SARS-CoV-2, the novel coronavirus infection has consistently shown an association with neurological anomalies in patients, addition to its usual respiratory distress syndrome. Multi-organ dysfunctions including sequelae during COVID-19 persist even after declining viral load. We propose that SARS-CoV-2 gene product, Spike, is able modify host exosomal cargo, which gets transported distant uninfected tissues and organs can initiate a catastrophic immune cascade within Central Nervous System...

Japanese encephalitis virus (JEV) infection leads to (JE) in humans. JEV is transmitted through mosquitoes and maintained a zoonotic cycle. This cycle involves pigs as the major reservoir, water birds carriers vectors. invasion into central nervous system (CNS) may occur via antipodal transport of virions or vascular endothelial cells. Microglial cells get activated response pathogenic insults. induces innate immune triggers production type I interferons. The signaling pathway interferon...

HIV-1 infection leads to the development of HIV-associated neurological disorders. The Tat protein has been reported exert an adverse effect on blood–brain barrier integrity and permeability. Perturbation in permeability is mainly caused by disruptions adherens junctions tight junction proteins. We have identified C-induced disruption VE-cadherin mediated miRNA-101 human brain microvascular endothelial cells (BMVECs). C increased expression miR-101, which led downregulation VE-cadherin....

Objectives Chikungunya virus causes chronic infection with manifestations of joint pain. Human synovial fibroblasts get infected CHIKV and could lead to pro-inflammatory responses. MicroRNAs have potentials regulate the gene expression various anti-viral genes. The study aims investigate role miR-146a in modulation inflammatory responses human by virus. Methods To pathogenesis cells underlying manifestations, we performed primary fibroblasts. Western blotting, real-time PCR, luciferase...

Abstract Background HIV-1 Tat protein is known to be associated with neuroinflammation, a condition that develops in almost half of patients infected HIV-1. can alter glial neuroprotective functions, leading neurotoxicity within the CNS. secreted from productively cells and affect neighboring uninfected by modulating cellular gene expression bystander fashion. Methods We were interested study whether exogenous exposure Tat-C perturbs microRNA (miRNA) profile human microglial cells, altered...

Abstract Dengue virus (DENV) infection disrupts host innate immune signaling at various checkpoints. Cellular levels and stability of intermediate molecules are a crucial hijacking point for successful viral pathogenesis. Stability turnover all the cellular proteins including principally regulated by proteasomal degradation pathway. In this study, we show that how DENV particularly DENV-NS1 can modulate extracellular vesicle (EV) cargo to manipulate deubiquitination machinery human...

Aims: Evaluation of grafted tomato for resistance to Fusarium wilt under Telangana conditions. Study Design: The poly bag experiment was laid out in Randomized Block Design (RBD). Place and Duration Study: current conducted at College Horticulture, Rajendranagar during Rabi, 2022. Methodology: To find the sources wilt, three graft combinations i.e.T1 – Arka Vikas on Solanum torvum, T2 Surya T3 Keshav along with T4- (Susceptible un check) were screened artificial inoculation conditions bags....

The study was carried out to assess the genetic variability present in ashwagandha and examine nature of associations various traits root yield plant.Fifty-three diverse stocks (Withania somnifera) were evaluated for 14 quantitative characteristics. Analysis variance, correlation, path coefficient analysis performed using mean data 2 years.Analysis variance revealed that genotypes differed significantly all characteristics studied. High heritability conjunction with high advance observed...

Human brain microvascular endothelial cells (hBMVECs) are integral part of the blood barrier. Post-translational modifications adherens junction proteins regulate permeability human cells. Pro-inflammatory signals can induce tyrosine phosphorylation proteins. The primary objective this work is to provide a molecular model; how HIV-1 Tat protein compromise BBB integrity and eventually lead neurological consequences. We exposed hBMVECs recombinant clade C study effect on hBMVECs....

The application of organic amendments in agroecosystems has been widely recommended, but the impact their C/N ratio on stabilization and sequestration soil carbon (SOC) is often unaccounted for. influence physicochemical properties a rice ( Oryza sativa var. NDR97)–barley Hordeum vulgare Lakhan) rotation tropical dryland agroecosystem was compared with an undisturbed grassland. Chemical fertilizer form urea three inputs Sesbania aculeata shoot, low ratio; air‐dried straw wheat Triticum...