A5001066787- Cell death mechanisms and regulation
- Nuclear Structure and Function
- Cancer-related Molecular Pathways
- Synthesis and Characterization of Heterocyclic Compounds
- Laser Applications in Dentistry and Medicine
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Spaceflight effects on biology
- Cancer, Hypoxia, and Metabolism
- Chromium effects and bioremediation
- Electromagnetic Fields and Biological Effects
- Molecular Biology Techniques and Applications
- Polyoxometalates: Synthesis and Applications
- Cancer Cells and Metastasis
University of Lausanne
2023-2024
Harvard University
2024
University of Belgrade
2016-2017
Abstract There are significant commonalities among several pathologies involving fibroblasts, ranging from auto-immune diseases to fibrosis and cancer. Early steps in cancer development progression closely linked fibroblast senescence transformation into tumor-promoting cancer-associated fibroblasts (CAFs), suppressed by the androgen receptor (AR). Here, we identify ANKRD1 as a mesenchymal-specific transcriptional coregulator under direct AR negative control human dermal (HDFs) key driver of...
In this paper we introduce cocycle hunter (cHunter), a tool for identifying and exploiting diverse circular structure in single-cell RNAseq data. Our method is based on persistent cohomology dimension one, which use to define system of statistically enriching gene sets structure. We also develop powerful, cohomology-based technique estimating the phase genes exhibiting cyclic expression patterns. validate our synthetic RNA transcription models, as well real datasets studying cell cycle,...
Alterations of nuclear structure and function, associated impact on gene transcription, are a hallmark cancer cells. Little is known these alterations in Cancer-Associated Fibroblasts (CAFs), key component the tumor stroma. Here we show that loss androgen receptor (AR), which triggers early steps CAF activation human dermal fibroblasts (HDFs), leads to membrane increased micronuclei formation, unlinked from induction cellular senescence. Similar occur fully established CAFs, overcome by...
Aim: Investigation of cytotoxic effects newly synthesized and untested polyoxometalates Pd1 Pd2 on human neuroblastoma cells SH-SY5Y. Introduction: Polyoxometalates (POMs) are transitional metal complexes, which important in medicinal chemistry, as potent anticancer, antiviral antibacterial agents. Inefficiently selective drugs problems with dosing usual chemotherapeutics directed the research towards investigation new agents, such POM. Methods: Effects viability rate treated was tested...