A5101741558- Liver Disease Diagnosis and Treatment
- Statistical Methods and Inference
- Statistical Methods in Clinical Trials
- Fuzzy Systems and Optimization
- Mesenchymal stem cell research
- Gut microbiota and health
- Liver Disease and Transplantation
- Gastroesophageal reflux and treatments
- Health Systems, Economic Evaluations, Quality of Life
- HER2/EGFR in Cancer Research
- Recommender Systems and Techniques
- Data Management and Algorithms
- Organ Transplantation Techniques and Outcomes
- Genetic and phenotypic traits in livestock
- Antimicrobial Peptides and Activities
- Tissue Engineering and Regenerative Medicine
- Probiotics and Fermented Foods
- Bayesian Modeling and Causal Inference
- Meta-analysis and systematic reviews
- Microbial Community Ecology and Physiology
- Advanced Statistical Methods and Models
- Human Mobility and Location-Based Analysis
- Genomics and Phylogenetic Studies
- Optimal Experimental Design Methods
- Nutrition, Health and Food Behavior
Pyeongtaek University
2004-2023
Kangwon National University
2022
Seoul National University
2000-2020
Busan National University of Education
2020
Yeungnam University
2015-2020
Seoul St. Mary's Hospital
2017
Catholic University of Korea
2017
Pukyong National University
2015
National Heart Lung and Blood Institute
2010-2013
National Institutes of Health
2009-2013
Previous studies using autologous bone marrow mononuclear cells (BMCs) in patients with ischemic cardiomyopathy have demonstrated safety and suggested efficacy.To determine if administration of BMCs through transendocardial injections improves myocardial perfusion, reduces left ventricular end-systolic volume (LVESV), or enhances maximal oxygen consumption coronary artery disease LV dysfunction, limiting heart failure angina.A phase 2 randomized double-blind, placebo-controlled trial...
While the delivery of cell therapy after ST-segment elevation myocardial infarction (STEMI) has been evaluated in previous clinical trials, influence timing on effect left ventricular function not analyzed.To determine intracoronary autologous bone marrow mononuclear (BMC) STEMI recovery global and regional whether BMC (3 days vs 7 reperfusion) influences this effect.A randomized, 2 × factorial, double-blind, placebo-controlled trial, Timing In Myocardial Evaluation (TIME) enrolled 120...
BackgroundFrequent painful vaso-occlusive crises (VOCs) were associated with mortality in the Cooperative Study of Sickle Cell Disease (CSSCD) over twenty years ago. Modern therapies for sickle cell anemia (SCA) like hydroxyurea are believed to have improved overall patient survival. The current study sought determine relevance association between more frequent VOCs and death its relative impact upon compared other known risk factors a contemporary adult SCA cohort. MethodsTwo hundred sixty...
Rationale: Distinct sets of corticosteroid-unresponsive genes modulate disease severity in asthma.Objectives: To identify that provide new insights into pathogenesis and asthma therapeutics.Methods: Experimental murine was induced by nasal administration house dust mite for 5 days per week. Dexamethasone apolipoprotein E (apo E) mimetic peptides were administered via osmotic minipumps.Measurements Main Results: Genome-wide expression profiling the lung transcriptome a mite–induced model...
ABSTRACT Endophytes live inside plant tissues without causing any harm and may even benefit plants. Here, we provide the high-quality genome sequence of Burkholderia sp. strain KJ006, an endophytic bacterium rice with antifungal activity. The 6.6-Mb genome, consisting three chromosomes a single plasmid, contains genes related to growth promotion or degradation aromatic compounds.
New therapies are needed to improve the prognosis of patients with metastatic melanoma. This study evaluates safety and efficacy weekly paclitaxel in Patients received at 80 mg/m over 1 h, for 3 weeks, followed by a 1-week rest period. Disease status was assessed every other cycle. Treatment continued until experienced either disease progression or unacceptable toxicity. Twenty-seven were enrolled this phase II clinical trial. Of these patients, two subsequently determined be ineligible. All...
Given the recognized involvement of gut microbiome in development obesity, considerable efforts are being made to discover probiotics capable preventing and managing obesity. In this study, we report discovery Lactiplantibacillus plantarum GBCC_F0227, isolated from fermented food, which exhibited superior triglyceride catabolism efficacy compared L. WCSF1. Molecular analysis showed elevated expression levels α/β hydrolases with lipase activity (abH04, abH08_1, abH08_2, abH11_1, abH11_2)...
A highly stereoselective asymmetric total synthesis of (−)-jimenezin (1), a potent anticancer acetogenin, was efficiently completed with the key feature being sequential intramolecular amide enolate alkylation (IAEA). Our investigation to probe origin complete stereoselectivity in second IAEA step form conformationally flexible tetrahydrofuran perfect stereocontrol identified presence oxygen atom adjacent tetrahydropyran ring be crucial.
Background: Serum asialo α1-acid gycoprotein (AsAGP) is a novel biomarker specific to liver fibrosis. Aim: To evaluate the diagnostic efficacy of serum AsAGP levels in classifying severity fibrosis and differentiating cirrhosis (LC) patients with chronic hepatitis B (CHB) from healthy controls. Methods: Overall, 206 subjects were prospectively enrolled. LC was diagnosed based on stiffness (>11 kPa) measured using transient elastography. an antibody-lectin sandwich immunoassay. We...
Pulmonary dysfunctions including the hepatopulmonary syndrome and portosystemic shunt are important complications of hepatic cirrhosis. To investigate severity nature abnormal gas diffusing capacity its correlation to in patients with chronic liver disease.Forty-four disease (15 active hepatitis (CAH), 16 Child-Pugh class A, 13 B) without other diseases history were enrolled study. Evaluation function tests, arterial blood gases analysis, ultrasonography, pulmonary test lung carbon monoxide...
Various predictive modeling approaches based on the customers' information may be used for selecting proper targets a promoted product to entice customers into purchasers. However, there is fundamental problem, incomplete data which can yie
Objective The General-Food Craving Questionnaire-Trait (G-FCQ-T) is a validated, assessment scale for food craving. aim of this study was to measure its reliability and validity Korean children. Methods A total 172 children (94 boys 78 girls) were selected fill out set questionnaires, including the G-FCQ-T, Children's version Dutch Eating Behavior Questionnaire (DEBQ-C), Three-Factor (TFEQ) in language. Results internal consistency (Cronbach's alpha=0.933) test-retest (r=0.653) satisfactory....
This study investigated the therapeutic effects of combined local irradiation and anti-HER2/neu antibody in a mixed tumor mouse model comprised nonmetastatic neu-positive metastatic neu-negative tumor. While alone could control primary dose-dependent manner, it did not improve survival. Combined treatment anti-neu tumor-bearing BALB/c mice significantly improved survival (P < 0.5), even though growth was similar to that irradiated-alone group. The reduced masses lung increased immune cell...
Migraine is a relatively common disease that has significant effect on the daily activities of affected individuals. The purpose this study was to explore effects herbal medicine (Jodeungsan, JDS) migraine.
Objectives The balance of confounding factors between treatment groups is supported by intention-to-treat (ITT) principle and this can reduce bias effects. Therefore clear definition analysis set blind review are essential prerequisites to perform statistical analysis. In paper, we discuss the check carefully data during a finalize in clinical trials. Methods concept ITT has been often mixed misused. Based on principle, proper sets required show efficacy must be determined for management...