A5066929539- Venous Thromboembolism Diagnosis and Management
- Monoclonal and Polyclonal Antibodies Research
- Atrial Fibrillation Management and Outcomes
- Glycosylation and Glycoproteins Research
- Soil and Water Nutrient Dynamics
- Diagnosis and Treatment of Venous Diseases
- Aquatic Ecosystems and Phytoplankton Dynamics
- Bacteriophages and microbial interactions
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- HER2/EGFR in Cancer Research
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Radiopharmaceutical Chemistry and Applications
- Cutaneous lymphoproliferative disorders research
- Prostate Cancer Treatment and Research
- Peptidase Inhibition and Analysis
- Marine and coastal ecosystems
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- GDF15 and Related Biomarkers
- Vascular Tumors and Angiosarcomas
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Apelin-related biomedical research
Molecular Partners (Switzerland)
2012-2025
Medical University of Vienna
2022-2025
Epworth Hospital
2023-2025
Aarhus University Hospital
2023
Pädagogische Hochschule Bern
2023
Comprehensive Cancer Center Vienna
2022
University of Tübingen
2021
Medical University of Graz
2020-2021
University of Rochester Medical Center
2021
Swiss Federal Institute of Aquatic Science and Technology
2000-2020
Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with potential resistance to existing drugs emphasizes the need for new therapeutic modalities broad variant activity. Here we show that ensovibep, a trispecific DARPin (designed ankyrin repeat protein) clinical candidate, can engage three units spike protein trimer SARS-CoV-2 and inhibit ACE2 binding high potency, as revealed by cryo-electron microscopy analysis. cooperative together...
AME Aquatic Microbial Ecology Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsSpecials 22:271-282 (2000) - doi:10.3354/ame022271 biomass, growth, and respiration associated with submerged litter of Phragmites australis decomposing in a littoral reed stand large lake D. Komínková*, K. A. Kuehn**, N. Büsing, Steiner, M. O. Gessner*** Department Limnology, Swiss Federal Institute for Environmental Science...
A long systemic half-life is key for therapeutic proteins. To that end we have generated serum albumin-binding designed ankyrin repeat domains. These domains bind albumin of different species with nanomolar affinities, and significantly improved pharmacokinetic properties both in mouse cynomolgus monkey compared to non-serum DARPin® In addition, they exhibit high thermal stability storage stability, which an essential feature their use drug development. Covalently linking a domain other...
The hemostatic system is tightly interconnected with cancer. Research has focused predominantly on thrombotic complications, but less known about bleeding and risk prediction. Growth differentiation factor (GDF)-15 previously emerged as a prognostic biomarker for bleeding. aim of this study was to investigate the association predictive ability GDF-15 in patients CAT-BLED (Vienna Cancer, Thrombosis, Bleeding) prospective, observational cohort including cancer initiating systemic anticancer...
There is mounting evidence that organic or inorganic enrichment of aquatic environments increases the risk infectious diseases, with disease agents ranging from helminth parasites to fungal, bacterial, and viral pathogens. The causal link between microbial resource availability thought be complex and, in case so‐called “opportunistic pathogens,” involve additional stressors weaken host resistance (e.g., temperature shifts oxygen deficiencies). In contrast this perception, our experiment...
Summary 1. Three common species of freshwater phytoplankton, the diatom Nitzschia sp., green alga Sphaerocystis schroeteri and cyanobacterium Phormidium luridum , were grown under contrasting daylengths [18 : 6 h light dark cycles (LD) versus 18 LD] phosphorus (P) regimes (P‐sufficient 1 μ m P). The rates growth photosynthesis, as well efficiencies pigment concentrations, compared among treatments. 2. photosynthetic parameters three depended on both P status daylength in a species‐specific...
We examined the effects of environmental conditions on microbially mediated CO2 evolution from standing-dead litter (leaf blades, leaf sheaths, and culms) common reed, Phragmites australis (Cav.) Trin. ex Steud., in two temperate littoral freshwater marshes. Water availability was major factor affecting rates. In laboratory, microbial assemblages responded rapidly to controlled additions water, with large increases occurring within five minutes after wetting (e.g., blades: 10–295 μg CO2-C·(g...
Abstract Globally accessible therapeutics against SARS-CoV-2 are urgently needed. Here, we report the generation of first anti-SARS-CoV-2 DARPin molecules with therapeutic potential as well rapid large-scale production capabilities. Highly potent multivalent low picomolar virus neutralization efficacies were generated by molecular linkage three different monovalent molecules. These target various domains spike protein, thereby limiting possible viral escape. Cryo-EM analysis individual...
Abstract Radioligand therapy has shown strong clinical potential for the treatment of certain neuroendocrine and prostate tumors. Nevertheless, effective strategies in various cancer types are currently restricted by lack appropriate targeting agents suitable tumor-associated antigens. Not expressed healthy tissue, DLL3 is one these promising targets highly upregulated SCLC other high-grade Herein we present preclinical results our DLL3-targeting 212Pb-based Radio-DARPin Therapeutic (RDT)...
With the availability of PSMA-PET scans, it is controversial whether pelvic lymph-node dissection (PLND) at time radical prostatectomy (RP) still most reliable and accurate staging modality for assessment. Furthermore, oncological benefit PLND remains unclear. Aim this study was to assess omitting in patients undergoing RP prostate cancer associated with risk tumor recurrence progression metastasis. In longitudinal multicentre cohort-study, we reviewed data 2346 consecutive who underwent...
Patients with venous thromboembolism (VTE) are at risk of bleeding during anticoagulation. To assess and the performance assessment models (RAMs) VTE-PREDICT, HAS-BLED, RIETE, VTE-BLEED in patients acute VTE initiating We utilized data from a prospective observational cohort study (BACH-VTE) including who initiated anticoagulation follow-up period up to two years. Exclusion criteria were active cancer, pregnancy, postpartum period. Major, clinically relevant non-major (CRNMB), minor recorded...