Lei Huang

ORCID: 0000-0002-3911-0915
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About
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Research Areas
  • Cardiomyopathy and Myosin Studies
  • Aquaculture disease management and microbiota
  • Mechanical Circulatory Support Devices
  • Cardiovascular Function and Risk Factors
  • Photonic and Optical Devices
  • Mechanical and Optical Resonators
  • Cardiac Arrest and Resuscitation
  • Atherosclerosis and Cardiovascular Diseases
  • Aquaculture Nutrition and Growth
  • Cardiovascular Disease and Adiposity
  • Coastal wetland ecosystem dynamics
  • Cardiac Imaging and Diagnostics
  • Cardiac Structural Anomalies and Repair
  • Microbial Community Ecology and Physiology
  • Cancer-related molecular mechanisms research
  • Antibiotic Resistance in Bacteria
  • Acute Myocardial Infarction Research
  • Respiratory Support and Mechanisms
  • Metabolomics and Mass Spectrometry Studies
  • Adipose Tissue and Metabolism
  • Metal and Thin Film Mechanics
  • Essential Oils and Antimicrobial Activity
  • MicroRNA in disease regulation
  • Bacterial biofilms and quorum sensing
  • Listeria monocytogenes in Food Safety

Tianjin Third Central Hospital
2016-2025

Tianjin Medical University
2016-2025

Nankai University
2023-2025

Tianjin International Joint Academy of Biomedicine
2022-2025

Tianjin University
2025

Tianjin Central Hospital of Gynecology Obstetrics
2025

Zhejiang Institute of Freshwater Fisheries
2023-2025

Ministry of Agriculture and Rural Affairs
2025

China Three Gorges Corporation (China)
2025

Institute of New Materials
2025

Aerobic glycolysis or the Warburg Effect (WE) is characterized by increased metabolism of glucose to lactate. It remains unknown what quantitative changes activity are necessary and sufficient for this phenotype. We developed a computational model an integrated analysis using metabolic control (MCA), metabolomics data, statistical simulations. identified confirmed novel mode regulation specific aerobic where flux through GAPDH, enzyme separating lower upper glycolysis, rate-limiting step in...

10.7554/elife.03342 article EN cc-by eLife 2014-07-09

Objective: Epinephrine has been the primary drug for cardiopulmonary resuscitation (CPR) more than a century. The therapeutic rationale was to restore threshold levels of myocardial and cerebral blood flows by its alpha1 (α1) alpha2 (α2)-adrenergic agonist vasopressor actions. On basis coincidental observations on changes in microvascular flow cortex, we hypothesized that epinephrine selectively decreases flow. Design: Randomized prospective animal study. Setting: University-affiliated...

10.1097/ccm.0b013e31819cedc9 article EN Critical Care Medicine 2009-04-01

Klebsiella pneumoniae (KP) is a pathogen commonly causing nosocomial infection. Carbapenem-resistant KP (CRKP) more resistant to multiple antimicrobial drugs than carbapenem-susceptible (CSKP) isolates. The aim of the present study was identify risk factors for CRKP infection and predictors mortality among KP-infected adult patients.Patients with CSKP were categorized as case group control group, respectively, we conducted 1:1 ratio case-control on these groups. isolates collected tested...

10.4103/0366-6999.221267 article EN cc-by-nc-nd Chinese Medical Journal 2018-01-04

Abstract Background Microbiome assembly in early life may have a long-term impact on host health. Larval nursery is crucial period that determines the success culture of Litopenaeus vannamei , most productive shrimp species world aquaculture industry. However, succession patterns and mechanisms larval bacterial community still lack characterization at fine temporal scale. Here, using high-frequency sampling strategy 16S rRNA gene amplicon sequencing, we investigated dynamics its relationship...

10.1186/s40168-020-00879-w article EN cc-by Microbiome 2020-07-03

This study comprehensively employs data analysis, simulation, and characterization techniques to investigate the causes of surface spalling defects in low‐nickel austenitic stainless steel. The results indicate that there are components mold fluxes at defect location. Correlation calculations smelting process demonstrate a significant association between fluctuation cooling water temperature difference occurrence defects. is attributed reduced heat transfer caused by using with higher...

10.1002/srin.202400957 article EN steel research international 2025-04-02

Sulforaphane (SFN) is reported to reduce the accumulation of lipids. However, underling mechanism remains unclear. In this study, potential SFN improve lipid metabolism investigated through altering mitochondrial function and biogenesis-related mechanisms.The abnormal model was established both in HHL-5 cells rats by feeding a high-fat diet (HFD) for 10 weeks. The current findings suggest that alleviates swelling mitochondria stimulates biogenesis. reduced expression NRF1 TFAM, were reversed...

