A5004019711- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Peptidase Inhibition and Analysis
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Reconstructive Surgery and Microvascular Techniques
- Lung Cancer Research Studies
- Particle Detector Development and Performance
- Parathyroid Disorders and Treatments
- Liver Disease and Transplantation
- Ear and Head Tumors
- Liver Disease Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Biomedical Research and Pathophysiology
- Bone health and treatments
- Dysphagia Assessment and Management
- Airway Management and Intubation Techniques
- Neurological diseases and metabolism
- Diabetes and associated disorders
- Cancer, Hypoxia, and Metabolism
- Healthcare Systems and Practices
- Medical and Biological Sciences
University of Lausanne
2015-2024
University Hospital of Lausanne
2015-2024
GTx (United States)
2019-2024
Deleted Institution
2023
Hôpital Beau-Séjour
2022
Inter Metal (Poland)
2022
University of Liverpool
2021
Hospital Italiano de Buenos Aires
2021
Royal Brisbane and Women's Hospital
2021
Institut Gustave Roussy
2021
Abstract There are significant commonalities among several pathologies involving fibroblasts, ranging from auto-immune diseases to fibrosis and cancer. Early steps in cancer development progression closely linked fibroblast senescence transformation into tumor-promoting cancer-associated fibroblasts (CAFs), suppressed by the androgen receptor (AR). Here, we identify ANKRD1 as a mesenchymal-specific transcriptional coregulator under direct AR negative control human dermal (HDFs) key driver of...
Importance: Head and neck cancers often require complex, labor-intensive surgeries, especially when free flap reconstruction is required. Enhanced recovery important in this patient population but evidence-based protocols on perioperative care for are lacking. Objective: To provide a consensus-based protocol optimal of patients undergoing head cancer surgery with reconstruction. Evidence Review: Following endorsement by the Recovery After Surgery (ERAS) Society to develop protocol,...
Current treatment guidelines for patients with locally advanced head and neck squamous cell carcinoma (HNSCC) recommend multimodal treatment, including chemoradiation therapy (CRT) or surgery followed by radiation, without chemotherapy. The immune checkpoint inhibitor pembrolizumab has previously demonstrated antitumor activity in recurrent and/or metastatic HNSCC large Phase III trials. For disease, Ib data on the use of combination have shown approach to be safe feasible. We describe here...
Both practice environment and patient clinical demographic characteristics are associated with cancer trial enrollment; simultaneous intervention may be required when trying to increase enrollment rates.
To access the long-time outcome and patterns of failure in patients with advanced head neck squamous cell carcinoma (HNSCC). Between 1992 2005 127 (median age 55 years, UICC stage III n = 6, IV 121) primarily inoperable, HNSCC were treated definite platinum-based radiochemotherapy dose 66.4 Gy). Analysed end-points overall survival (OS), disease-free (DFS), loco-regional progression-free (LPFS), development distant metastases (DM), prognostic factors causes death. The mean follow-up time was...
Abstract Background We aimed to estimate minimally important difference (MID) for interpreting group‐level change over time European Organisation Research and Treatment of Cancer Quality Life Questionnaire core 30 (EORTC QLQ‐C30) scores in head neck cancer. Methods Data were derived retrospectively from two published EORTC trials. Clinical anchors selected using correlation strength clinical plausibility the given anchor/QLQ‐C30 scale pair. MIDs within‐group between‐group estimated via mean...
Abstract Purpose: The incidence of human papillomavirus–associated head and neck squamous cell carcinoma (HPV+-HNSCC) is rising worldwide although current therapeutic modalities are efficient in the majority patients, there a high rate treatment failures. Thus, novel combination approaches urgently needed to achieve better disease control patients with HPV+-HNSCC. We investigated safety efficacy fibroblast activation protein (FAP)-targeted CD40 agonist (FAP-CD40) local hypofractionated...
Abstract Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising multiple body sites, including skin Head/Neck. loss by gene silencing or deletion reduces proliferation clonogenicity human keratinocytes SCC-derived cells affects transcription impinging on stem cell-related...
Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains a common event associated with dismal prognosis. Improving this outcome requires better understanding of cancer populations that expand from postsurgical minimal residual disease (MRD). Therefore, we assessed clonal dynamics in surgical model barcoded HNSCC growing the submental region immunodeficient mice. Clonal substitution massive reduction heterogeneity emerged as hallmarks local recurrence, clones...
Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality life in patients head and neck cancers. Novel surgical radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses current literature outcomes curative treatment strategies. Available results from recent studies relevant this topic are presented,...