A5103161941- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Sex work and related issues
- Pneumonia and Respiratory Infections
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Streptococcal Infections and Treatments
- Adolescent Sexual and Reproductive Health
- Cystic Fibrosis Research Advances
- Clinical practice guidelines implementation
- Otolaryngology and Infectious Diseases
- Artificial Intelligence in Healthcare
- Medicinal Plants and Bioactive Compounds
- Musculoskeletal pain and rehabilitation
- Intracranial Aneurysms: Treatment and Complications
- Meta-analysis and systematic reviews
- Electroconvulsive Therapy Studies
- Bacterial Infections and Vaccines
- Palliative and Oncologic Care
- Spinal Fractures and Fixation Techniques
- Antioxidants, Aging, Portulaca oleracea
- Treatment of Major Depression
- Quality and Safety in Healthcare
Centers for Disease Control and Prevention
2013-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2024
Centers for Disease Control and Prevention
2024
Ministry of Public Health
2011-2022
National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention
2004-2022
University Hospitals of North Midlands NHS Trust
2021
AIDS United
2018
United States Agency for International Development
2018
University of Tennessee at Knoxville
2018
Center for Global Health
2018
Background. In Thailand, phase 1/2 trials of monovalent subtype B and bivalent B/E (CRF01_AE) recombinant glycoprotein 120 human immunodeficiency virus type 1 (HIV‐1) vaccines were successfully conducted from 1995 to 1998, prompting the first HIV‐1 vaccine efficacy trial in Asia.
Abstract We introduce a novel mathematical approach to investigating the spread and control of communicable infections in closed communities. Mycoplasma pneumoniae is major cause bacterial pneumonia United States. Outbreaks illness attributable mycoplasma commonly occur or semi-closed These outbreaks are difficult contain because delays outbreak detection, long incubation period bacterium, an incomplete understanding effectiveness infection strategies. Our model explicitly captures patterns...
Background Mean duration of recent infection (MDRI) and misclassification long-term HIV-1 infections, as proportion false (PFR), are critical parameters for laboratory-based assays estimating incidence. Recent review the data by us others indicated that MDRI LAg-Avidity EIA estimated previously required recalibration. We present here results recalibration efforts using >250 seroconversion panels multiple statistical methods to ensure accuracy consensus. Methods A total 2737 longitudinal...
Objective: To describe participant adherence to daily oral tenofovir in an HIV preexposure prophylaxis (PrEP) trial, examine factors associated with adherence, and assess the impact of on risk infection. Design: The Bangkok Tenofovir Study was a randomized, double-blind, placebo-controlled trial conducted among people who inject drugs, 2005–2012. Methods: Participants chose visits or monthly visits. nurses observed participants swallow study drug both initialed diary. We assessed using...
Tenofovir disoproxil fumarate (tenofovir) has been associated with renal dysfunction in people infected human immunodeficiency virus (HIV) receiving combination antiretroviral therapy. We reviewed data from an HIV preexposure prophylaxis trial to determine if tenofovir use was changes function HIV-uninfected population.
Thailand experienced a generalized human immunodeficiency virus (HIV) epidemic during the 1990s. HIV prevalence among pregnant women was 2.0% and mother-to-child transmission (MTCT) rate >20% (1-3). In June 2016, became first country in Asia to validate elimination of MTCT by meeting World Health Organization (WHO) targets. Because Thailand's experience implementing successful prevention program might be instructive for other countries, interventions, outcomes, factors that contributed...
Introduction Pre‐exposure prophylaxis (PrEP) is recommended by the World Health Organization as an effective method of HIV prevention for individuals at risk infection. In this paper, we describe unique role that Thailand has played in global effort to combat epidemic, including its proving efficacy PrEP, and discuss opportunities challenges implementing PrEP a middle‐income country. Discussion was one first countries world successfully reverse generalized epidemic. Despite early success,...
