A5071350580- Neuropeptides and Animal Physiology
- Neurological disorders and treatments
- Gastrointestinal motility and disorders
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Marine Biology and Ecology Research
- Regulation of Appetite and Obesity
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Vestibular and auditory disorders
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Tuberculosis Research and Epidemiology
- Neuroscience and Neural Engineering
- Biochemical Analysis and Sensing Techniques
- Drug-Induced Hepatotoxicity and Protection
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Traumatic Brain Injury and Neurovascular Disturbances
- Plant-based Medicinal Research
- Drug Transport and Resistance Mechanisms
- Coral and Marine Ecosystems Studies
- Heat shock proteins research
- Circadian rhythm and melatonin
Laboratoire de Neurosciences Cognitives
2014-2023
Centre National de la Recherche Scientifique
2010-2016
Aix-Marseille Université
2010-2016
Délégation Provence et Corse
2016
École Nationale Vétérinaire de Toulouse
2008
Université des Antilles
2000-2003
Over the last decade, striatal cholinergic interneurons (ChIs) have reemerged as key actors in pathophysiology of basal-ganglia-related movement disorders. However, mechanisms involved are still unclear. In this study, we address role ChI activity expression parkinsonian-like motor deficits a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) lesion model using optogenetic and pharmacological approaches. Dorsal photoinhibition ChIs lesioned ChAT<sup>cre/cre</sup> mice expressing...
Perinatal brain injury including white matter damage (WMD) is highly related to sensory, motor or cognitive impairments in humans born prematurely. Our aim was examine the neuroanatomical, functional and behavioral changes adult rats that experienced prenatal ischemia (PI), thereby inducing WMD. PI induced by unilateral uterine artery ligation at E17 pregnant rats. We assessed performances gait, abilities topographical organization of maps, neuronal glial density primary somatosensory...
Parkinson's disease has traditionally been viewed as a motor disorder caused by the loss of dopamine (DA) neurons. However, emotional and cognitive syndromes can precede onset deficits provide an opportunity for therapeutic intervention. Potassium channels have recently emerged potential new targets in treatment disease. The selective blockade small conductance calcium-activated K+ (SK channels) apamin is known to increase burst firing midbrain DA neurons therefore release. We thus...
This study presents the first comprehensive helminthological data on three sympatric riparian mustelids (the European mink Mustela lutreola, polecat M. putorius and American vison) in south-western France. One hundred twenty-four specimens (45 37 42 from eight French departments were analysed. Globally, 15 helminth species detected: Troglotrema acutum, Pseudamphistomum truncatum, Euryhelmis squamula, Euparyphium melis Ascocotyle sp. (Trematoda), Taenia tenuicollis (Cestoda), Eucoleus...
Unilateral vestibular deafferentation results in strong microglial and astroglial activation the nuclei (VN) that could be due to an inflammatory response. This study was aimed at determining if markers of inflammation are upregulated VN after chemical unilateral labyrinthectomy (UL) rat, response, any, induces expression neuroprotective factors promote plasticity mechanisms involved compensation process. The expressions or mechanical UL were also compared verify response not toxicity sodium...
ABSTRACT Target DNA from the uncultivable Codakia orbicularis endosymbiont was PCR amplified sea-grass sediment. To confirm that such amplifications originated intact bacterial cells rather than free DNA, whole-cell hybridization (fluorescence in situ technique) with specific probe Symco2 performed along experimental infection of aposymbiotic juveniles placed contact same Taken together, data demonstrate sulfide-oxidizing gill is present environment as a free-living form.
Immunohistochemical methods were applied in the present study to investigate expression of stress proteins such as metallothioneins (MT), which are metal-binding proteins, and heat shock (Hsp70), well an antioxidant enzyme (superoxide dismutase, SOD), freshwater crustacean copepod Hemidiaptomus roubaui (Richard, 1888) exposed cadmium or stress. The results show a tissue-specific distribution MT-like protein after exposure brain nerve cord. Cadmium did not provoke inducible Hsp70 SOD...
Single channel patch-clamp techniques were used to demonstrate the presence of outwardly rectifying chloride channels in basolateral membrane crypt cells from mouse distal colon. These rarely observed cell-attached mode and, inside-out configuration, only became active after a delay and depolarizing voltage steps. conductance was 23.4 pS between -100 -40 mV increased 90.2 40 100 mV. The permeability sequence for anions was: I(-) > SCN(-) Br(-) Cl(-) NO(3)(-) F(-)>> SO(4)(2-) approximately...
Copepods are the main metazoan component of zooplankton, in terms both number species and biomass. Thus, they have a key role pelagic food webs; but curiously, nothing is known neuroendocrine substances involved their physiological processes. In higher crustaceans, especially Decapoda, such molecules different processes (motility, feeding, reproduction, day-night migrations so on) has been well explored; so, we mapped expression sites some these to provide better understanding copepod...
Excessive inhibition of the external globus pallidus (GPe) by striatal GABAergic neurons is considered a central mechanism contributing to motor symptoms Parkinson's disease (PD). While electrophysiological findings support this view, behavioral studies assessing beneficial effects global GPe activations are scarce and reported results controversial. We used an optogenetic approach standard unilateral 6-hydroxydopamine nigrostriatal dopamine (DA) lesion model PD explore photostimulation on...
Ztaou, Samiraa; Liberge, Martinea; Nicolas, Mauriceb; Camon, Jérémya; Jaouen, Florenceb; Lydia Kerkerian-Le, Goffb; Amalric, Mariannea; Beurrier, Corinneb Author Information
Ztaou, Samiraa; Liberge, Martinea; Nicolas, Mauriceb; Camon, Jérémya; Jaouen, Florenceb; Kerkerian-Le Goff, Lydiab; Amalric, Mariannea; Beurrier, Corinneb Author Information