Copper nanostructures represent an important class of materials in CO2 electrocatalytic reduction (CO2ER) reactions, but deciphering their molecular structures, especially those with multiple and irregular organic–inorganic interfaces, remains a grand challenge. Through comprehensive characterization 26-nuclei copper nanocluster [Cu26(DPPE)3(CF3CO2)8(CH3O)2(tBuC≡C)4H11]+ (DPPE is 1,2-bis(diphenylphosphino)ethane), which stabilized by quintuple ligand shells phosphine, carboxylic acid,...

Comprehensive Summary Isochromanone is the core structure of many bioactive compounds. Direct oxidation isochromans one leading methods for construction isochromanones, while most established processes remain suffering from use environmentally unfriendly metal oxidants, harsh reaction conditions, and difficulty in catalyst recycling product separation. Herein, we report a convenient, cost‐effective, green method synthesis high‐value added isochromanones via isochroman oxidations with O 2 by...

In this study, a facile and efficient method to synthesize monofluoroalkenes by photoredox catalytic defluorinative alkylation of gem-difluoroalkenes with 4-alkyl-1,4-dihydropyridines under mild conditions (room temperature) is described. This novel strategy applicable for broad range gem-difluoroalkene substrates good functional group tolerance variety (including primary, secondary, even tertiary alkyl radicals). Moreover, it also allows the challenging radical coupling glycosyl-based...

An efficient visible-light-promoted N-radical-mediated tandem radical cyclization/defluorinated alkylation of β,γ-unsaturated hydrazones, and α-trifluoromethyl alkenes is described. This protocol provides a general effective route to synthesize various dihydropyrazole-fused gem-difluoroalkenes at moderate excellent yields under redox-neutral, metal-free, mild conditions.

Manipulating the interfacial/surface structure of ligand-stabilized atomically precise metal nanoclusters (NCs) is one central tasks in nanoscience because surface motifs are directly related to key properties nanomaterials. Although great progress has been made engineering gold and silver nanoclusters, parallel studies on lighter copper analogues hitherto remain unexplored. In this work, we report design, synthesis, a new class featuring virtually identical kernels but different motifs. The...

Novel copper-hydride nanoclusters of [Cu 14 ( t BuS) 3 (PPh ) 7 H 10 ] + have been prepared. The cluster exhibits intrinsic chirality and helix assembling structures.

We report herein a visible light induced generation of carbanion via double-SET and its application in cyclopropanation alkenes. This new synthetic approach to form cyclopropane derivatives was conducted under mild conditions, using sunlight open air, showing the features such as environmental benignness an easy handle procedure.

Four novel N-heterocyclic carbene (NHC) silver complexes, , have been synthesized and characterized. The single X-ray crystal diffraction data indicate a dinuclear solid-state structure for mononuclear . These complexes successfully used as efficient catalysts the C-H activating carboxylation of terminal alkynes with CO2. A wide range substrates various functional groups afforded corresponding aryl or alkyl substituted propiolic acids in good yields under mild conditions. Moreover, role...

The slow kinetics of the bifunctional (OER/ORR) oxygen electrocatalyst is bottleneck problem restricting performance zinc-air batteries (ZABs). design and synthesis an efficient stable at air cathode to improve ZABs great significance for development sustainable energy conversion devices. Herein, we have developed a sulfur vacancy-rich Mott-Schottky catalyst (Co@Co9S8-NCNT), which shows superior ORR/OER electrochemical activity stability. Specifically, OER overpotential only 210 mV 10 mA...

An efficient and mild Zn-mediated decarboxylative/defluorinative alkylation of α-trifluoromethyl alkenes using N-hydroxyphthalimide esters as radical precursors was developed. Several were readily coupled to a wide range primary, secondary, tertiary radicals, affording the desired gem-difluoroethylenes in moderate excellent yields. This reaction protocol also successfully applied construction complex molecules such bioactive natural dehydroabietic acid glycosyl groups bearing...

DNA base oxidation is considered to be a key event associated with disease initiation and progression in humans. Peroxyl radicals (ROO. ) are important oxidants found cells whose ability react the bases has not been characterized extensively. In this paper, products resulting from ROO. of determined by gas chromatography/MS comparison authentic standards. oxidize adenine guanine their 8-hydroxy derivatives, which biomarkers hydroxyl radical (HO.) oxidations cells. also its hydroxylamine,...

Rhodium(III)-catalyzed remote meta-selective–C-H alkenylation of phenol derivatives has been developed using a traceless organosilicon template as the directing group. This transformation proceeds smoothly with good yields and high meta-selectivities toward series alkene substrates. In addition, this protocol provides an effective strategy for late-stage transformations various meta-alkenylated aromatic compounds.

Comprehensive Summary A visible‐light‐induced tandem radical intramolecular cyclization/arylation of quinoxalin‐2(1 H )‐ones with bromodifluoroacetamides is described. This protocol allows efficient access to a variety valuable α,α ‐difluoro‐ γ ‐lactam‐fused in moderate good yields under metal‐free, mild and redox neutral reaction conditions. strategy tolerant various functional groups broad range substrates. The mechanism experiments suggested an involvement 5‐ exo ‐trig cyclization process...

Abstract A visible‐light‐promoted C−H amidation of (hetero)arenes with hypervalent iodine reagents has been successfully achieved good yields. The high efficiency, broad substrate range and functional group compatibility demonstrated the utility method. Moreover, this protocol was suitable for late‐stage functionalization natural products. Mechanistic studies have shown that N‐centred saccharin radical mediates arenes.

Atomically precise metal nanoclusters have emerged as a prominent area of research in recent years, yet the majority previous studies primarily concentrated on gold and silver ones. The challenge controlling shape copper order to investigate their relationship properties remains significant concern contemporary scientific research. In this study, we successfully achieved control nanocluster with rare flat oblate structure using combination multiple ligands (trifluoroacetic acid,...

Guaiacol is one of major platform compounds derived from lignin. In this work, a series value-added meta-vinylated guaiacols have been successfully synthesized using non-toxic and harmless natural lignin-derived guaiacol...

Boron migration is a type of vital and intriguing reaction in organic synthesis. Herein, new approach for the synthesis gem-difluoroalkenyl boronates via Zn-mediated 1,2-boron radical shift β-boryl NHPI esters developed. These alkyl radicals subsequently undergo to produce valuable species, which can be further trapped by α-trifluoromethyl alkenes construct diverse array boronates, including pharmaceutical molecules. Moreover, this cross-coupling process used late-stage modification...

A traceless organosilicon template-directed meta-selective-C-H alkenylation of phenols was realized with good yields and high selectivities. The template readily removable through F--promoted O-Si cleavage under extremely mild conditions or recyclable a p-TSA catalyzed process. product successfully applied in the preparation series meta-alkenylated aromatic compounds.

Although aquaporins (AQPs) play important roles in transcellular water movement, their precise quantification and localization remains controversial. We investigated expression levels localizations of AQP3 AQP8 possible functions the rat digestive system using real-time polymerase chain reactions, western blot analysis immunohistochemistry. esophagus, forestomach, glandular stomach, duodenum, jejunum, ileum, proximal distal colon, liver. was expressed basolateral membranes stratified...