Background The Bangkok Tenofovir Study was launched in 2005 to determine if pre-exposure prophylaxis with tenofovir will reduce the risk of HIV infection among injecting drug users (IDUs). We describe recruitment, screening, enrollment, and baseline characteristics study participants contrast behavior 1999–2003 AIDSVAX B/E Vaccine Trial. Methods is an ongoing, phase-3, randomized, double-blind, placebo-controlled, trial daily oral tenofovir. Trial were conducted IDUs at 17 drug-treatment...
Abstract Introduction In 2014, the Government of Thailand recommended pre‐exposure prophylaxis (PrEP) as an additional HIV prevention programme within Thailand's National Guidelines on HIV/AIDS Treatment Prevention. However, to date implementation and uptake PrEP programmes have been limited, evidence costs epidemiological economic impact is not available. Methods We estimated associated with provision among men having sex (MSM) participating in a facility‐based, prospective observational...
Antiretroviral therapy reduces the risk of serious illness among people living with HIV and can prevent transmission. We implemented a Test, Treat, Prevent Program men who have sex (MSM) transgender women at five hospitals in four provinces Thailand to increase testing, help those test positive start antiretroviral therapy, access pre-exposure prophylaxis (PrEP).We rapid testing trained staff on immediate initiation offered PrEP two hospitals. recruited MSM walked-in clinics used peer-driven...
Abstract Background Daily dosing of tenofovir disoproxil fumarate, with or without emtricitabine, has high efficacy in preventing human immunodeficiency virus (HIV) infection when individuals are adherent. The target protective plasma concentration (TFV), however, is not fully understood. aim this study to estimate the TFV concentration. Methods Participant data from TFV-based daily oral and topical active arms phase 3 trials (iPrEx, VOICE, Partners PrEP) were pooled (n = 2950). Individual...
In many rural US Appalachian and Midwestern counties, stigma surrounding harm reduction interventions has led health professionals policymakers to approach drug policy implementation with caution, fearing potential backlash from politically conservative communities. One concern is that the public's disapproval of harm-reduction policies may erode trust in its government. This study examined how local government—as both self-reported authority-assessed—is influenced by perceived governmental...
Introduction: Haemophilus influenzae type b (Hib) persists as a major cause of pediatric meningitis and pneumonia in developing countries which Hib conjugate vaccines are not used. Demonstration decreases severe disease after introduce vaccine will help justify the resources necessary to purchase provide vaccine. Because surveillance for culture-confirmed is available many countries, alternative means measure impact would be useful. Methods: Laboratory records from years before introduction...
ABSTRACT Aims To determine if incarceration was associated with human immunodeficiency virus (HIV) infection and identify risk factors for among injection drug users (IDUs) participating in an HIV vaccine trial Bangkok. Design The AIDSVAX B/E a randomized, double‐blind, placebo‐controlled study. A proportional hazards model used to evaluate demographic characteristics, behavior as predictors of generalized estimation equation logistic regression analysis investigate characteristics behaviors...
Introduction HIV spread rapidly among people who inject drugs in Bangkok the late 1980s. In recent years, changes drug use and HIV-associated risk behaviors have been reported. We examined data from Tenofovir Study, an pre-exposure prophylaxis trial conducted drugs, to assess participant behavior use, identify factors for infection. Methods The Study was a randomized, double-blind, placebo-controlled trial. status assessed monthly every 3 months. used generalized estimating equations...
Describe dual contraceptive method use and the intention to become pregnant of people living with HIV (PLHIV) their partners in Thailand.From January 2008-March 2009, we systematically selected a cohort PLHIV from seeking care at five tertiary hospitals one community hospital complete questionnaire assessing sexual activity, pregnant, practices baseline 12 months after enrollment. Participants received short family planning messages every 2-3 promote contraceptives were offered services.A...
HIV testing among men who have sex with (MSM) and transgender (TG) women remains low in Thailand. The prevention program (PREV) to increase link those tested HIV-positive care provided trainings peer educators conduct target mapping, identify high risk MSM TG through outreach education offer them rapid testing. Trained hospital staff counseling same-day results at hospitals mobile clinics referred participants for treatment. We used a standardized pre-test form collect participant...