A5053713996- Global Cancer Incidence and Screening
- Economic and Financial Impacts of Cancer
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Breast Cancer Treatment Studies
- Molecular Biology Techniques and Applications
- Autopsy Techniques and Outcomes
- Interpreting and Communication in Healthcare
- Tuberculosis Research and Epidemiology
- AI in cancer detection
- Cancer Genomics and Diagnostics
- Tumors and Oncological Cases
- BRCA gene mutations in cancer
- Bacterial Infections and Vaccines
- Data-Driven Disease Surveillance
- Pneumocystis jirovecii pneumonia detection and treatment
- Cleft Lip and Palate Research
- Neonatal Respiratory Health Research
- Bone health and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition, Genetics, and Disease
- Hepatocellular Carcinoma Treatment and Prognosis
Kenyatta National Hospital
2012-2023
Aga Khan University Nairobi
2019
Aga Khan University Hospital Nairobi
2019
Objective To evaluate medical resource utilisation and timeliness of access to specific aspects a standard care pathway for breast cancer at tertiary centres in sub-Saharan Africa. Design Data were retrospectively abstracted from records patients with treated within prespecified 2-year period between 2014 2017. The study protocol was approved by local institutional review boards. Setting Six institutions Ghana, Kenya Nigeria included. Participants Health 862 analysed: 299 Ghana; 314 Kenya;...
We compared minimally invasive tissue sampling (MITS) with conventional autopsy (CA) in detection of respiratory pathology/pathogens among Kenyan children younger than 5 years who were hospitalized disease and died during hospitalization.Pulmonary MITS guided by anatomic landmarks was followed CA. Lung tissues triaged for histology molecular testing using TaqMan Array Cards (TACs). CA results adequacy concordance.Adequate pulmonary obtained from 54 (84%) 64 deaths. Comparing to CA, full...
Fine-needle aspiration biopsy (FNAB) cytology is a simple, inexpensive, and accurate diagnostic test for benign, infectious, malignant lesions of the breast, thyroid, lymph nodes, other organs. Similarly, bone marrow trephine (BMAT) procedures are relatively simple inexpensive techniques that important diagnosing monitoring many hematologic diseases including leukemias lymphomas. However, scarcity pathologists in Kenya limits patient access to these tests. We describe task sharing shifting...
In sub-Saharan Africa, where the burden of respiratory disease-related deaths is highest, information on cause death remains inadequate because poor access to health care and limited availability diagnostic tools. Postmortem examination can aid in ascertainment causes death. This manuscript describes study protocol for Pediatric Respiratory Etiology Surveillance Study (PRESS).This aims identify etiologies associated with among children (age 1-59 months) illness admitted Kenyatta National...
6562 Background: Breast cancer is the most frequently diagnosed malignancy and common cause of cancer-related death in women Ghana, Kenya, Nigeria. We evaluated healthcare resource use financial burden for patients treated at tertiary centers these countries. Methods: Records breast following government/private were included – Ghana: Korle-Bu Teaching Hospital Sweden Ghana Medical Centre; Kenya: Kenyatta National Aga Khan University Hospital; Nigeria: Abuja Lakeshore Cancer Center. Patients...
Abstract Objectives To determine antibiotic susceptibility of community-acquired respiratory tract infection (CA-RTI) isolates Streptococcus pneumoniae and Haemophilus influenzae collected in 2015–18 from Tunisia, Kenya Morocco. Methods MICs were determined by CLSI broth microdilution was assessed using CLSI, EUCAST (dose-specific) pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results S. Tunisia (n = 79), 44) Morocco 19) H. 74) only analysed. Low observed with >90% susceptible...
e12546 Background: Breast cancer is the most common among women in Kenya. Kenyatta National Hospital (KNH) only public institution offering comprehensive care Methods: To determine pathology, clinical pattern and outcome of breast at KNH. Patients with histologically or cytologically confirmed cancer, able to provide written, informed consent, no prior interventional therapy were enrolled after approval by institutional regulatory board. Surgery, radiotherapy systemic applied line Kenyan...
Background: In resource-limited settings, acute respiratory infections continue to be the leading cause of death in young children. We conducted postmortem investigations children <5 years hospitalized with a clinical diagnosis disease at Kenya’s largest referral hospital. Methods: collected and other tissues examine pathologic processes using histology, molecular immunohistochemistry assays. Nasopharyngeal, trachea, bronchi lung specimens were tested 21-target pathogen real-time reverse...
Background Men of African ancestry experience higher burden from prostate cancer compared to men other ancestral backgrounds. Limitations in the availability high-quality biospecimens hinder inclusion this population genetic studies cancer. The use formalin-fixed paraffin-embedded (FFPE) tissues represent a potential rich source material particularly some international settings, where fresh frozen tissue is difficult obtain. In study, we investigate feasibility using FFPE acquired various...
139 Background: An analysis of 322 cases referred to Aga Khan University, Nairobi, revealed 56% estrogen receptor (ER) positive tumors and 35% prevalence triple-negative breast cancer (TNBC). Findings were retrospective limited by inability control pre-analytical variables that could potentially impact results. Methods: As part an ongoing prospective study assessing TNBC in the three major ethnic groups Kenya, we gathered a multidisciplinary team from 10 collaborating health facilities...
1117 Background: Breast cancer is the commonest type of among women worldwide, and number one cause deaths women. Its incidence increases with age, pathological subtype invasive ductal carcinoma. Hormone receptors (ER/PR) are expressed in about 70% cases associated favourable outcome. HERr2/Neu overexpressed 20-30% breast cancers aggressive disease poor outcomes. Tumours not expressing any these biological features (triple negative) commonly dire Reports so far indicate racial differences...
Abstract Prostate cancer (PCa) and breast (BCa) are leading causes of related deaths in American men women, morbidity is due to metastasis preferentially bone. Compared Caucasian (CA), African (AA) women have a higher bone density, as well mortality rate metastasis. Recent studies shown that high mobility group two (HMGA2), non-histone chromatin binding protein, plays critical role promoting epithelial-mesenchymal transition (EMT) HMGA2 full-length/wild-type truncated (without the 3’UTR)...
<sec> <title>BACKGROUND</title> In sub-Saharan Africa, where the burden of respiratory disease–related deaths is highest, information on cause death remains inadequate because poor access to health care and limited availability diagnostic tools. Postmortem examination can aid in ascertainment causes death. This manuscript describes study protocol for Pediatric Respiratory Etiology Surveillance Study (PRESS). </sec> <title>OBJECTIVE</title> aims identify etiologies associated with among...
Abstract Background: Men of African ancestry experience higher burden from prostate cancer compared to men other ancestral backgrounds. Limitations in the availability high-quality biospecimens have hindered inclusion this population genetic studies cancer. The use formalin-fixed paraffin-embedded (FFPE) tissues represents a potential rich source material particularly some international settings, where fresh frozen tissue is difficult obtain. Methods: A total 976 FFPE blocks were collected...
Retraction The abstract by Othieno-Abinya et al entitled, “Final report of Breast Cancer Care Registry at the Kenyatta National Hospital, Nairobi,” published in Journal Clinical Oncology 39, no. 15 suppl (May 20, 2021) e12552-e12552, was retracted authors as it did not meet study sponsor's prior scientific verification and approval. This on June 29, 2021. e12552 Background: cancer is commonest among women Kenya. We wanted to examine breast seen Hospital relation local factors that influence...