A5017284748- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Antibiotic Use and Resistance
- Enterobacteriaceae and Cronobacter Research
- SARS-CoV-2 detection and testing
- Tryptophan and brain disorders
- Single-cell and spatial transcriptomics
- Cancer, Hypoxia, and Metabolism
- Mosquito-borne diseases and control
- Colorectal Cancer Treatments and Studies
- HIV Research and Treatment
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Animal Virus Infections Studies
Tsinghua University
2020-2025
Beijing Tsinghua Chang Gung Hospital
2025
Center for Life Sciences
2020-2022
The pandemic of COVID-19, caused by SARS-CoV-2, is a major global health threat. Epidemiological studies suggest that bats (Rhinolophus affinis) are the natural zoonotic reservoir for SARS-CoV-2. However, host range SARS-CoV-2 and intermediate hosts facilitate its transmission to humans remain unknown. interaction coronavirus with receptor key genetic determinant cross-species transmission. uses angiotensin-converting enzyme 2 (ACE2) as enter cells in species-dependent manner. In this study,...
Hypervirulent Klebsiella pneumoniae(hvKp) is an increasingly important pathogen. Tracking its epidemiology and evolving antimicrobial resistance will facilitate care.
Abstract The pandemic of Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major global health threat. Epidemiological studies suggest that bats are the natural zoonotic reservoir for SARS-CoV-2. However, host range SARS-CoV-2 and intermediate hosts facilitate its transmission to humans remain unknown. interaction with receptor key genetic determinant cross-species transmission. uses angiotensin-converting enzyme (ACE2) as enter...
Abstract Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine. However, both regulation and biological functions asparagine in tumour cells remain largely unknown. Here, we report that p53 suppresses synthesis through transcriptional downregulation ASNS expression disrupts asparagine-aspartate homeostasis, leading lymphoma colon growth inhibition vivo vitro. Moreover, removal from culture medium or impairs cell proliferation induces p53/p21-dependent...
Abstract The efficacy of immunotherapy is largely patient-specific due to heterogeneity in tumors. Combining statistic power from a variety immunotherapies across cancer types, we found four biological pathways significantly correlated with patient survival following immunotherapy. expression prognostic marker genes (IPMGs) these can predict the high accuracy not only TCGA cohort (89.36%) but also two other independent cohorts (80.91%), highlighting that activity IPMGs reflect sensitivity...