A5059670692- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Plant-based Medicinal Research
- Berberine and alkaloids research
- Pancreatic function and diabetes
- Traditional Chinese Medicine Analysis
- Medicinal Plants and Bioactive Compounds
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Neurological Disease Mechanisms and Treatments
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Chromatography in Natural Products
- Inflammatory Bowel Disease
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Traditional Chinese Medicine Studies
- Migraine and Headache Studies
- Autophagy in Disease and Therapy
- Cannabis and Cannabinoid Research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Peroxisome Proliferator-Activated Receptors
University of Macau
2014-2025
Centre for Research and Development
2021-2024
King's College London
2012-2024
Quality Research
2016-2023
British Heart Foundation
2012
Rationale: Ulcerative colitis (UC), a typical kind of inflammatory bowel disease (IBD), is an idiopathic chronic intestinal inflammation.Conventional therapeutic strategies mainly focus on the rebalance pro-inflammation and anti-inflammation cytokines, whereas targeting damaged barriers, imbalanced microbiota dysregulated mucosal immune responses in UC remain big challenge.The objective this study was to develop turmeric-derived nanovesicles (TNVs) for alleviation explore underlying...
Macrophage infiltration and activation is a critical step during acute colitis. Redox-mediated of NLRP3 inflammasomes in macrophages plays role mediating colonic inflammatory responses. Rhein isolated from the rhizome rhubarb exhibits anti-inflammatory effects various diseases. However, its regulating inflammation unexplored. Here, we investigated protective mechanisms rhein gut regulation macrophage activation.Inhibitory on were evaluated activated mouse model Expression mediators,...
Ginsenoside Rk1 activates three peroxisome proliferator-activated receptor (PPAR) isoforms to reduce reactive oxygen species (ROS) and increase nitric oxide (NO) release, thereby improving aortic endothelial function in diabetic obese mice.
Low-grade inflammation in fat is associated with insulin resistance, although the mechanisms are unclear. We report that mice deficient immune cell transcription factor T-bet have lower energy expenditure and increased visceral compared wild-type mice, yet paradoxically more sensitive. This striking phenotype, present young T-bet−/− persisted high-fat diet increasing host age was altered numbers cytokine secretion specifically adipose tissue. However, favorable metabolic phenotype observed...
Abstract Excessive production of reactive oxygen species (ROS) induced by hyperglycemia increased the secretion interleukin-1β (IL-1β), which contributes to pathogenesis diabetes and its complications. Although high glucose (HG)-induced oxidative stress aberrant Ca 2+ channels activity causes an increase in transmembrane influx, however relative contribution Transient receptor potential (TRP) is not well studied. Here, we identified that HG (30 mM for 48 h) activation NLRP3-ASC inflammasome,...
The underlying mechanisms of itch are poorly understood. We have investigated a model involving the chemoattractant leukotriene B4 (LTB4) that is up-regulated in common skin diseases. Intradermal injection LTB4 (0.1 nmol/site) into female CD1 mice induced significant scratching movements (used as an index) compared with vehicle-injected (0.1% bovine serum albumin-saline) mice. Intraperitoneal transient receptor potential (TRP) channel antagonist treatment significantly inhibited follows: TRP...
Abstract Background Coronavirus Disease 2019 (COVID-19) is an unprecedented disaster for people around the world. Many studies have shown that traditional Chinese medicine (TCM) are effective in treating COVID-19. However, it difficult to find most combination herbal pair among numerous herbs, as well identifying its potential mechanisms. Herbal main form of a TCM which widely used treatment diseases. It can also help us better understand compatibility prescriptions, thus improving curative...
Cryptotanshinone (CPT), as a major component of Salvia miltiorrhiza Bunge (Danshen), displays many pharmacological activities including anti-inflammatory effects. However, the exact cellular and molecular mechanisms CPT remain to be elucidated. The present study was aimed clarify its on lipopolysaccharide (LPS)-induced inflammatory responses in mouse macrophages, RAW264.7 cells.In current study, properties were evaluated using LPS-stimulated cell model. MTT assay used determine viability...