A5075458598- Metal complexes synthesis and properties
- Nanoparticle-Based Drug Delivery
- X-ray Diffraction in Crystallography
- Lanthanide and Transition Metal Complexes
- Organometallic Complex Synthesis and Catalysis
- Dendrimers and Hyperbranched Polymers
- Crystallization and Solubility Studies
- RNA and protein synthesis mechanisms
- Coenzyme Q10 studies and effects
- Electron Spin Resonance Studies
- Piperaceae Chemical and Biological Studies
- Chemical Synthesis and Analysis
- Plant-based Medicinal Research
- Plant biochemistry and biosynthesis
- Fungal Biology and Applications
- Silymarin and Mushroom Poisoning
- Synthesis of Tetrazole Derivatives
- Genomics, phytochemicals, and oxidative stress
- Inorganic and Organometallic Chemistry
- Quinazolinone synthesis and applications
- Phytochemistry and biological activity of medicinal plants
- Biological Activity of Diterpenoids and Biflavonoids
- Radioactive element chemistry and processing
- Chromatography in Natural Products
- Nanoparticles: synthesis and applications
Leibniz Institute of Plant Biochemistry
2019-2025
Royal Stoke University Hospital
2010
Ruthenium(II)–arene complexes have gained significant research interest due to their possible application in cancer therapy. In this contribution two new are described, namely [{RuCl(η6-p-cymene)}2(μ-Cl)(μ-1-N,N′-naphthyl)]X (X = Cl, 1; PF6, 2), which were fully characterized by IR, NMR, and elemental microanalysis. Furthermore, the structure of 2 solid state was determined a single crystal X-ray crystallographic study, confirming composition crystals as 2·2MeOH. The Hirshfeld surface...
Balanites aegyptiaca (L.) Delile (Zygophyllaceae), also known as the desert date, is an edible fruit-producing tree popular for its nutritional and several health benefits.
Organotin(IV) carboxylates are a class of compounds explored as alternatives to platinum-containing chemotherapeutics due propitious in vitro and vivo results, distinct mechanisms action. In this study, triphenyltin(IV) derivatives non-steroidal anti-inflammatory drugs (indomethacin (HIND) flurbiprofen (HFBP)) synthesized characterized, namely [Ph3Sn(IND)] [Ph3Sn(FBP)]. The crystal structure reveals penta-coordination the central tin atom with almost perfect trigonal bipyramidal geometry...
Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as high toxicity may also affect healthy tissues, efficient and selective drug delivery systems tumour tissues needed. Our study focuses on the construction of such for Ru(II) upon exposure a weakly acidic environment tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) utilized, whose surface is functionalized with two types ligands, (2-thienylmethyl)hydrazine...
The main reasons for the limited clinical efficacy of platinum(II)-based agent cisplatin include drug resistance and significant side effects. Due to their better stability, as well possibility introduce biologically active ligands in axial positions constructing multifunctional prodrugs, creating platinum(IV) complexes is a tempting strategy addressing these limitations. Another developing chemotherapeutics with lower toxicity relies on ability nanoparticles accumulate greater quantities...
Abstract A novel series of profluorescent rhodamine nitroxide conjugates are synthesized utilizing well‐known isonitrile‐based multicomponent reactions (IMCRs). The rationally designed as mitochondria‐targeting probes for the detection reactive oxygen species in living cells. Herein, demonstrate high selectivity to target mitochondria both PC3‐ and NIH3T3‐cells which represent cancer normal cell lines. Attaching TEMPO leads fluorescence quenching, allowing ROS quantification. prepared...
Anthraquinone derivatives exhibit various biological activities, e.g., antifungal, antibacterial and in vitro antiviral activities. They are naturally produced many fungal plant families such as Rhamnaceae or Fabaceae. Furthermore, they were found to have anticancer activity, exemplified by mitoxantrone pixantrone, well known redox-active compounds. In this study, nature inspired synthetic anthraquinone tested against colon, prostate, liver cervical cancer cell lines. Most of the compounds...
