A5051042923- Judicial and Constitutional Studies
- Legal and Constitutional Studies
- Ovarian function and disorders
- American Constitutional Law and Politics
- Hypothalamic control of reproductive hormones
- Space exploration and regulation
- Reproductive System and Pregnancy
- Legal Systems and Judicial Processes
- Space Exploration and Technology
- Estrogen and related hormone effects
- Reproductive Biology and Fertility
- Spaceflight effects on biology
- Advanced MRI Techniques and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced NMR Techniques and Applications
- Music History and Culture
- Language, Metaphor, and Cognition
- Endometriosis Research and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Planetary Science and Exploration
- Chemical Synthesis and Analysis
- Spacecraft Design and Technology
- Stress Responses and Cortisol
- NMR spectroscopy and applications
Los Alamos National Laboratory
2007-2024
Rutgers Sexual and Reproductive Health and Rights
1987-2023
University of Vermont
2011-2020
Lawrence University
2004-2019
University of Arts in Belgrade
2019
University of California, San Diego
2004-2019
University of Sarajevo
2019
University of Louisville
2019
University of Vermont Medical Center
1985-2015
DePaul University
2015
Objective To determine the factors associated with false-negative results on sentinel node biopsy and localization (identification rate) in patients breast cancer enrolled a multicenter trial using combination technique of isosulfan blue technetium sulfur colloid (Tc99). Summary Background Data Sentinel is diagnostic test used to detect metastases. reliability this method, complete lymph dissection must be performed rate. Single-institution series have reported excellent results, although...
A novel method for extracting butyrylcholinesterase (BuChE) from serum as a means of identifying and measuring nerve agent adducts to human BuChE is presented here. Antibutyrylcholinesterase monoclonal antibodies were conjugated protein-G ferromagnetic particles mixed with 500 μL samples. The particle-antibody-BuChE product was rinsed directly digested pepsin. Native isotopically enriched nonapeptides corresponding the pepsin digest products uninhibited BuChE, sarin, cyclohexylsarin, VX,...
A new antiinflammatory agent identified as 8-[C-β-d-[2-O-(E)-cinnamoyl]glucopyranosyl]-2-[(R)-2-hydroxypropyl]-7-methoxy-5-methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 μg/mouse ear, 1 exhibited topical activity equivlaent to μg/ear hydrocortisone. There was no reduction in thymus weight caused by treatment with for any the doses tested, while hydrocortisone resulted 50% decrease weight.
We investigated hormonal regulation of endometrial angiogenesis in menstruating primates. This study was designed to demonstrate: (i) that cell-specific vascular endothelial growth factor (VEGF) production and expression monkey endometrium are regulated by steroid receptor ligands; (ii) mifepristone (RU 486) alters VEGF even the absence a progestin agonist. Endometrial compared computer-assisted immunohistochemical analysis during induced hypoestrogenism after oestradiol, progestin, or...
In the follicular phase of menstrual cycle, pulsatile patterns LH and FSH secretion in monkeys change during maturation dominant follicle. At preovulatory surge, most striking event is prodigious elevations bioassayable LH, rising up to 50-fold within 24 h. Principally, establishment surge due marked enhancement amplitude secretory pulses. contrast, measured by RIA enter, parallel, modes approximately 5 h later than rise more slowly; B:I ratio may reach 10:1. This same disparity between...
Calcitonin inhibits both osteoclast formation and bone resorption, is a primary treatment for patients with hypercalcemia increased turnover. However, the clinical utility of calcitonin limited because become refractory to after several days (the "escape phenomenon"). The molecular basis "escape" unclear. To determine regulatory mechanisms controlling receptor (CTR) expression in osteoclasts their precursors, we treated immature mononuclear precursors human osteoclast-like multinucleated...
RU 486 is a synthetic steroid with anti-progesterone and anti-glucocorticoid properties. While studying its acute effects on pituitary hormone secretion in cynomolgus monkeys, we found that inhibited PRL induced by an estrogen-progesterone synergy (P less than 0.025). By contrast, plasma levels of ACTH, arginine vasopressin cortisol increased following administration 0.05). Plasma FSH, LH, GH TSH were unaffected treatment. Our findings suggest potential diagnostic therapeutic applications 486.
The phycobilisomes of the unicellular cyanobacterium Synechocystis 6701, grown in white light, contain C-phycoerythrin, C-phycocyanin, and allophycocyanin a molar ration approximately 2:2:1, addition, polypeptides 99, 46, 33.5, 31.5, 30.5, 27 x 10(3) Daltons, as well trace 9 10(3)-dalton component. Two nitrosoguanidine-induced mutants this organism produce aberrant phycobilisomes. Crude cell extracts these mutants, 6701-NTG25 NTG31, phycoerythrin, phycocyanin, 1:5:1:1 0.55:0.3:1.0,...
The development of efficient catalysts and processes for synthesizing functionalized (olefinic and/or chiral) primary alcohols fluoral hemiacetals is currently needed. These are valuable building blocks pharmaceuticals, agrochemicals, perfumes, so forth. From an economic standpoint, bench-stable Takasago Int. Corp.’s Ru-PNP, more commonly known as Ru-MACHO, Gusev’s Ru-SNS complexes arguably the most appealing molecular to access from esters H2 (Waser, M. et al. Org. Proc. Res. Dev. 2018, 22,...
Serum immunoreactive insulin (IRI) levels were higher in older persons initially and throughout a three-hour glucose tolerance test when 176 from random sample of Sudbury, Massachusetts tested. Multiple regression analyses indicate that the IRI are associated with rise blood body weight accompanied advancing age. Consequently, different frequency distributions interdependent variables various studies probably explain contradictory results literature changes age interpreted. It is concluded...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Free Hydroxyl ContentCarl J. Malm, Leo B. Genung, and Robert F. Williams, Jr.Cite this: Ind. Eng. Chem. Anal. Ed. 1942, 14, 12, 935–940Publication Date (Print):December 1, 1942Publication History Published online1 May 2002Published inissue 1 December 1942https://pubs.acs.org/doi/10.1021/i560112a007https://doi.org/10.1021/i560112a007research-articleACS PublicationsRequest reuse permissionsArticle Views483Altmetric-Citations13LEARN...
Nitric oxide synthase (NOS) catalyzes sequential NADPH- and O2-dependent mono-oxygenase reactions converting L-arginine to Nω-hydroxy-L-arginine citrulline nitric oxide. The homodimeric enzyme contains one heme/monomer, that cofactor is thought mediate both partial reactions. Here we show by electron paramagnetic resonance spectroscopy binding of substrate neuronal NOS perturbs the heme pocket without directly interacting as a sixth axial ligand; iron exclusively high spin. In contrast,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalysis of Cellulose Derivatives Total Acyl in Organic Esters by Saponification SolutionCarl J. Malm, Leo B. Genung, Robert F. Williams, Jr., and Mary Alice. PileCite this: Ind. Eng. Chem. Anal. Ed. 1944, 16, 8, 501–504Publication Date (Print):August 19, 1944Publication History Published online1 May 2002Published inissue 19 August 1944https://pubs.acs.org/doi/10.1021/i560132a007https://doi.org/10.1021/i560132a007research-articleACS...
The fact that RU 486 curtailed estrogen-induced endometrial proliferation in primates and relieved pelvic pain women with endometriosis is the reason for continuing research on antiprogestins. Thirty-two adult female cynomolgus monkeys demonstrating menstrual regularity had surgery induction of endometriosis. After lesion staging, four treatment groups (n = 8), each 1-yr duration, were made. Group I received combination/sequential therapy depot GnRH agonist (GnRH-a) 3 months, followed by...