A5041539465- Medical Imaging Techniques and Applications
- Orthopedic Surgery and Rehabilitation
- Cancer, Hypoxia, and Metabolism
- Advanced X-ray and CT Imaging
- Rheumatoid Arthritis Research and Therapies
- Radiomics and Machine Learning in Medical Imaging
- Radiation Detection and Scintillator Technologies
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Orthopedic Infections and Treatments
- Diet and metabolism studies
- Spondyloarthritis Studies and Treatments
- Elbow and Forearm Trauma Treatment
- Nutrition and Health in Aging
- Amino Acid Enzymes and Metabolism
- MRI in cancer diagnosis
- Sarcoma Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- Spectroscopy Techniques in Biomedical and Chemical Research
- Shoulder Injury and Treatment
- Pesticide Exposure and Toxicity
- Neuroscience and Neuropharmacology Research
University of California, Davis
2016-2025
California State University, Sacramento
2023
University of California Davis Medical Center
2009-2023
Rwanda Development Board
2021
American Jewish Committee
2021
Assiut University
2017
University of Southern California
2003-2008
Southern California University for Professional Studies
2005-2007
For bioluminescence imaging studies in small animals, it is important to be able accurately localize the three-dimensional (3D) distribution of underlying bioluminescent source. The spectrum light produced by source that escapes subject varies with depth emission because wavelength-dependence optical properties tissue. Consequently, multispectral or hyperspectral data acquisition should help 3D localization deep sources. In this paper, we describe a framework for fully tomographic image and...
Abstract Many cancers appear to activate intrinsic antioxidant systems as a means counteract oxidative stress. Some cancers, such clear cell renal carcinoma (ccRCC), require exogenous glutamine for growth and exhibit reprogrammed metabolism, at least in part due the glutathione pathway, an efficient cellular buffering system that counteracts reactive oxygen species other oxidants. We show here ccRCC xenograft tumors under capsule enhanced stress compared with adjacent normal tissue...
We have constructed a dedicated breast PET/CT scanner capable of high-resolution functional and anatomic imaging. Here, we present an initial characterization performance during patient <b>Methods:</b> The system consisted lutetium oxyorthosilicate–based dual–planar head PET camera (crystal size, 3 × 20 mm) 768-slice cone-beam CT. position the heads (separation height) could be adjusted for varying dimensions. For scanning, lay prone on specialized bed inserted single pendent through...
Abstract INTRODUCTION The understanding of the pathological events in Alzheimer's disease (AD) has advanced dramatically, but successful translation from rodent models into efficient human therapies is still problematic. METHODS To examine how tau pathology can develop primate brain, we injected 12 macaques with a dual mutation (P301L/S320F) entorhinal cortex (ERC). An investigation was performed using high‐resolution microscopy, magnetic resonance imaging (MRI), positron emission tomography...
We investigate fast iterative image reconstruction methods for fully 3D multispectral bioluminescence tomography applications in small animal imaging. Our forward model uses a diffusion approximation optically inhomogeneous tissue, which we solve using finite element method (FEM). examine two approaches to incorporating the into solution of inverse problem. In conventional direct calculation approach one computes full by repeated FEM problem, once each potential source location. describe an...
Objective: Rheumatoid arthritis (RA) and psoriatic (PsA) commonly affect the small joints of wrist hand. We evaluated performance a new, high-resolution extremity positron emission tomography (PET)/CT scanner for characterizing quantifying pathologies associated with two arthritides in hand joints. Methods: Patients RA or PsA underwent fluorine-18 fludeoxyglucose (18F-FDG) PET/CT imaging, respectively, on scanner. Calibrated CT images co-registered PET were reconstructed. was derived...
Autoimmune inflammatory arthritides (AIA), such as psoriatic arthritis and rheumatoid arthritis, are chronic systemic conditions that affect multiple joints of the body. Recently, total-body (TB) PET/CT scanners exhibiting superior technical characteristics (total-body coverage, geometric sensitivity) could benefit AIA evaluation, compared with conventional systems, have become available. The objectives this work were to assess performance an ultra-low-dose, 18F-FDG TB acquisition protocol...
Background Non-invasive imaging techniques such as magnetic resonance (MRI) provide the ability to evaluate complex anatomy of bone and soft tissues wrist without use ionizing radiation. Dynamic instability – occurring during joint motion is a condition that has assumed increased importance in musculoskeletal medicine. The objective this study was develop an MRI protocol for evaluating continuous active motion, show dynamic realizable, demonstrate resulting anatomical images enable...
Eur J Nucl Med Mol Imaging (2010) 37:1047 DOI 10.1007/s00259-009-1364-x IMAGE OF THE MONTH High-resolution 18 F-FDG PET with MRI for monitoring response to treatment in rheumatoid arthritis Abhijit J. Chaudhari & Spencer L. Bowen George W. Burkett Nathan Packard Felipe Godinez Anand A. Joshi Stanley M. Naguwa David K. Shelton John C. Hunter Boone Michael H. Buonocore Ramsey D. Badawi Received: 20 November 2009 / Accepted: 10 December Published online: 30 January 2010 # The Author(s) 2010....
We present a method based on spectral theory for the shape analysis of carpal bones human wrist.We represent cortical surface bone in coordinate system eigensystem two-dimensional Helmholtz equation.We employ metric-global point signature (GPS)-that exploits scale and isometric invariance eigenfunctions to quantify overall shape.We use fast finite-element-method compute GPS metric.We capitalize upon properties representation-such as stability, standard Euclidean (ℓ 2 ) metric definition,...
