A5021905069- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- COVID-19 diagnosis using AI
- Cardiomyopathy and Myosin Studies
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Advanced X-ray and CT Imaging
- SARS-CoV-2 and COVID-19 Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Respiratory viral infections research
- Glioma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Glaucoma and retinal disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Coronary Artery Anomalies
- Software Testing and Debugging Techniques
- Air Quality and Health Impacts
- Cardiac Health and Mental Health
Sichuan University
2014-2025
Xiamen University
2025
Zhejiang Province Institute of Architectural Design and Research
2025
Zhejiang University
2012-2025
Guangzhou University of Chinese Medicine
2025
Northwest Normal University
2024
China Tourism Academy
2024
West China Hospital of Sichuan University
2019-2024
Zhongda Hospital Southeast University
2020-2023
Guangdong Province Women and Children Hospital
2022-2023
Background: The coronavirus disease 2019 (COVID-19) has become a global challenge since the December 2019. hospital stay is one of prognostic indicators, and its predicting model based on CT radiomics features important for assessing patients' clinical outcome. study aimed to develop test machine learning-based models in patients with COVID-19 pneumonia. Methods: This retrospective, multicenter enrolled laboratory-confirmed SARS-CoV-2 infection their initial images from 5 designated...
Accumulating evidence has demonstrated that up-regulation of the angiotensin (Ang)-converting enzyme (ACE)/AngII/AngII type 1 receptor (AT1R) axis aggravates pulmonary fibrosis. The recently discovered ACE2/Ang-(1-7)/Mas axis, which counteracts activity ACE/AngII/AT1R been shown to protect against However, mechanisms by ACE2 and Ang-(1-7) attenuate fibrosis remain unclear. We hypothesized protects bleomycin (BLM)-induced inhibiting mitogen-activated protein kinase (MAPK)/NF-κB pathway. In...
Abstract Objectives To develop and test machine learning-based CT radiomics models for predicting hospital stay in patients with pneumonia associated SARS-CoV-2 infection. Design Cross-sectional Setting Multicenter Participants A total of 52 laboratory-confirmed infection their initial images were enrolled from 5 designated hospitals Ankang, Lishui, Zhenjiang, Lanzhou, Linxia between January 23, 2020 February 8, 2020. As 20, remained or non-findings excluded. Therefore, 31 72 lesion segments...
Rationale: Chest computed tomography (CT) has been used for the coronavirus disease 2019 (COVID-19) monitoring. However, imaging risk factors poor clinical outcomes remain unclear. In this study, we aimed to assess characteristics and associated with adverse composite endpoints in patients COVID-19 pneumonia. Methods: This retrospective cohort study enrolled laboratory-confirmed from 24 designated hospitals Jiangsu province, China, between 10 January 18 February 2020. Clinical initial CT...
Angiotensin II (AngII), a vasoconstrictive peptide of the renin-angiotensin system (RAS), promotes hepatic fibrogenesis and induces microRNA-21(mir-21) expression. Angiotensin-(1-7) [Ang-(1-7)] is RAS, which attenuates liver fibrosis. Recently, it was reported that NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome participated in However, remains unclear how mir-21 mediates AngII-induced NLRP3 activation. We investigate role regulation inflammasome/IL-1β axis...
To determine the patterns of chest computed tomography (CT) evolution according to disease severity in a large coronavirus 2019 (COVID-19) cohort Jiangsu Province, China.This retrospective study was conducted from January 10, 2020, February 18, 2020. All patients diagnosed with COVID-19 Province were included, retrospectively. Quantitative CT measurements pulmonary opacities including volume, density, and location extracted by deep learning algorithm. Dynamic these investigated symptom onset...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mimics the influenza A (H1N1) virus in terms of clinical presentation, transmission mechanism, and seasonal coincidence. Comprehensive data for severity adult patients co-infected by both H1N1 SARS-CoV-2, and, particularly, relationship with PCR cycle threshold (Ct) values are not yet available. All participants this study were tested SARS-CoV-2 simultaneously at admission. Demographic, clinical, treatment, laboratory extracted...
This study set out to develop a computed tomography (CT)-based wavelet transforming radiomics approach for grading pulmonary lesions caused by COVID-19 and validate it using real-world data.This retrospective analyzed 111 patients with 187 from 16 hospitals; all had confirmed underwent non-contrast chest CT. Data were divided into training cohort (72 127 nine hospitals) an independent test (39 60 seven according the hospital in which CT was performed. In all, 73 texture features extracted...
Colorectal cancer (CRC) is a major cause of cancer-related death worldwide. The poor prognosis CRC mainly due to uncontrolled tumor growth and distant metastases. In this study, we found that the level FGF8 was elevated in great majority cases high expression significantly correlated with lymph nodes metastasis worse overall survival. Functional studies showed can induce more aggressive phenotype displaying epithelial-to-mesenchymal transition (EMT) enhanced invasion cells. Consistent this,...
Maternal sepsis results in poor outcomes such as fetal or maternal death. The incidence and mortality rates of vary different places because differences economic development, race medical conditions. Identifying the clinical features determining possible mechanisms for avoiding morbidity preventing would benefit committed patients. Therefore, this was an epidemiological study at a maternity transfer center Southeast China that aimed to identify local disease sepsis. To investigate risk...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic that has currently infected over 430 million individuals worldwide. With the variant strains of SARS-CoV-2 emerging, region high mutation rates in ORF8 was identified during early pandemic, which resulted from leucine (L) to serine (S) at amino acid 84. A typical feature immune evasion suppressing interferon response; however, mechanisms two variants antagonize...
Abstract The aim of this study was to investigate left ventricular (LV) global myocardial strain and LV involvement characteristics in patients with arrhythmogenic right dysplasia/cardiomyopathy (ARVD/C) evaluate their predictive value adverse cardiac events. Sixty consecutive ARVD/C a definite diagnosis who underwent CMR examination thirty-four healthy controls were enrolled retrospectively. images analyzed for the presence involvement. endpoint defined as composite sustained tachycardia or...
Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome sex-specific pathophysiology. Estrogen deficiency believed to be responsible for the development of HFpEF in women. However, estrogen does not seem completely differences prevalence between sexes. While diabetes mellitus (DM) frequently coexists women and associated worse outcomes, changes myocardial contractility among DM phenotype yet unknown. Therefore, we aimed investigate sex-related...
Coronary artery disease (CAD) confers considerable morbidity and mortality in diabetes. However, the role of CAD additive effect left ventricular (LV) function has rarely been explored type 2 diabetes mellitus (T2DM) patients. This study aimed to investigate how affect LV systolic diastolic T2DM patients.A total 282 patients {104 with [T2DM (CAD +)] 178 without -)]} 83 sex- age- matched healthy controls underwent cardiac magnetic resonance scanning. structure, function, global strains...
Backgrounds Frailty is a significant problem for older persons since it linked to number of unfavorable consequences. According observational researches, air pollution may raise the risk frailty. We investigated causal association between frailty and (including PM 2.5 , 2.5–10 10 nitrogen dioxide, oxides) using Mendelian randomization approach. Methods conducted MR analysis extensive publically accessible GWAS (genome-wide studies) summary data. The inverse variance weighted (IVW) method was...