A5085074627- Catalytic Alkyne Reactions
- Ferroptosis and cancer prognosis
- Catalytic C–H Functionalization Methods
- Ubiquitin and proteasome pathways
- Molecular Junctions and Nanostructures
- Protein Degradation and Inhibitors
- Synthesis and Biological Evaluation
- Trace Elements in Health
- Catalytic Cross-Coupling Reactions
- Histone Deacetylase Inhibitors Research
- Chemical Synthesis and Analysis
- Drug Transport and Resistance Mechanisms
- Force Microscopy Techniques and Applications
- Synthesis and biological activity
- Cancer, Lipids, and Metabolism
- Research on Leishmaniasis Studies
- X-ray Diffraction in Crystallography
- Cell death mechanisms and regulation
- Trypanosoma species research and implications
- Synthetic Organic Chemistry Methods
- Genomics, phytochemicals, and oxidative stress
- Oxidative Organic Chemistry Reactions
- Supramolecular Self-Assembly in Materials
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
University of Massachusetts Amherst
2018-2025
The University of Texas at El Paso
2014-2019
Columbia University
2009-2016
McGill University
2005-2014
Howard Hughes Medical Institute
2011
Brookhaven National Laboratory
2010
Nanjing University
2009
South China University of Technology
2008-2009
Nanjing University of Aeronautics and Astronautics
2009
Université de Sherbrooke
2003
Exchange of extracellular cystine for intracellular glutamate by the antiporter system x c − is implicated in numerous pathologies. Pharmacological agents that inhibit activity with high potency have long been sought, but remained elusive. In this study, we report small molecule erastin a potent, selective inhibitor . RNA sequencing revealed inhibition cystine–glutamate exchange leads to activation an ER stress response and upregulation CHAC1 , providing pharmacodynamic marker inhibition. We...
Significance Cell death by regulated necrosis causes tremendous tissue damage in a wide variety of diseases, including myocardial infarction, stroke, sepsis, and ischemia–reperfusion injury upon solid organ transplantation. Here, we demonstrate that an iron-dependent form necrosis, referred to as ferroptosis, mediates synchronized functional units diverse organs ischemia other stimuli, thereby triggering detrimental immune response. We developed novel third-generation inhibitor ferroptosis...
Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited death in cellular models Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. developed mechanistic model to explain the activity Fer-1, which guided development ferrostatins with improved properties. These studies...
Copper, an essential element for various biological processes, demands precise regulation to avert detrimental health effects and potential cell toxicity. This paper explores the mechanisms of copper-induced death, known as cuproptosis, its disease implications, including cancer therapy. Copper ionophores, such elesclomol disulfiram, increase intracellular copper levels. elevation triggers oxidative stress subsequent offering implications in Additionally, ionophores disrupt mitochondrial...
Understanding electron transport across π−π-stacked systems will help to answer fundamental questions about biochemical redox processes and benefit the design of new materials molecular devices. Herein we employed STM break-junction technique measure single-molecule conductance multiple aromatic rings. We studied through up four stacked benzene rings held together in an eclipsed fashion via a paracyclophane scaffold. found that strained hydrocarbons herein couple directly gold electrodes...
Cell death is a complex process that plays vital role in development, homeostasis, and disease. Our understanding of ability to control cell impeded by an incomplete characterization the full range processes occur mammalian systems, especially response exogenous perturbations. We present here general approach address this problem, which we call modulatory profiling. Modulatory profiles are composed changes potency efficacy lethal compounds produced second death-modulating agent human lines....
E3 ubiquitin ligases are of interest as drug targets for their ability to regulate protein stability and function. The oncogene Mdm2 is an attractive ligase target, it the key negative regulator tumor suppressor p53, which controls transcription genes involved in cell fate. Overexpression facilitates tumorigenesis by inactivating through p53-independent oncogenic effects. We developed a high-throughput cellular auto-ubiquitination assay, we used discover class small-molecule activity...
We analyzed more than 1 million small molecules with the goal of finding simple synthetic compounds that potently inhibit cancer cell growth. identified three such unknown mechanisms action. Subsequent studies revealed all these target microtubules. These scaffolds can serve as templates for developing new microtubule-targeted agents, overcoming limits existing microtubule-inhibiting drugs derived from complex natural products.
Although preventable by vaccination, Measles still causes thousands of deaths among young children worldwide. The discovery new antivirals is a good approach to control outbreaks that cause such death. In this study, we tested the antiviral activity against virus (MeV) Polyphenol-rich extracts (PPs) coming from five seaweeds collected and cultivated in Mexico. An MTT assay was performed determine cytotoxicity effect, measured syncytia reduction confirmed qPCR. PPs Ecklonia arborea (formerly...
The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators in human body. Its central function involves reduction complex hydroperoxides into their respective alcohols often using reduced Glutathione (GSH) as a reducing agent. GPX4 has become hotspot therapeutic target biomedical research following its characterization chief regulator ferroptosis, and subsequent recognition specific pharmacological for treatment an extensive variety diseases including cancers...
The value of gold ‘n’ rings: An isoflavanone moiety is the key structural feature many complex natural products. It now shown that such structures can be generated efficiently and atom economically by annulation simple o-hydroxybenzaldehydes with alkynes in presence a gold(I) catalyst (see scheme).
Dissolved in nematic liquid crystals, rigid disk-shaped macrolactams may form large hexagonal hollow tubes. Computer modeling (see picture, O red, N blue, C gray, H white), Raman and infrared microspectroscopy reveal a hierarchical self-similar-structured self-assembly of the cyclic peptide liquid-crystal medium.
Alternative solvents such as supercritical carbon dioxide, water, and ionic liquids are receiving an increase of interest better replacements for conventional in chemical reactions. They have been called sustainable green because they highly promising reaction mediums organic synthesis. This review presents overview some selected reactions that developed these with a particular emphasis on metal-catalyzed