Abstract Context Studies in rodents and humans suggest that high-fructose corn syrup (HFCS)–sweetened diets promote greater metabolic dysfunction than sucrose-sweetened diets. Objective To compare the effects of consuming beverage (SB), HFCS-SB, or a control sweetened with aspartame on outcomes humans. Methods A parallel, double-blinded, NIH-funded study. Experimental procedures were conducted during 3.5 days inpatient residence controlled feeding at research clinic before (baseline) after...
Detection of atherosclerotic plaque vulnerability has critical clinical implications for avoiding sudden death in patients with high risk rupture.We report on multimodality imaging ex-vivo human carotid samples using a system that integrates fluorescence lifetime (FLIM), ultrasonic backscatter microscopy (UBM), and photoacoustic (PAI).Biochemical composition is differentiated temporal resolution sensitivity at the surface by FLIM subsystem.3D microanatomy whole reconstructed UBM.Functional...
Abstract Acute intoxication with organophosphates (OPs) can trigger status epilepticus followed by persistent cognitive impairment and/or electroencephalographic abnormalities. Neuroinflammation is widely posited to influence these neurological consequences. However, testing this hypothesis has been challenging, in part because traditional biometrics preclude longitudinal measures of neuroinflammation within the same animal. Therefore, we evaluated performance noninvasive positron emission...
To determine the relationship between adipose tissue and skeletal muscle measurements on computed tomography (CT) overall survival major postoperative complications in patients with soft-tissue sarcoma (STS).The retrospective study included 137 STS (75 men, 62 women; mean age, 53 years, SD 17.7; BMI, 28.5, 6.6) who had abdominal CT exams. On a single image, at L4 pedicle level, of visceral (VAT), subcutaneous (SAT), area attenuation were obtained using clinical PACS specialized segmentation...
Past efforts to measure blood flow with the widely available radiotracer 18F-FDG were limited tissues high extraction fraction. In this study, we developed an early dynamic PET method high-temporal-resolution (HTR) kinetic modeling assess total-body based on deriving vascular phase of transit and conducted a pilot comparison study against 11C-butanol flow-tracer reference. Methods: The first 2 min scans reconstructed at HTR (60 × 1 s/frame, 30 s/frame) resolve rapid passage through vessels....
Purpose The kappa opioid receptor (KOR) plays a pivotal role in stress- and anxiety-related behaviors, with growing evidence linking it to stress induced by social isolation separation. Despite this, tools for studying KOR clinically relevant contexts remain limited. socially monogamous coppery titi monkey offers translational model investigating pair bonding. This study evaluated the feasibility of [ 11 C]GR103545 PET imaging characterize activity vivo , its pharmacological blockade first...
Traffic-related air pollution (TRAP) is a risk factor for Alzheimer disease (AD), where unresolved brain inflammation has been linked to deficits in the levels of free lipid mediators that enable resolution inflammation. It unknown whether these are due reductions esterified pools, main source bioactive pro-resolving lipids brain, and they related AD pathophysiology. This was tested by measuring pathogenic markers TgF344-AD wildtype (WT) male female rats exposed filtered or TRAP 14 months,...
The morphology of the hominoid distal femoral metaphyseal surface has been demonstrated to reflect locomotor behavior throughout ontogeny. Here, we quantify evaluate its predictive relationship behavioral modes in hominoids. We collected three-dimensional (3D) laser scans femora 177 human and great ape individuals representing all subadult stages development. used landmark-free Global Point Signature (GPS) method shape morphologically complex but amorphous surface. then analyzed GPS...
Molecular probes used for in vivo optical fluorescence tomography (OFT) studies small animals are typically chosen such that their emission spectra lie the 680–850 nm wavelength range. This is because tissue attenuation this spectral band relatively low, allowing photons even from deep sites to reach animal surface and consequently be detected by a CCD camera. The dependence of properties within can exploited emitted light measuring fluorescent data via multispectral approaches incorporating...
Background Carpal instability is defined as a condition where wrist motion and/or loading creates mechanical dysfunction, resulting in weakness, pain and decreased function. When conventional methods do not identify the patterns, yet clinical signs of exist, diagnosis dynamic often suggested to describe carpal derangement manifested only during wrist's active or stress. We addressed question: can advanced MRI techniques provide quantitative means evaluate supplement standard static...
Conventional whole-body static <sup>18</sup>F-FDG PET imaging provides a semiquantitative evaluation of overall glucose metabolism without insight into the specific transport and metabolic steps. Here we demonstrate ability total-body multiparametric to quantitatively evaluate using macroparametric quantification assess delivery phosphorylation processes microparametric for studying recovery from coronavirus disease 2019 (COVID-19). <b>Methods:</b> The study included 13 healthy subjects 12...
The primary purpose of this study was to demonstrate intraobserver/interobserver reproducibility for novel semiautomated measurements hepatic volume used Yttrium-90 dose calculations as well whole-liver and necrotic-liver (hypodense/nonenhancing) tumor after radioembolization. secondary aim provide initial comparisons volumetric with linear measurements, defined by Response Evaluation Criteria in Solid Tumors criteria, survival outcomes. Between 2006 2009, 23 consecutive radioembolization...