A5003967548- Pharmacogenetics and Drug Metabolism
- Eicosanoids and Hypertension Pharmacology
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Complementary and Alternative Medicine Studies
- Inflammatory mediators and NSAID effects
- Drug-Induced Hepatotoxicity and Protection
- Retinoids in leukemia and cellular processes
- Alcohol Consumption and Health Effects
- Hormonal and reproductive studies
- Cancer Treatment and Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Natural product bioactivities and synthesis
- Glutathione Transferases and Polymorphisms
- Metabolism and Genetic Disorders
- Analytical Chemistry and Chromatography
- Oral Health Pathology and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Plant Pathogens and Fungal Diseases
- Acne and Rosacea Treatments and Effects
The University of Sydney
2015-2024
Woolcock Institute of Medical Research
2024
Macquarie University
2009-2024
VA Office of Research and Development
2024
Sydney Local Health District
2024
VA Boston Healthcare System
2022-2024
Genomic Health (United States)
2022
Australasian Leukaemia and Lymphoma Group
2020
Carolina Ear, Nose and Throat Clinic
2009-2020
Japanese Foundation For Cancer Research
2018
To determine whether cytochrome P450 proteins were differentially altered in severe chronic liver diseases, we examined 50 livers removed at transplantation from patients with end-stage cirrhosis, including 18 and 32 without cholestasis, compared the results 21 histologically normal livers. NADPH-cytochrome c reductase activities unaltered microsomes cirrhotic Total content was significantly reduced. The catalytic of four xenobiotic-metabolizing P450s level corresponding altered. Thus,...
Storage of maternal mRNAs as nontranslated ribonucleoprotein (RNP) complexes is an adaptive strategy in various vertebrate and invertebrate oocytes, for rapid translational recruitment during embryonic development. Previously, we showed that Xenopus laevis oocytes have a soluble cytoplasmic pool mRNA-binding proteins particles competent messenger RNP assembly vitro. Here report the isolation cDNAs most abundant RNPs, 54- 56-kDa polypeptide (p54/p56) components approximately 6S particle, from...
Abstract Background Hepatocellular carcinoma (HCC) remains a leading life-threatening health challenge worldwide, with pressing needs for novel therapeutic strategies. Sphingosine kinase 1 (SphK1), well-established pro-cancer enzyme, is aberrantly overexpressed in multitude of malignancies, including HCC. Our previous research has shown that genetic ablation Sphk1 mitigates HCC progression mice. Therefore, the development PF-543, highly selective SphK1 inhibitor, opens new avenue treatment....
Ferritin stores iron within a protein shell consisting of 24 subunits two types, heavy (H) and light (L). According to Southern blotting, the rat genome contains four copies homologous H-subunit cDNA (H cDNA). To determine whether only one these is expressed, H cDNAs isolated from liver heart mRNAs were compared found share identical nucleotide sequences. Next, genomic clones for three loci isolated. Two classical processed pseudogenes, whereas third contained an expressed gene. RNase intron...
Studies in rat liver have shown that cytochrome P450 (CYP) enzymes mediate the oxidative biotransformation of phosphorothioate pesticide parathion to paraoxon and 4-nitrophenol. Transfer thionosulfur atom CYP apoprotein results amino acid modification enzyme inactivation. Our study investigated role human hepatic oxidation their relative susceptibilities inhibition Rates varied about 10-fold microsomes from 23 individual livers (1.72-18.33 nmol total metabolites/mg protein/min). Linear...
To gain insight into the mechanisms involved in formation of maternally stored mRNPs during Xenopus laevis development, we searched for soluble cytoplasmic proteins oocyte that are able to selectively bind mRNAs, using as substrate radiolabeled mRNA. In vitro mRNP assembly solution was followed by UV-cross-linking and RNase digestion, resulting covalent tagging polypeptides nucleotide transfer. Five approximately 54, 56 60, 70, 100 kD (p54, p56, p60, p70, p100) have been found mRNA assemble...
Patients commonly take complementary medicines in conjunction with conventional drugs without clear evidence of safety or the risk herb-drug interactions. The aim this study was to assess potential pharmacokinetic (PK) and pharmacodynamic (PD) interactions between St John's wort gliclazide healthy subjects different cytochrome P450 2C9 (CYP2C9) genotypes.
BACKGROUND AND PURPOSE Imatinib is a clinically important inhibitor of tyrosine kinases that are dysregulated in chronic myelogenous leukaemia and gastrointestinal stromal tumours. Inter‐individual variation imatinib pharmacokinetics extensive, influences drug safety efficacy. Hepatic cytochrome P450 (CYP) 3A4 has been implicated N‐demethylation, but the clearance decreases during prolonged therapy. CYP3A phenotype correlates with at commencement therapy, not steady state. The present study...