth and late recurrence. Treatment for recurrent OGCTs is challenging.
Parasitic flatworms of the genus Schistosoma infect a wide range definitive hosts, which are categorized as permissive or non-permissive based on their capacity to support parasite development. Unlike hosts such mice, japonicum undergoes pronounced developmental arrest in like rats; however, molecular mechanisms underlying this phenomenon remain largely unclear. In study, we conducted comprehensive morphological and transcriptomic comparison S. derived from mouse rat at multiple time points...
5565 Background: IBI354 is an antibody-drug conjugate consisting of trastuzumab (anti-HER2 antibody) conjugated to a topoisomerase I inhibitor. It has showed manageable safety and encouraging efficacy in patients (pts) with advanced gynecologic cancers (including ovarian [OC], Shu et al, abstract No. 720MO at 2024 ESMO annual meeting). Here, we present the updated OC. Methods: Eligible OC pts HER2 alteration (IHC 1+, 2+, 3+ and/or ISH+ NGS confirmed mutation or amplification) who failed were...