A5011891686- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Barrier Structure and Function Studies
- Circadian rhythm and melatonin
- Nanoplatforms for cancer theranostics
- Glioma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
University of Manitoba
2022-2025
Abstract Brain metastasis occurs in about 50% of all women with metastatic HER2+ breast cancer and confers poor prognosis for patients. Despite effective HER2-targeted treatments peripheral trastuzumab HER2 inhibitors, limited brain permeability renders these inefficient (BCBM). The scarcity suitable patient-derived vivo models BCBM has curtailed the study molecular mechanisms that promote growth therapeutic resistance metastasis. Here, we generated characterized a luminal B cell model...
<p>Effect of ErbB inhibitors on cell viability in BCBM94 and HME-1 cells</p>
<p>Comparison ErbB inhibitor response in BCBM94 and NGN2 neurons</p>
<p>ErbB inhibitor response in the presence of rhNRG1</p>
<p>Supplemental figures and legends</p>
<div>Abstract<p>Brain metastasis occurs in about 50% of all women with metastatic HER2<sup>+</sup> breast cancer and confers poor prognosis for patients. Despite effective HER2-targeted treatments peripheral trastuzumab HER2 inhibitors, limited brain permeability renders these inefficient metastasis. The scarcity suitable patient-derived <i>in vivo</i> models has curtailed the study molecular mechanisms that promote growth therapeutic resistance In this...
ABSTRACT Brain metastasis of HER2+ breast cancer occurs in about 50% all women with metastatic and confers poor prognosis for patients. Despite effective HER2-targeted treatments peripheral Trastuzumab +/-HER2 inhibitors, limited brain permeability renders these inefficient (BCBM). The scarcity suitable patient-derived in-vivo models BCBM has compromised the study molecular mechanisms that promote growth therapeutic resistance metastasis. We have generated characterized new cells (BCBM94)...
The study was carried out with the aim to evaluate effects of continuous lightning (CL) and subsequent circadian rhythm disruption on CD4+/CD8+ populations adaptive cell immunity. For further understanding underlying processes that affect proliferation differentiation, expression levels CD3+ CD95+ receptors were evaluated. Chinchilla rabbits exposed shift work simulation - 24 hours CL. We organized 5 time-related groups: 2, 4, 6, 12 months CL respectively. 5th group – corresponding control....