A5007132405- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Diet and metabolism studies
- Sleep and related disorders
- Eating Disorders and Behaviors
- Birth, Development, and Health
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Body Contouring and Surgery
- Youth Substance Use and School Attendance
- RNA Research and Splicing
- Psychological Treatments and Assessments
- RNA modifications and cancer
- Biochemical Analysis and Sensing Techniques
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Neurotransmitter Receptor Influence on Behavior
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Bariatric Surgery and Outcomes
GGZ Drenthe
2020-2025
Johns Hopkins University
2012-2021
Johns Hopkins Medicine
2012-2021
Uppsala University
2018-2019
Indiana University School of Medicine
2013
Centre for Movement Disorders
2013
University of Baltimore
2013
University of Groningen
2009-2012
Florida State University
2006
There is ample evidence that exposure to stress during gestation increases the risk of offspring develop mood disorders. Brain-derived neurotrophic factor (Bdnf) plays a critical role neuronal development and therefore prime candidate modulate signaling in adult rat dams were stressed gestation. In current study, we tested hypothesis alterations Bdnf expression prenatally (PNS) are mediated by changes DNA methylation exons IV VI gene. We observed decreased amygdala hippocampus rats both at...
Here, we explore the involvement of FKBP51 in glucocorticoid-induced insulin resistance (IR) human subcutaneous adipose tissue (SAT), including its potential role type 2 diabetes (T2D). Moreover, assess metabolic effects reducing activity using specific inhibitor SAFit1.Human SAT was obtained by needle biopsies lower abdominal region. FKBP5 gene expression assessed fresh explants from a cohort 20 T2D subjects group-wise matched gender, age and BMI to non-diabetic subjects. In addition,...
We assessed glucose uptake in different tissues type 2 diabetes (T2D), prediabetes, and control subjects to elucidate its impact the development of whole-body insulin resistance T2D. Thirteen T2D, 12 10 subjects, matched for age BMI, underwent OGTT abdominal subcutaneous adipose tissue (SAT) biopsies. Integrated 18F-FDG PET MRI were performed during a hyperinsulinemic euglycemic clamp asses rate (MRglu) several tissues. MRglu skeletal muscle, SAT, visceral (VAT), liver was significantly...
This study aimed to determine how the rat placenta and fetus respond maternal high-fat (HF) diet during gestation identify possible mechanisms.Pregnant Sprague-Dawley rats were fed with standard chow (13.5% fat) or HF (60% gestation. Placentas collected on day 21.HF dams had greater fat mass, higher plasma leptin, lower adiponectin, impaired glucose tolerance pregnancy. The placental labyrinth thickness was reduced in both male female fetuses of dams. In placentas, transporter 3 gene...
The adverse effects of stress on brain and behavior have long been known well-studied, with abundant evidence linking to, among other things, mood anxiety disorders. Likewise, many investigated potential treatments for stress-related phenotypes demonstrated good response to standard antidepressant medications like selective serotonin reuptake inhibitors (SSRIs), as well environmental manipulations exercise or enrichment. However, the extent which various act overlapping pathways in is less...
Chronic exposure to glucocorticoids (GCs) can lead psychiatric complications through epigenetic mechanisms such as DNA methylation (DNAm). We sought determine whether changes in a peripheral tissue serve surrogate for those relatively inaccessible the brain. extracted from hippocampus and blood of mice treated with GCs or vehicle solution was assayed using genome-wide DNAm platform (Methyl-Seq) identify differentially methylated regions (DMRs) induced by GC treatment. observed that ∼70% DMRs...
Background Shift work is generally associated with working and sleeping out of phase the endogenous, circadian sleep–wake cycle. This exerts detrimental effects on sleep health. The present study aimed at evaluating presence short long as well disorders within a broad range shift schedules elucidating role sociodemographic factors therein. Methods A large dataset containing information was collected through advertisement in Belgium newspaper (De Standaard). Adult, individuals were selected...
Maternal high-fat (HF) diet has long-term consequences on the metabolic phenotype of offspring. Here, we determined effects postweaning exercise in offspring rat dams fed HF during gestation and lactation. Pregnant Sprague-Dawley rats were maintained chow or throughout All pups weaned onto postnatal day (PND) 21. At 4 wk age, male given free access to running wheels (RW) remained sedentary (SED) for 3 wk, after which all sedentary, resulting four groups: CHOW-SED, CHOW-RW, HF-SED, HF-RW....
Roux-en-Y gastric bypass (RYGB) surgery effectively prevents or treats type 2 diabetes (T2D). Adipose tissue (AT) mechanisms may be of importance. To assess the relationship between early changes in whole-body and AT metabolism surgically treated patients with T2D. A randomized single-center study. Nineteen T2D body mass index 30 to 45 kg/m2. Thirteen were assessed at baseline 4 24 weeks after RYGB (preceded by a 4-week low-calorie diet) compared 6 control continuing standard medical...
Background: Insomnia is common in forensic psychiatric patients. Not only does insomnia severely impair general mental health, but it has specifically been associated with poor emotion regulation and self-control, potentially leading to problems impulsivity, hostility, even aggression. Cognitive behavioral therapy for (CBT-I) could therefore be beneficial this patient group. Methods: We conducted a 14-week randomized controlled trial of the effects cognitive on sleep, psychopathology,...
ABSTRACT Relapse rates are high amongst cases of anorexia nervosa (AN) suggesting that some alterations induced by AN may remain after weight restoration. Objective To study the consequences without confounds environmental variability, a rodent model activity‐based (ABA) can be employed. We hypothesized exposure to ABA during adolescence have long‐term in taste function, cognition, and anxiety‐like behavior Methods test this hypothesis, we exposed adolescent female rats (1.5 h food access,...
Both prenatal stress (PNS) exposure and a passive stress-coping style have been identified as risk factors for insulin resistance in rats. In the current study, we test hypothesis that PNS may interact predicting susceptibility metabolic disease. To this hypothesis, adult male control offspring were behaviorally characterized using defensive burying to either or proactive style. adulthood, all rats fed standard chow high-fat diet 3 weeks. After weeks of exposure, glucose levels assessed...
Summary Sleep problems are very common in individuals with a mental disorder. Given the abundant evidence indicating negative impact of disturbed sleep on health outcome, insight into prevalence all types disorders specific and neurodevelopmental conditions is practical importance. Therefore, we estimated six Holland Disorders Questionnaire an overall sample ( n = 1082) separately for different conditions. Furthermore, associations between disorders, psychopathology well‐being were studied....