Background . Diabetes mellitus has become a major public health and economic problem across the globe. The inadequacies, as well serious adverse effects associated with conventional medicines, led to determined search for alternative natural therapeutic agents. leaf latex extract of Aloe megalacantha been used management diabetes in Ethiopian folk medicine. This study aimed evaluate antidiabetic antihyperlipidemic A. streptozotocin- (STZ-) induced diabetic model. Methods experimental was...

Tuberculosis (TB) is a global health problem complicated by drug resistance and human immunodeficiency virus that has dramatically increased active TB. Several medicinal plants are used traditionally to treat TB in Ethiopia investigating these required as an alternative source for development of new anti-TB drugs. The purpose this study was investigate antimycobacterial activity crude extract Carissa edulis, Otostegia integrifolia, Persea americana, Pterolobium stellatum Vernonia amygdalina...

Individuals with substance use disorder are prone to develop different psychiatric disorders. Substance abuse and associated problems of current global concern that leads mental health disorders which contributed about 14% the burden disease. It has become an epidemic in some parts African region adolescents being main victims ill social effects use. This study is aimed at assessing prevalence depression, anxiety, stress factors among khat chewers Amhara region, 2019. A community-based...

Most of herbal medicines are used without any standard safety and toxicological trials although common assumption is that these products nontoxic. However, this incorrect dangerous, so studies should be done for drugs. Although Pterolobium stellatum, Otostegia integrifolia Vernonia amygdalina root extracts frequently in Ethiopian traditional medicine, there no evidences their active toxic compounds. Therefore, we made an effort to assess probable genotoxic effect plant on DNA human hematoma...

Elderly people are most commonly associated with cardiac disease. Cardiovascular diseases interlinked co-morbidities which require multiple drug therapy in addition to cardiovascular drugs. This results polypharmacy carries a high risk of potential drug-drug interactions. patients at particular related problems because increased level and the physiological changes accompany aging. study was aimed assess interactions (DDIs) among elderly Yekatit 12 hospital.A retrospective cross-sectional...

Currently, there is a demand for new antidiabetic drugs from natural therapeutic agents, and diabetes mellitus disease global epidemic. The leaf of Hypoestes forskaolii has been used in the traditional health system management Ethiopia Eritrea. aim this study was to evaluate vivo antidiabetic, antihyperlipidemic vitro antioxidant activity extract solvent fractions H. (Vahl) mice.The blood glucose-lowering activities were screened normoglycemic, glucose loaded, streptozotocin-induced diabetic...

Background: In Ethiopia, malaria control has been complicated due to resistance of the parasite and its vectors current drugs. Therefore, new drugs are required avert problem posed by drug-resistant Plasmodium strains. There is need investigate alternative sources antimalarial agents plants potential source This study aimed activity leaves N. congesta crude extract (hydromethanolic extract) solvent fractions (n-hexane, chloroform, aqueous traditionally used treat in many parts Ethiopia....

Diarrheal diseases are associated with an estimated 1.3 million deaths annually, most occurring in resource-limited countries; up to 25% of young children living Africa and southeast Asia attributable acute gastroenteritis. Due limitations various treatments available, the need for developing newer drugs is imperative.This study was aimed evaluate antidiarrheal activity root extract fractions C. abyssinica Jaub. & Spach. (Euphorbiaceae) mice.After plant extraction subsequent fractionation...

Farmers use a large number of pesticides to increase the productivity Khat cultivation. Since is consumed by many Ethiopians as habit, there may be significant concentration pesticide residues in leaves which result adverse effects among exposed population. Excess causes cancer, genotoxicity, and endocrine disturbances. The current study aimed determine selected on samples estimate possible health risk consumers. Thirty were collected from cultivators Amhara region, Ethiopia. Pesticide...

Brassica carinata is one of the traditional medicinal plants used in Ethiopia for treatment wounds and other diseases. However, plant has not been scientifically validated, thus present study evaluated vitro anti-oxidant vivo wound healing activity crude extract solvent fractions B. seeds mice.The was prepared by maceration using 80% methanol formulated as 5% 10% w/w ointments topical application. The acute dermal toxicity performed female albino rats based on Organization Economic...

Wounds significantly affect people's quality of life and the clinical financial burden healthcare systems around world. Many current drugs used to treat wounds have problems such as; allergies drug resistance. Hence, exploration new therapeutic agents from natural origin may avert this problem. Clerodendrum myricoides long been in Ethiopia. Despite this, nothing has so far reported about wound healing anti-inflammatory activity C. myricoides. This study aimed evaluate 80% methanol extract...

The leaves of Trichilia dregeana Sond are traditionally used to treat wounds. Even though there have been in vitro studies and claims supporting wound healing, no scientific data on vivo healing anti-inflammatory activities the T. dregeana.This study aimed evaluate activity 80% methanol crude extract solvent fractions mice.The were dried, ground, macerated with three times successively. was fractioned by water, ethyl acetate, hexane separately. acute dermal oral toxicity tests done applying...