A5103242520- Systemic Sclerosis and Related Diseases
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- Dermatologic Treatments and Research
- Hematopoietic Stem Cell Transplantation
- Retinoids in leukemia and cellular processes
- Hops Chemistry and Applications
- Inflammatory Myopathies and Dermatomyositis
- Psoriasis: Treatment and Pathogenesis
- Endometriosis Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Genomics, phytochemicals, and oxidative stress
- Wnt/β-catenin signaling in development and cancer
- Free Radicals and Antioxidants
- Immunotherapy and Immune Responses
- Synthesis and biological activity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metal complexes synthesis and properties
- Uterine Myomas and Treatments
- Organoselenium and organotellurium chemistry
- Urticaria and Related Conditions
- Reproductive System and Pregnancy
- Kruppel-like factors research
- Autoimmune Bullous Skin Diseases
- Selenium in Biological Systems
Institut Cochin
2015-2016
Université Paris Cité
2011-2016
Sorbonne Paris Cité
2012-2016
Hôpital Cochin
2011-2016
Assistance Publique – Hôpitaux de Paris
2011-2016
Inserm
2015-2016
Sorbonne Université
2015
Délégation Paris 5
2011-2015
Abstract Objective In patients with systemic sclerosis (SSc), activated fibroblasts produce reactive oxygen species (ROS) that stimulate their proliferation and collagen synthesis. By analogy tumor cells undergo apoptosis upon cytotoxic treatment increases ROS levels beyond a lethal threshold, we tested whether could be selectively killed by the molecule arsenic trioxide (As 2 O 3 ) in murine model of SSc. Methods SSc was induced BALB/c mice daily intradermal injections HOCl. Mice were...
Abstract Chronic graft-versus-host disease (GVHD) follows allogeneic hematopoietic stem cell transplantation. It results from alloreactive processes induced by minor MHC incompatibilities triggered activated APCs, such as plasmacytoid dendritic cells (pDCs), and leading to the activation of CD4 T cells. Therefore, we tested whether CD4+ pDCs, that produce high levels reactive oxygen species, could be killed arsenic trioxide (As2O3), a chemotherapeutic drug used in treatment acute...
Abstract Objective Systemic sclerosis (SSc) is characterized by microvascular damage, fibrosis of skin and visceral organs, autoimmunity. Previous studies have shown that angiotensin II involved in the synthesis type I collagen. We investigated whether blockade receptor (AT 1 ) irbesartan reduces lung 2 murine models SSc. Methods SSc was induced daily intradermal injection HOCl into backs BALB/c mice (HOCl‐induced SSc). Mice were treated with oral gavage. Results Irbesartan reduced dermal...
Endothelial cell (EC) damage in systemic sclerosis (SSc) is reflected by the shedding of microparticles (MPs). The aim this study was to show that inhibiting MP release using pantethine or inactivating ATP-binding cassette transporter A1 (ABCA1) ameliorates murine SSc. First, effects on and basal oxidative nitrosative stresses ECs fibroblasts were determined vitro. then tested vivo. SSc induced BALB/c mice daily intradermal injection HOCl. Mice simultaneously treated with oral gavage. In...
Renal ischaemia-reperfusion injury (IRI) is consecutive to tissue oxidative damage and cell apoptosis that lead acute renal failure (ARF) in allografts. The aim of this study was investigate the beneficial effects a pretreatment by clopidogrel on IRI mice. induced bilateral ischaemia for 45 min followed reperfusion. Sixty-two healthy male BALB/c mice were randomly assigned one following groups: PBS + (IR); IR; sham IR. Clopidogrel (25 mg/kg) or administered per os animals via gastric cannula...
Systemic sclerosis (SSc) is characterized by fibrosis of the skin and visceral organs, vascular dysfunction, immunologic dysregulation. Platelet-derived growth factors (PDGFs) have been implicated in development dysregulation function. We investigated effects sunitinib sorafenib, two tyrosine kinase inhibitors that interfere with PDGF signaling, a mouse model diffuse SSc.SSc was induced BALB/c mice subcutaneous injections HOCl daily for 6 weeks. Mice were randomized to treatment sunitinib,...
Cancer cells display an overproduction of reactive oxygen species resulting from exaggerated intrinsic oxidative stress. However, the concept deleterious oxidants versus beneficial antioxidants has recently evolved. Indeed, molecules like natural coumarins have shown anti-oxidant or pro-oxidant properties depending on their intracellular concentration. Therefore, we investigated structure-activity relationship a variety coumarin derivatives in terms cytotoxicity towards human and murine...
Abstract Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and visceral organs vascular alterations. SSc pathophysiology involves systemic inflammation oxidative stress. Because vanin-1 gene (vnn1) encodes enzyme with pantetheinase activity that converts vasculoprotective pantethine into profibrotic pantothenic acid pro-oxidant cystamine, we tested this pathway in SSc. Activation vanin-1/pantetheinase was investigated wild-type BALB/c mice hypochlorous...
Organotellurides are newly described redox-catalyst molecules with original pro-oxidative properties. We have investigated the in vitro and vivo antitumoral effects of organotelluride catalyst LAB027 a mouse model colon cancer determined its profile toxicity vivo. induced an overproduction H2O2 by both human HT29 murine CT26 cell lines vitro. This oxidative stress was associated decrease proliferation survival rates two lines. triggered caspase-independent, ROS-mediated death necrosis...
The aim of this study was to test the naturally occurring organosulfur compound dipropyltetrasulfide (DPTTS), found in plants, which has antibiotic and anticancer properties, as a treatment for HOCl-induced systemic sclerosis mouse.The prooxidative, antiproliferative, cytotoxic effects DPTTS were evaluated ex vivo on fibroblasts from normal HOCl mice. In vivo, antifibrotic immunomodulating properties skin lungs mice.H2O2 production higher derived mice than (P < 0.05). did not increase H2O2...