A5032123971- Parkinson's Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Advanced Glycation End Products research
- Redox biology and oxidative stress
- Genomics, phytochemicals, and oxidative stress
- Alzheimer's disease research and treatments
Bioscience Research
2016
The University of Texas at El Paso
2014-2016
Nitrosative stress mediated S-nitrosylation (SNO) of protein disulfide isomerase (PDI), a housekeeping oxidoreductase, has been implicated in the pathogenesis sporadic Parkinson's (PD) and Alzheimer's (AD) diseases. Previous cell line studies have indicated that SNO-PDI formation provokes synphilin-1 aggregation, minor Parkinsonian biomarker protein. Yet no work exists investigating whether induces α-synuclein major Lewy body constituent associated with pathogenesis. Here, we report is...
Amyloid beta (Aβ) aggregation is generally associated with Alzheimer's onset. Here, we demonstrate that incubation of dopaminergic SH-SY5Y cells an Aβ peptide fragment (an 11-mer composed residues 25–35; (25–35)) results in elevated intracellular nitrosative stress and induces chemical mutation protein disulfide isomerase (PDI), endoplasmic reticulum-resident oxidoreductase chaperone. Furthermore, (25–35) provokes both the minor major biomarkers Parkinson's disease, namely, synphilin-1...