A5077840166- Child Abuse and Related Trauma
- Child Abuse and Trauma
- Cardiac Arrest and Resuscitation
- Homicide, Infanticide, and Child Abuse
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Restraint-Related Deaths
- Traumatic Brain Injury and Neurovascular Disturbances
- Child and Adolescent Health
- Sepsis Diagnosis and Treatment
- Injury Epidemiology and Prevention
- Airway Management and Intubation Techniques
- Disaster Response and Management
- Ultrasound in Clinical Applications
- Venous Thromboembolism Diagnosis and Management
- Radiation Dose and Imaging
- Neuroendocrine Tumor Research Advances
- Elder Abuse and Neglect
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatic and Hepatic Oncology Research
- Intimate Partner and Family Violence
- Metallurgical Processes and Thermodynamics
- Healthcare Technology and Patient Monitoring
- Homelessness and Social Issues
University of Colorado Denver
2016-2025
University of Colorado Anschutz Medical Campus
2018-2025
Children's Hospital Colorado
2014-2025
Aalto University
2023-2024
University of Colorado Boulder
2024
Kempe Foundation
2019-2021
University of Colorado System
2021
Mayo Clinic
2016-2020
Emerge
2020
WinnMed
2016-2019
ABSTRACT Excitation of neurons in the ventromedial hypothalamus (VMH), especially those residing dorsomedial part nucleus (VMHdm), evokes sympathetic nervous system (SNS) outflow, modulating a number physiological functions including feeding and blood glucose homeostasis. However, anatomical basis VMH‐mediated SNS activation has thus far proved elusive. To understand how VMH exercise output describe an link between these SNS, we identified downstream neural targets VMHdm by injecting...
Child physical abuse is commonly missed, putting abused children at risk for repeated injury and death. Several so-called sentinel injuries have been suggested to be associated with high rates of abuse, imply the need routine testing other, occult traumatic injuries. Our objective was determine evaluation diagnosis among evaluated leading children's hospitals these putative injuries.This a retrospective secondary analysis Pediatric Health Information System database. We identified 30 355...
Siblings and other children who share a home with physically abused child are thought to be at high risk for abuse, but rates of injury in these contact unknown screening contacts is highly variable. Our objective was determine the prevalence abusive injuries identified by common protocol among children.This an observational, multicenter cross-sectional study evaluated physical their contacts, 20 US abuse teams used serious injuries. Contacts underwent examination if they were <5 years old,...
Computed tomography (CT) is commonly used for children when there concern traumatic brain injury (TBI) and a significant source of ionizing radiation. Our objective was to determine the feasibility accuracy fast MRI (motion-tolerant sequences performed without sedation) in young children.In this prospective cohort study, we attempted <6 years old who had head CT were seen emergency department single, level 1 pediatric trauma center. Fast included 3T axial sagittal T2 single-shot turbo spin...
The effect of resonant continuum damping is investigated for the low-mode-number, toroidicity-induced, global shear Alfvén eigenmodes, which can be self-excited by energetic circulating alpha particles in an ignited tokamak plasma. Resonant interaction with possible these especially near plasma periphery, leading to significant dissipation, typically larger than direct bulk dissipation rates. Two perturbation methods are developed obtaining resonance rate from ideal fluid zeroth-order...
abstract Biochemical signs and severity of symptoms primary hyperparathyroidism (pHPT) differ among patients, little is known any coupling clinical characteristics nonfamilial pHPT to genetic abnormalities in the parathyroid tumors. Mutations recently identified MEN1 gene at chromosome 11q13 have been found tumors pHPT. Using microsatellite analysis for loss heterozygosity (LOH) DNA sequencing coding exons, was studied 49 lesions patients with divergent symptoms, operative findings,...
An asymptotic theory is developed to determine the continuum damping of short-wavelength toroidal Alfv\'en eigenmodes, which essential for ascertaining thresholds alpha-particle-driven instability in ignited tokamaks.
