A5085828550- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- CAR-T cell therapy research
- COVID-19 epidemiological studies
- COVID-19 Impact on Reproduction
- Monoclonal and Polyclonal Antibodies Research
- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- COVID-19 Pandemic Impacts
- History of Medicine Studies
- Historical and Religious Studies of Rome
- Radiation Dose and Imaging
- Sports injuries and prevention
- Sleep and Work-Related Fatigue
- Healthcare professionals’ stress and burnout
- Tuberculosis Research and Epidemiology
- Classical Antiquity Studies
- RNA Interference and Gene Delivery
- Hip disorders and treatments
- Respiratory viral infections research
- Shoulder Injury and Treatment
- Social Sciences and Policies
University of Milano-Bicocca
2020-2025
Molecular Partners (Switzerland)
2020-2025
Azienda Ospedaliera San Gerardo
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2025
Azienda Socio Sanitaria Territoriale Lariana
2022
Hospital of Prato
2021
Primary Source
2020
Foraggere e Lattiero Casearie
2013
Although many workers may be exposed to the novel coronavirus, healthcare (HCWs) have an increased risk of contracting COVID-19 due their close contact with patients affected by SARS-CoV-2 [[1]Belingheri M. Paladino M.E. Riva M.A. COVID-19: health prevention and control in non-healthcare settings.Occup Med. 2020; https://doi.org/10.1093/occmed/kqaa048Crossref Scopus (47) Google Scholar,[2]Koh D. Occupational risks for COVID-19.Occup https://doi.org/10.1093/occmed/kqaa036Crossref (317)...
Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with potential resistance to existing drugs emphasizes the need for new therapeutic modalities broad variant activity. Here we show that ensovibep, a trispecific DARPin (designed ankyrin repeat protein) clinical candidate, can engage three units spike protein trimer SARS-CoV-2 and inhibit ACE2 binding high potency, as revealed by cryo-electron microscopy analysis. cooperative together...
Abstract Background In next fall and winter, SARS-CoV-2 could circulate in parallel with seasonal influenza. The dual epidemics will result considerable morbidity mortality; therefore, influenza vaccination may be essential. Recent studies found increased risk of coronavirus individuals receiving vaccination. Aims Our aim is to analyse the association between COVID-19 a population healthcare workers (HCWs). Methods IgG antibodies against were detected 3520 HCWs at large hospital Northern...
Abstract Globally accessible therapeutics against SARS-CoV-2 are urgently needed. Here, we report the generation of first anti-SARS-CoV-2 DARPin molecules with therapeutic potential as well rapid large-scale production capabilities. Highly potent multivalent low picomolar virus neutralization efficacies were generated by molecular linkage three different monovalent molecules. These target various domains spike protein, thereby limiting possible viral escape. Cryo-EM analysis individual...
Dr. Livia Lollini, a physician and an early pioneer in women's occupational health, authored paper published as the lead article inaugural issue of La Medicina del Lavoro, which adopted its current title 1925. Her work, protezione della donna e fanciullo sul lavoro (The Protection Women Children at Work), constitutes one her contributions to labor protections for women children 20th-century Italy. Born into family distinguished by socialist feminist ideals, she completed medical education...
Paladino, Maria Emilia MD; Riva, Michele Augusto MD, PhD; Mattei, Federico Perconte, Claudio Soriano, Antonio Belingheri, Michael MD Author Information
Galen of Pergamon (128-216 AD) is one the most renowned physicians antiquity, known for his extensive contributions to various medical disciplines. His early career included treating traumatic injuries, which developed knowledge human anatomy and surgical techniques. The aim this work analyze history pediatric surgery. Galen’s in surgery notable its detailed case reports methods, such as using healing poultices. He emphasized necessity only when required, criticizing colleagues who...
The compromise between affinity and specificity in TCR-dependent targeting of HLA-restricted tumor-associated antigens presents a significant challenge developing efficacious immunotherapies. As such, T cell engagers which circumvent these limitations are particular interest. We have established process to generate bispecific Designed Ankyrin Repeat Proteins (DARPins) that simultaneously target HLA-I molecules complex with peptides CD3ϵ. High-affinity HLA-A*0201/NY-ESO1 157-165 -specific...
Radioligand therapies have emerged as promising treatment modality for certain cancers. This therapeutic approach relies on a suitable tumor-targeting moiety labelled with radioactive payload to allow the delivery of radionuclide cancer cells high specificity. Due its expression profile in tumor vs healthy tissues, MSLN is an attractive protein targeted therapies. GPI-anchored membrane which overexpressed many types, including ovarian and pancreatic adenocarcinoma. Therapeutic approaches...
Background: University students are known to have higher sleep disorders prevalence than the general population. Among them, nursing even more susceptible disorders. This study evaluates disorders’ risk factors among and their potential association with symptoms assesses whether night shifts affect quality by increasing of Methods: A total 202 were included; a self-administered questionnaire was used collect data on sociodemographic academic characteristics (i.e., gender, age, height,...
Abstract SARS-CoV-2 has infected millions of people globally and continues to undergo evolution. Emerging variants can be partially resistant vaccine induced immunity therapeutic antibodies, emphasizing the urgent need for accessible, broad-spectrum therapeutics. Here, we report a comprehensive study ensovibep, first trispecific clinical DARPin candidate, that simultaneously engage all three units spike protein trimer potently inhibit ACE2 interaction, as revealed by structural analyses. The...
Objective: To determine the incidence of COVID-19 and duration sick leave among asymptomatic healthcare workers (HCWs) after vaccination with BNT162b2. Methods: From October 2020 to March 2021, we determined in a cohort 671 HCWs before vaccination. We also analyzed days required obtain negative RT-PCR result infection. Results: Prior 105 (15.6%) were positive. Positive cases reduced 42 (7.5%) period ( P < 0.0001). A was observed at first control 80% vaccinated only 37% Conclusions: Even...
To the Editor: Readers are invited to submit letters for publication in this department. Submit online at http://joem.edmgr.com. Choose "Submit New Manuscript." A signed copyright assignment and financial disclosure form must be submitted with letter. Form available www.joem.org under Author Reviewer information. recent from European Centre Disease Prevention Control (ECDC) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission reported that few data about disease...