A5103099765- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Retinoids in leukemia and cellular processes
- Advanced Nanomaterials in Catalysis
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Sirtuins and Resveratrol in Medicine
- Antioxidant Activity and Oxidative Stress
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Advanced Drug Delivery Systems
- Autophagy in Disease and Therapy
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- interferon and immune responses
- Calcium signaling and nucleotide metabolism
- Retinal and Optic Conditions
- Lipid Membrane Structure and Behavior
Centro de Investigacion Principe Felipe
2020-2025
Instituto de Investigación Sanitaria La Fe
2021-2025
Instituto de Salud Carlos III
2024
Instituto de Investigación de Enfermedades Raras
2024
Spanish National Cancer Research Centre
2008
Retinitis pigmentosa (RP) is a group of inherited retinal dystrophies characterized by the progressive and irreversible loss vision. We previously found that intraperitoneal administration Adalimumab, monoclonal anti-TNFα antibody, slowed down degeneration in murine model RP, rd10 mice. The aims this study were to improve its neuroprotective effect deepen understanding molecular mechanisms involved effect. analyzed (i) vitro Adalimumab on TNFα-mediated cell death cells; (ii) single...
Retinitis pigmentosa (RP) is a group of inherited retinal dystrophies characterized by progressive degeneration photoreceptor cells. Ocular redox status altered in RP suggesting oxidative stress could contribute to their progression. In this study, we investigated the effect mixture nutraceuticals with antioxidant properties (NUT) on rd10 mice, model RP. NUT was orally administered mice from postnatal day (PD) 9 PD18. At PD18 function and morphology were examined electroretinography (ERG)...
Abstract Background Retinitis pigmentosa is the prevailing genetic cause of blindness in developed nations with no effective treatments. In pursuit unraveling intricate dynamics underlying this complex disease, mechanistic models emerge as a tool proven efficiency rooted systems biology, to elucidate interplay between RP genes and their mechanisms. The integration drug-target interactions under umbrella machine learning methodologies provides multifaceted approach that can boost discovery...
Retinitis pigmentosa (RP) is the most common inherited retinal dystrophy causing progressive vision loss. It accompanied by chronic and sustained inflammation, including M1 microglia activation. This study evaluated effect of an essential fatty acid (EFA) supplement containing specialized pro-resolving mediators (SPMs), on degeneration activation in rd10 mice, a model RP, as well LPS-stimulated BV2 cells. The EFA was orally administered to mice from postnatal day (P)9 P18. At P18, electrical...
Oxidative stress plays a major role in the pathogenesis of retinitis pigmentosa (RP). The main goal this study was to evaluate effect 2-year nutritional intervention with antioxidant nutraceuticals on visual function RP patients. Secondly, we assessed how affected ocular and systemic redox status. We carried out randomized, double-blind, placebo-controlled study. Thirty-one patients participated randomly received either mixture (NUT) containing folic acid, vitamin B6, A, zinc, copper,...
Inherited retinal dystrophies (IRDs) constitute a heterogeneous group of diseases that cause the progressive loss vision. They are mainly associated with photoreceptor (rods and cones) or pigment epithelium (RPE) dysfunction loss. Several therapeutic strategies ongoing in animal models patients, including gene, cell, pharmacological therapies. However, at present, there is only one effective treatment available, Luxturna. The eye presents some characteristics facilitate development different...
*Correspondence: rrodrigo@cipf.es; Tel: (+34 96 328 80) Retinitis pigmentosa (RP) is the most common inherited retinal dystrophy causing progressive vision loss. Ocular redox status altered in RP suggesting oxidative stress could contribute to their progression. In addition, it accompanied by chronic and sustained inflammation, including M1 microglia activation. our group we evaluated, both effect of a mixture nutraceuticals with antioxidant properties (NUT) an essential fatty acid (EFA)...
Abstract Background Retinitis pigmentosa is the prevailing genetic cause of blindness in developed nations with no effective treatments. In pursuit unraveling intricate dynamics underlying this complex disease, mechanistic models emerge as a tool proven efficiency rooted systems biology, to elucidate interplay between RP genes and their mechanisms. The integration drug-target interactions under umbrella machine learning methodologies provides multifaceted approach that can boost discovery...