OBJECTIVES. In the absence of a gold standard, clinicians and researchers often categorize their opinions likelihood inflicted injury using several ordinal scales. The objective this protocol was to determine reliability expert ratings these METHODS. Participants were pediatricians with substantial academic clinical activity in evaluation children concerns for physical abuse. facts from cases that referred 1 hospital's child abuse team abstracted recorded as multidisciplinary conference....
OBJECTIVE: Although experts recommend routine screening of hepatic transaminases (aspartate aminotransferase [AST] and alanine [ALT]) in cases potential child physical abuse, this practice is highly variable. Our objective was to determine the sensitivity specificity transaminase testing young children who underwent consultation for abuse. PATIENTS AND METHODS: This a prospective, multicenter, observational study all younger than 60 months referred subspecialty evaluation possible The abuse...
Routine testing of hepatic transaminases, amylase, and lipase has been recommended for all children evaluated physical abuse, but rates screening are widely variable, even among abuse specialists, data amylase lacking. A previous study in centers that endorsed routine transaminase suggested using a threshold 80 IU/L could improve injury detection. Our objectives were to prospectively validate the test characteristics 80-IU/L determine utility detect occult abdominal injury.This was...
OBJECTIVE: Follow-up skeletal surveys (FUSS) are performed frequently in cases of possible physical abuse based on the evidence from small retrospective cohorts. Our objective was to determine proportion FUSS that identified new information a large, multicenter population children with concerns abuse. METHODS: This prospective secondary analysis an observational study all &lt;10 years age (120 months) who underwent evaluation for by 20 US child teams. included whom recommended and...
Abstract Background Aberrant accumulation of β-catenin plays an important role in a variety human neoplasms. We recently reported parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). In CTNNB1 exon 3, we detected stabilizing mutation (S37A) 3 out 20 analyzed adenomas. The aim the present study was to determine frequency and zygosity mutations large series Swedish patients. Results S37A (TCT > GCT) by direct DNA sequencing PCR fragments 6 104 sporadic (5.8%). Taking...
Intentional burns represent a serious form of physical abuse that must be identified to protect children from further harm. This study is retrospectively planned secondary analysis the Examining Siblings To Recognize Abuse (ExSTRA) network data. Our objective was describe characteristics injuries in referred Child Pediatricians (CAPs) relation perceived likelihood abuse. We furthermore compare extent diagnostic investigations undertaken CAPs for burn with those other reasons. Within this...
Pancreatic endocrine tumors occur sporadically and as part of the multiple neoplasia type 1 (MEN 1) von Hippel-Lindau (VHL) syndromes. The MEN1 locus on 11q13 a candidate tumor suppressor 3p are known to be hemi- or homozygously mutated in subset these tumors. Chromosome arm 18q harbors SMAD4/DPC4 gene that is frequently deleted inactivated exocrine pancreas. We have analyzed 22 nonfamilial 16 MEN 1-associated pancreatic for loss heterozygosity (LOH) at 3p, 11q13, 18q. LOH was revealed 45%...
Recently, it has been suggested that views of the hands, feet, spine, and pelvis should be omitted from routine skeletal surveys (SSs) because these fractures are rarely identified by SS. Our objective was to describe prevalence or among SSs obtained for children in a large, multicenter population who underwent consultation physical abuse.This retrospective secondary analysis data Examining Siblings To Recognize Abuse research network, consortium 20 U.S. child abuse teams collected all...
Abstract Brain development is dependent on programmed gene expression, which both genetically and epigenetically regulated. Post-transcriptional regulation of expression by microRNAs (miRNAs) essential for brain development. As abnormal hypothesized to be associated with schizophrenia, miRNAs are an intriguing target this disorder. The aims study were determine the temporal dynamics miRNA in human dorsolateral prefrontal cortex (DLPFC), relationship between miRNA’s pattern dysregulation...