A5063214616- Emergency and Acute Care Studies
- Prostate Cancer Treatment and Research
- Trauma and Emergency Care Studies
- Cancer, Lipids, and Metabolism
- Testicular diseases and treatments
- Disaster Response and Management
- Pluripotent Stem Cells Research
- Healthcare Policy and Management
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Emergency Medicine Education and Research
- Clinical Reasoning and Diagnostic Skills
- Nursing Roles and Practices
- Patient Safety and Medication Errors
- Sperm and Testicular Function
- RNA modifications and cancer
- Sexual Differentiation and Disorders
- Innovations in Medical Education
- Simulation-Based Education in Healthcare
- Estrogen and related hormone effects
- Medical Malpractice and Liability Issues
- Hormonal and reproductive studies
- Hospital Admissions and Outcomes
- Healthcare Operations and Scheduling Optimization
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
Salisbury University
2014-2025
Harvard University
2005-2020
Brigham and Women's Hospital
2010-2020
Beth Israel Deaconess Medical Center
2005-2017
Liverpool Hope University
2016
Hadassah Medical Center
2007-2016
Vanderbilt University Medical Center
2011-2013
University of Maryland, College Park
2011-2012
Vanderbilt University
2012
Harvard University Press
2008-2011
Androgen receptor (AR) action throughout prostate development and in maintenance of the prostatic epithelium is partly controlled by interactions between AR forkhead box (FOX) transcription factors, particularly FOXA1. We sought to identity additional FOXA1 binding partners that may mediate prostate-specific gene expression. Here we identify nuclear factor I (NFI) family factors as novel proteins. All four members (NFIA, NFIB, NFIC, NFIX) can interact with FOXA1, knockdown studies...
Cooperativity between oncogenic mutations is recognized as a fundamental feature of malignant transformation, and it may be mediated by synergistic regulation the expression pro- antitumorigenic target genes. However, mechanisms which oncogenes tumor suppressors coregulate downstream targets pathways remain largely unknown. Here, we used ChIP coupled to massively parallel sequencing (ChIP-seq) gene profiling in mouse prostates identify direct suppressor Nkx3.1. Further analysis indicated...
The goal of this study was to identify publications in the medical literature that support efficacy or value Emergency Medicine (EM) as a specialty and clinical care delivered by trained emergency physicians. In we use term "value" refer both "efficacy care" terms achieving desired patient outcomes, well "efficiency" effective and/or cost-effective utilization healthcare resources delivering care. A comprehensive listing describing EM has not been previously published. It is anticipated...
Accurate and comprehensive healthcare data coupled with modern analytical tools can play a vital role in enabling care providers to make better-informed decisions, leading effective cost-eff ...
Emergency medicine (EM) is a global discipline that provides secondary disease prevention and also tool for primary prevention. It horizontally integrated system of emergency care consisting access to EM care; provision in the community during transportation patients; at receiving facility or hospital department. can offer many tools improve public health. These include prevention; interventions addressing substance abuse interpersonal violence; education about safety practices;...
An instrument was developed to study the use of hospital beds and discharge arrangements a cohort 847 admissions John Radcliffe Hospital, Oxford, for three week period during February-March 1986. For only 38% bed days were patients considered have medical, nursing, or life support reasons requiring provincial teaching bed. The requirements in decreased with patient's age length stay hospital. tenth general practitioner concerned discussions staff about less than one third had been given more...
A functional complex consisting of androgen receptor (AR) and forkhead box A1 (FOXA1) proteins supports prostatic development, differentiation, disease. In addition, the interaction FOXA1 with cofactors such as nuclear factor I (NFI) family members modulates AR target gene expression. However, global role specific NFI has yet to be described in prostate. these studies, chromatin immunoprecipitation followed by DNA sequencing androgen-dependent LNCaP prostate cancer cells demonstrated that...
The objective was to describe the common educational goals, curricular elements, and methods of evaluation used in international emergency medicine (IEM) fellowship training programs currently. IEM have been developed provide formal for physicians (EPs) interested pursuing careers IEM. Those fellowships are variable scope, objectives, duration. Previously published articles suggested a general curriculum structure fellowships.A search MEDLINE, EMBASE, CINAHL databases from 1950 June 2008...
The homeodomain-containing transcription factor, NKX3.1, plays an important role in the suppression of prostate tumorigenesis.Herein, we identify receptor activityemodifying protein 1 (RAMP1) as a direct NKX3.1 target gene through analysis chromatin immunoprecipitation coupled to massively parallel sequencing and expression data.RAMP1 is coreceptor for certain G-proteinecoupled receptors, such calcitonin gene-related peptide receptor, plasma membrane.We found that RAMP1 specifically elevated...
Castration-resistant prostate cancer can be treated with the antiandrogen enzalutamide, but responses and duration of response are variable. To identify genes that support enzalutamide resistance, we performed a short hairpin RNA (shRNA) screen in bone-homing, castration-resistant cell line, C4-2B. We identified 11 (TFAP2C, CAD, SPDEF, EIF6, GABRG2, CDC37, PSMD12, COL5A2, AR, MAP3K11, ACAT1) whose loss resulted decreased survival to enzalutamide. validate our screen, transient knockdowns...
Objective To evaluate medical resource utilisation and timeliness of access to specific aspects a standard care pathway for breast cancer at tertiary centres in sub-Saharan Africa. Design Data were retrospectively abstracted from records patients with treated within prespecified 2-year period between 2014 2017. The study protocol was approved by local institutional review boards. Setting Six institutions Ghana, Kenya Nigeria included. Participants Health 862 analysed: 299 Ghana; 314 Kenya;...
Despite strong heritability, little is known about the genetic control of susceptibility to testicular germ cell tumors (TGCT) in humans or mice. Although mouse model spontaneous TGCTs has been extensively studied, conventional linkage analysis failed locate factors that teratocarcinogenesis susceptible 129 family inbred strains. As an alternative approach, we used both chromosome substitution strains (CSS) identify individual chromosomes harbor genes and a panel congenic derived from...
Discordant results in preclinical and clinical trials have raised questions over the effectiveness of antioxidants prostate cancer chemoprevention. Results from large-scale Selenium Vitamin E Cancer Prevention Trial (SELECT) showed that failed to prevent, some cases promoted, formation men without a history disease. One possible explanation for these alarming is notion effects antioxidant treatment on are modified by specific, intrinsic genetic risk factors, causing respond negatively...
The aim of this work was to train machine learning models identify patients at end life with clinically meaningful diagnostic accuracy, using 30-day mortality in discharged from the emergency department (ED) as a proxy.Retrospective, population-based registry study.Swedish health services.All cause mortality.Electronic records (EHRs) and administrative data were used six supervised predict all-cause within 30 days EDs southern Sweden, Europe.The trained 65 776 ED visits validated on 55 164...
Abstract Aims Patients with heart failure (HF) have high costs, morbidity, and mortality, but it is not known if appropriate pharmacotherapy (AP), defined as compliance international evidence-based guidelines, associated improved costs outcomes. The purpose of this study was to evaluate HF patients’ health care utilization, cost outcomes in Region Halland (RH), Sweden, AP lower costs. Methods results A total 5987 residents RH 2016 carried diagnoses. Costs were assigned all utilization...
Abstract Due to supply chain disruption, the COVID-19 pandemic has caused severe shortages in personal protective equipment (PPE) for health care professionals. Local fabrication based on 3D printing is one way address this challenge, particularly case of simple products such as face shields. As a consequence, many public domain designs shields have become available. No clear path exists, however, introducing locally fabricated and unapproved product into clinical setting. In US setting, are...