A5086427888- Gut microbiota and health
- Mast cells and histamine
- Inflammatory Bowel Disease
- Allergic Rhinitis and Sensitization
- Probiotics and Fermented Foods
- Food Allergy and Anaphylaxis Research
- Clostridium difficile and Clostridium perfringens research
- Protein Hydrolysis and Bioactive Peptides
IgE is central to the development of allergic diseases, and its neutralization alleviates symptoms. However, most these antibodies are based on IgG1, which associated with an increased risk fragment crystallizable-mediated side effects. Moreover, omalizumab, anti-IgE antibody approved for therapeutic use, has limited benefits patients high levels. Here, we assess a fusion protein extracellular domain affinity receptor, FcεRIα, linked IgD/IgG4 hybrid Fc term IgETRAP, reduce IgG1 Fc-mediated...
Glucagon-like peptide-1 (GLP-1) is a hormone secreted from enteroendocrine cells that can promote weight loss and blood glucose improvement. We screened probiotic strains effectively stimulate GLP-1 secretion human then investigated the efficacy of this strain in high-fat diet (HFD)-induced mouse model obesity. Lactiplantibacillus plantarum GB104 greatly induced by increasing expression proglucagon gene (GCG), but not proprotein convertase subtilisin/kexin type 1 (PCSK1) cell line NCI-H716....
Given the recognized involvement of gut microbiome in development obesity, considerable efforts are being made to discover probiotics capable preventing and managing obesity. In this study, we report discovery Lactiplantibacillus plantarum GBCC_F0227, isolated from fermented food, which exhibited superior triglyceride catabolism efficacy compared L. WCSF1. Molecular analysis showed elevated expression levels α/β hydrolases with lipase activity (abH04, abH08_1, abH08_2, abH11_1, abH11_2)...
Fecal samples were collected from 640 individuals in Korea, including 523 patients with IBD (223 Crohn's disease [CD] and 300 ulcerative colitis [UC]) 117 healthy controls. The subjected to cross-sectional gut metagenomic analysis using 16 S rRNA sequencing bioinformatics analysis. Patients IBD, particularly those CD, exhibited significantly lower alpha diversities than the subjects. Differential abundance revealed dysbiotic signatures, characterized by an expansion of genus...