A5036561304- Vector-borne infectious diseases
- Viral Infections and Vectors
- Yersinia bacterium, plague, ectoparasites research
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Evolution and Genetic Dynamics
- Insect and Pesticide Research
- Bartonella species infections research
- Dermatological diseases and infestations
- Plant and animal studies
- Plant Parasitism and Resistance
- Zoonotic diseases and public health
New York State Department of Health
2020-2024
Wadsworth Center
2020-2024
University at Albany, State University of New York
2020-2024
Albany State University
2023
Goethe University Frankfurt
2022
University Hospital Frankfurt
2022
Modern infectious disease outbreaks often involve changes in host tropism, the preferential adaptation of pathogens to specific hosts. The Lyme disease-causing bacterium Borrelia burgdorferi ( Bb ) is an ideal model investigate molecular mechanisms because different variants these tick-transmitted bacteria are distinctly maintained rodents or bird reservoir To survive hosts and escape complement-mediated immune clearance, produces outer surface protein CspZ that binds complement inhibitor...
Host association-the selective adaptation of pathogens to specific host species-evolves through constant interactions between and pathogens, leaving a lot yet be discovered on immunological mechanisms genomic determinants. The causative agents Lyme disease (LD) are spirochete bacteria composed multiple species the Borrelia burgdorferi sensu lato complex, including B. (Bb), main LD pathogen in North America-a useful model for study underlying host-pathogen association. requires pathogens'...
In North America, Lyme disease is primarily caused by the spirochetal bacterium Borrelia burgdorferi sensu stricto (Bb), which transmitted between multiple vertebrate hosts and ixodid ticks, a model commonly used to study host-pathogen interactions. While Bb consistently observed in its mammalian avian reservoirs, rarely isolated from American reptiles. Two closely related lizard species, eastern fence (Sceloporus undulatus) western occidentalis), are examples of reptiles parasitized Ixodes...
Transmitted by ticks, the bacterium Borrelia burgdorferi sensu lato is causative agent of Lyme disease (LD), most common vector-borne in Northern hemisphere. No effective vaccines are currently available. B. produces CspZ protein that binds to complement inhibitor, factor H (FH), promoting evasion host system. We previously showed while vaccination with did not protect mice from infection, can be protected after immunization CspZ-Y207A/Y211A (CspZ-YA), a mutant without FH-binding activity....
Lyme borreliosis is the most common vector-borne disease in Northern Hemisphere, caused by spirochetes belonging to Borrelia burgdorferi sensu lato species complex, which are transmitted ixodid ticks. B. produce a family of proteins on linear plasmid 54 (PFam54), some confer functions cell adhesion and inactivation complement, first line host defense. However, impact PFam54 promoting pathogenesis remains unclear because hurdles simultaneously knock out all spirochete. Here, we describe two...
Tick-borne infections are increasing in the United States and around world. The most common tick-borne disease is Lyme caused by infection with spirochete Borrelia burgdorferi ( Bb ), pathogenesis varies from subclinical to severe. transmitted Ixodes ticks, which can carry multiple other microbial pathogens, including Ehrlichia species. To address how simultaneous inoculation of a distinct pathogen impacted course -induced disease, we used C57BL/6 (B6) mice susceptible but develop only mild...
Tolerance and resistance are two host eco-immunological strategies in response to microparasite invasion. In the strategy of "resistance", responses induced decrease replication while "tolerance" allows hosts coexistence with microparasites by minimizing avoid immune-mediated damage. The causative agent Lyme disease is a group genotypically diverse bacterial species, Borrelia burgdorferi sensu lato (Bb), which transmitted Ixodes ticks persists different reservoir animals. North America,...
ABSTRACT Host association– the selective adaptation of pathogens to specific host species – evolves through constant interactions between and pathogens, leaving a lot yet be discovered on immunological mechanisms genomic determinants. The causative agents Lyme disease (LD) are spirochete bacteria composed multiple Borrelia burgdorferi sensu lato complex, including B. ( Bb ), main LD pathogen in North America useful model for study underlying host-pathogen association. requires pathogens’...
ABSTRACT The preferential adaptation of pathogens to specific hosts, known as host tropism, evolves through host-pathogen interactions. Transmitted by ticks and maintained primarily in rodents birds, the Lyme disease-causing bacterium Borrelia burgdorferi ( Bb ) is an ideal model investigate mechanisms tropism. In order survive hosts escape complement-mediated clearance, a first-line immune defense, produces outer surface protein CspZ that binds complement inhibitor factor H (FH) facilitate...
In 1975, many children and adults in Lyme, a coastal town Connecticut, USA, the surrounding areas were suffering from severe joint pain. The doctors did not know what caused this mysterious disease, but they knew that affected had one thing common: been bitten by ticks! Several years later, scientists discovered these ticks carried tiny bacteria inside of them. named Borrelia burgdorferi , reason why those fell ill. are very small have long, corkscrew shape. They can only be observed under...
ABSTRACT Transmitted by ticks, the bacterium Borrelia burgdorferi sensu lato ( Bb sl) is causative agent of Lyme disease (LD), most common vector-borne in Northern hemisphere. No effective vaccines are currently available. sl produces CspZ protein that binds to complement inhibitor, Factor H (FH), promoting evasion host system. We previously showed while vaccination with did not protect mice from infection, can be protected after immunization CspZ-Y207A/Y211A (CspZ-YA), a mutant without...
Abstract Lyme disease is caused by the extracellular pathogen Borrelia burgdorferi ( Bb ), transmitted Ixodes scapularis tick. Approximately one-third of infected individuals develop arthritis weight-bearing joints, though it unclear why some patients and severe systemic while others do not. C57BL/6 (B6) mice are susceptible to infection but not arthritis, providing an in vivo model evaluate mechanisms regulating development arthritis. We demonstrate here that co-infection B6 with tick-borne...