10.1002/mnfr.201800795 article EN Molecular Nutrition & Food Research 2018-12-22

Increasing evidence has emerged supporting a tight link between gut bacterial community and shrimp health. However, the knowledge about variation of community, especially with different disease onset time, remains elusive. Here, healthy diseased shrimps were collected at 3 disease-outbreak times (day 70, 80 85) to investigate its underlying ecological process 16S rRNA gene amplicon sequencing. The was distinct from one temporally less stable, characterized by decreased alpha-diversity...

10.1186/s13568-018-0644-x article EN cc-by AMB Express 2018-07-18

Increasing the C/N ratio of input feed has been reported as a practical approach for improving water quality and enhancing shrimp growth through changing bacterial community rearing water. However, little is known about effects different ratios on intestinal microbiota metabolome shrimp. In present study, three levels (CN6, CN10 CN15) maintained by adding sucrose growth, Litopenaeus vannamei, bioflocs formation were investigated after 17 days feeding. The results indicated that higher (10...

10.3389/fmicb.2020.00652 article EN cc-by Frontiers in Microbiology 2020-04-15

Sucrose is an effective carbon source for creating more reliable and environmentally friendly conditions shrimp growth by regulating bacteria in biofloc-based culture systems. However, the influence of sucrose addition on interaction, co-occurrence networks, assembly mechanisms bacterial communities systems remains largely unknown. Here, we comprehensively investigated effects three habitats (water, bioflocs, gut). The community structures compositions these became similar groups with...

10.1038/s41522-022-00288-x article EN cc-by npj Biofilms and Microbiomes 2022-04-11

Shrimp cultured in a biofloc system (BFS) have lower disease incidence than those farmed water exchange (WES). Although number of studies reported that the gut bacterial community induced by BFS is highly associated with shrimp resistance, causal relationship remains unknown. Here, promotive roles pathogenic Vibrio infection resistance and its potential micro-ecological physiological mechanisms were investigated consortium transplantation synthetic (SynCom) construction.The more stable...

10.1186/s40168-023-01663-2 article EN cc-by Microbiome 2023-10-19

Supplementing exogenous carbon sources is a practical approach to improving shrimp health by manipulating the microbial communities of aquaculture systems. However, little known about microbiological processes and mechanisms these Here, effects glucose addition on growth performance bacterial rearing water gut were investigated address this knowledge gap. The results showed that significantly improved survival shrimp. Although α-diversity indices both bacterioplankton microbiota decreased...

10.1007/s42995-021-00124-9 article EN cc-by Marine Life Science & Technology 2022-01-01

This study aims to explore the impact of physician-nurse collaboration on nurse job satisfaction and turnover in a dental hospital. Physician-nurse is important for stability entire nursing team. Few studies have shown among nurses working Chinese hospitals. was prospective, cross-sectional investigated from tertiary hospital Beijing using convenience non-randomized sampling. A structured questionnaire used collect data, which included general information, Index Work Satisfaction,...

10.1111/ijn.12424 article EN International Journal of Nursing Practice 2016-03-08

The spectral shift response of optical whispering-gallery modes due to the adsorption and desorption water molecules into a SiO2 nano-coating is investigated. This coating applied silica microsphere optical-shift measurements are made at very low humidity level (<10%). micro-optical coupling system incorporated sealed vacuum chamber for controlled testing. experimental observation whispering-gallery-mode with refractive index consistent theoretical analysis using Mie theory. A significant...

10.1088/0957-0233/21/11/115206 article EN Measurement Science and Technology 2010-10-18

Foreign body (FB) ingestion is a common emergency as well major cause of accidental injury and represents severe public health problem in childhood, especially infants. Most cases FB reported children aged between 6 months 3 years depend primarily on the fact that young are more likely to explore objects using their mouth not able distinguish edible from nonedible ones, teeth physiologically lacking, they have poor swallowing coordination. Although, sometimes it can serious complications,...

10.1159/000450538 article EN cc-by-nc Case Reports in Gastroenterology 2016-11-25

Commercial microbial agents (e.g. probiotics, products, microorganism preparation et al.) have been widely applied for disease control in shrimp culture. However, the effect of these (MA) on health is unstable and underlying mechanism remains unclear. The MA can probably be achieved by influencing bacterial community culture system. To test this hypothesis, we used 16S rRNA gene amplicon sequencing to investigate dynamics both planktonic intestinal composition ponds with or without...

10.3389/fmicb.2018.02430 article EN cc-by Frontiers in Microbiology 2018-10-11

The objective of this study is to investigate the effect solidification microstructure CJ5L Recycled Stainless Steel in cast state on its thermoplasticity. Therefore, residual ferrite, structure, and high-temperature thermoplasticity both Non-Recycled steel ingots are examined. principal experimental techniques employed include SEM, OM, EPMA, EDS. It was observed that underwent a gradual transformation from dendritic structure with skeletal shape worm-like dendrite as thickness increased....

10.3390/ma18051156 article EN Materials 2025-03-05
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