Peperomia obtusifolia (L.) A. Dietr., native to Middle America, is an ornamental plant also traditionally used for its mild antimicrobial properties. Chemical investigation on the leaves of P. resulted in isolation two previously undescribed compounds, named peperomic ester (1) and peperoside (2), together with five known viz. N-[2-(3,4-dihydroxyphenyl)ethyl]-3,4-dihydroxybenzamide (3), becatamide (4), peperobtusin A (5), peperomin B (6), arabinothalictoside (7). The structures these...
Herein, a new Ugi multicomponent reaction strategy is described to enhance activity and solubility of the chemotherapeutic drug chlorambucil through its conjugation poly(amidoamine) (PAMAM-NH₂) dendrimers with simultaneous introduction lipidic (i-Pr) cationic (⁻NH₂) or anionic (⁻COOH) groups. Standard viability assays were used evaluate anticancer potential water-soluble against PC-3 prostate HT-29 colon cancer cell lines, as well non-cancerous mouse NIH3T3 fibroblasts. It could be...
Multicomponent reactions, especially the Ugi-four component reaction (U-4CR), provide powerful protocols to efficiently access compounds having potent biological and pharmacological effects. Thus, a diverse library of betulinic acid (BA), fusidic (FA), cholic (CA) conjugates with TEMPO (nitroxide) have been prepared using this approach, which also makes them applicable in electron paramagnetic resonance (EPR) spectroscopy. Moreover, convertible amide modified spin-labelled derivatives were...
For the development of anticancer drugs with higher activity and reduced toxicity, two approaches were combined: preparation platinum(IV) complexes exhibiting stability compared to their platinum(II) counterparts loading them into mesoporous silica SBA-15 aim utilise passive enhanced permeability retention (EPR) effect nanoparticles for accumulation in tumour tissues. Three conjugates based on a cisplatin scaffold bearing anti-inflammatory naproxen, ibuprofen or flurbiprofen axial positions...
Abstract Ru(II)‐arene compounds are being investigated as anticancer agents due to the biocompatibility of ruthenium and their structural diversity. Two newly synthesized Ru(II) complexes, [RuCl(η 6 ‐ p ‐cymene)(3‐DNPH)] (chlorido(η ‐cymene)(3‐nitrophenylhydrazine‐k 2 N , ′)ruthenium(II)) ( 1 ) ‐cymene)(3‐CNPH)] (chlorido(3‐chlorophenylhydrazine‐k ′)(η ‐cymene)ruthenium(II)) ), experimentally (IR, NMR) theoretically (B3LYP/6‐31+G(d,p)(H,C,N,Cl)/LanL2DZ(Ru)) characterized. Experimental...
Three novel complexes of deprotonated diflunisal (dif) with neocuproine (neo) were synthesized and characterized by elemental, spectral (UV-Vis, FTIR, fluorescence, mass spectrometry) single-crystal X-ray diffraction analysis. Although, the compounds...
Peptide-drug conjugates (PDCs) have recently gained significant attention for the targeted delivery of anticancer therapeutics, mainly due to their cost-effective and chemically defined production lower antigenicity compared ADCs, among other benefits. In this study, we designed synthesized novel PDCs by conjugating new thiol-functionalized tubulysin analogs (tubugis) bombesin, a peptide ligand with relevant role in cancer research. Two bearing ready-for-conjugation thiol groups were...
Abstract Quinazolinones, particularly 9-azaglycophymines, and closely related derivatives precursors were tested in vitro against various breast cancer cell lines representing the major types of tumors. Among 49 compounds tested, azaglycophymine derivative 19 with an electron-withdrawing substituent demonstrated most significant anti-proliferative effects, IC 50 values around 4 µM. Extensive cell-based investigations revealed that compound induced caspase-dependent apoptosis HCC1937 (human...