A5024911535- Nanoparticle-Based Drug Delivery
- Metal complexes synthesis and properties
- Dendrimers and Hyperbranched Polymers
- Organometallic Complex Synthesis and Catalysis
- Organometallic Compounds Synthesis and Characterization
- Nanoparticles: synthesis and applications
- Thermal and Kinetic Analysis
- Asymmetric Hydrogenation and Catalysis
- Catalytic Alkyne Reactions
- Graphene and Nanomaterials Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
Leipzig University
2023-2024
Merseburg University of Applied Sciences
2021-2024
Organotin(IV) carboxylates are a class of compounds explored as alternatives to platinum-containing chemotherapeutics due propitious in vitro and vivo results, distinct mechanisms action. In this study, triphenyltin(IV) derivatives non-steroidal anti-inflammatory drugs (indomethacin (HIND) flurbiprofen (HFBP)) synthesized characterized, namely [Ph3Sn(IND)] [Ph3Sn(FBP)]. The crystal structure reveals penta-coordination the central tin atom with almost perfect trigonal bipyramidal geometry...
The main reasons for the limited clinical efficacy of platinum(II)-based agent cisplatin include drug resistance and significant side effects. Due to their better stability, as well possibility introduce biologically active ligands in axial positions constructing multifunctional prodrugs, creating platinum(IV) complexes is a tempting strategy addressing these limitations. Another developing chemotherapeutics with lower toxicity relies on ability nanoparticles accumulate greater quantities...
For the development of anticancer drugs with higher activity and reduced toxicity, two approaches were combined: preparation platinum(IV) complexes exhibiting stability compared to their platinum(II) counterparts loading them into mesoporous silica SBA-15 aim utilise passive enhanced permeability retention (EPR) effect nanoparticles for accumulation in tumour tissues. Three conjugates based on a cisplatin scaffold bearing anti-inflammatory naproxen, ibuprofen or flurbiprofen axial positions...
Abstract Oxaliplatin is a third‐generation platinum(II)‐based drug mainly utilized to treat colon cancer, as part of combinatory regime. Aiming expand the knowledge on effects oxaliplatin and its derivatives different tumor types, oxaliplatin‐based platinum(IV) platforms are designed prepared assess their antitumor capacity against various breast cancer cell lines. In two axial positions system, inflammation reducing agents, non‐steroidal anti‐inflammatory drugs (fenoprofen, flurbiprofen,...
A series of heterobimetallic complexes Au/M (M = Rh