A5010324924- Birth, Development, and Health
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Autism Spectrum Disorder Research
- Gastrointestinal motility and disorders
- Regulation of Appetite and Obesity
- Advanced Biosensing Techniques and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Molecular Biology Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Asthma and respiratory diseases
- Amino Acid Enzymes and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Biochemical effects in animals
- Spinal Dysraphism and Malformations
- Clinical Reasoning and Diagnostic Skills
- Restless Legs Syndrome Research
- Antioxidants, Aging, Portulaca oleracea
- Cancer, Stress, Anesthesia, and Immune Response
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Bone health and osteoporosis research
- Immune Cell Function and Interaction
Oregon Health & Science University
2022-2024
Johns Hopkins University
2018-2022
Johns Hopkins Medicine
2018-2022
Medical education is currently undergoing a paradigm shift from process-based to competency-based education, focused on measuring the desired competence of physician. In an attempt improve assessment framework used for medical concept entrustable professional activities (EPAs) has gained traction. EPAs are defined as that can be entrusted individual in clinical context. The Association American Colleges (AAMC) set 13 such define core what all students should able do day 1 residency,...
ABSTRACT Background and Purpose An association recently emerged between magnetic resonance imaging (MRI)-visible perivascular spaces (MV-PVS) with intracerebral solute clearance neuroinflammation, in adults. However, it is unknown how MV-PVS change throughout adolescence what factors influence volume morphology. This study assesses the temporal evolution of adolescents young adults, secondarily evaluates relationship MV-PVS, age, sex, body mass index (BMI). Materials Methods analysis...
Abstract Maternal stressors during the prenatal and perinatal periods are associated with increased susceptibility for severity of chronic disease phenotypes in adult offspring. In this study, we used a rat model maternal high-fat diet (HFD) exposure pregnancy lactation to investigate impact on skeletal homeostasis distal femur, young male female offspring (up 3 weeks age) from dams fed HFD exhibited marked increases trabecular bone volume relative chow diet, but was followed by sustained...
As patients with anorexia nervosa tend to "like" palatable tastants less than controls, we set out model this preclinically by using the taste reactivity test (TRT) assess hedonic state in rats following weight restoration from a bout of activity-based (ABA).Female (n = 31) were surgically implanted an intraoral catheter, which allowed experimenters baseline TRT six tastants. Following TRT, animals either exposed condition (ABA; 1.5HR chow/ad lib wheel until 25% loss), kept sedentary (SED;...
OBJECTIVES/GOALS: Weaimed to compare subjective and objective sleep in individuals with chronic post-concussive symptoms. We hypothesized an association between self-reported quality parameters, which is different for concussed control cohorts. METHODS/STUDY POPULATION: 28 symptoms 13 age-matched controls (no concussion history) completed the ISI, PSQI, PROMIS Depression, Anxiety, Stress Cognitive questionnaires at enrollment. Objective parameters were obtained a minimum of 7 days up 30...
The ANK3 locus has been repeatedly found to confer an increased risk for bipolar disorder. codes Ankyrin-G (Ank-G), a scaffold protein concentrated at axon initial segments, nodes of Ranvier, and dendritic spines, where it organizes voltage-gated sodium potassium channels cytoskeletal proteins. Mice with homozygous conditional knockout Ank-G in the adult forebrain display hyperactivity reduced anxiety-like behaviors, responsive mood stabilizers. Their behavior switches depression-like...
Abstract A key component to overcoming the reproducibility crisis in biomedical research is development of readily available, rigorously validated and renewable protein affinity reagents. As part NIH Protein Capture Reagents Program (PCRP), we have generated a collection 1406 highly validated, immunoprecipitation (IP) and/or immunoblotting (IB) grade, mouse monoclonal antibodies (mAbs) 736 human transcription factors. We used HuProt™ microarrays identify mAbs that recognize their cognate...