A5031614373- Dysphagia Assessment and Management
- Bone Tissue Engineering Materials
- Titanium Alloys Microstructure and Properties
- Orthopaedic implants and arthroplasty
- Bone and Dental Protein Studies
- Tracheal and airway disorders
- Dental Implant Techniques and Outcomes
- Voice and Speech Disorders
- Bone health and treatments
- Protease and Inhibitor Mechanisms
- Functional Brain Connectivity Studies
- Child Nutrition and Feeding Issues
- Dental Health and Care Utilization
- Drug Transport and Resistance Mechanisms
- Gastroesophageal reflux and treatments
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Social Robot Interaction and HRI
- 14-3-3 protein interactions
- Metal and Thin Film Mechanics
- Drug-Induced Ocular Toxicity
- Simulation-Based Education in Healthcare
- Hydrogen's biological and therapeutic effects
- Neutropenia and Cancer Infections
- Oral and gingival health research
Tohoku University
2009-2024
Japan Society for the Promotion of Science
2023
Iwate Medical University
2023
Tohoku University Hospital
2022
Niigata University
2017-2021
Kikkoman (Japan)
2019
University of Chicago
2017
Tohoku Medical Megabank Organization
2015
Kumamoto University
2006
Oita University
1998-2000
Matrix metalloproteinases (MMP), such as 72 kDa type IV collagenase (MMP-2) and 92 (MMP-9), play an important role in tumor invasion metastasis. Tissue inhibitors of (TIMP-1 TIMP-2) are specific MMP. To evaluate the expression TIMP-1, TIMP-2, MMP-2, MMP-9 human colorectal cancer, surgical specimens primary cancer (66 cases) liver metastases (10 were examined by Northern dot-blot hybridization. The levels MMP-2 mRNA significantly higher cancers than their adjacent normal tissues, those mRNAs...
Dental implants are widely used and a predictable treatment in various edentulous cases. Occlusal overload may be causally related to implant bone loss of integration. Stress concentrations diminished using mechanobiologically integrated with tissue. The purpose this study was investigate the biomechanical behavior, biocompatibility bioactivity Ti-Nb-Sn alloy as dental material. It compared cpTi. Cell proliferation alkaline phosphatase (ALP) activity were quantified. To assess degree...
Swallowing pressure generation is important to ensure safe transport of an ingested bolus without aspiration or leaving residue in the pharynx. To clarify mechanism, we measured swallowing at oropharynx (OP), upper esophageal sphincter (UES), and cervical esophagus (CE) using a specially designed manometric catheter anesthetized rats. A swallow, evoked by punctate mechanical stimulation larynx, was identified recording activation suprahyoid thyrohyoid muscles electromyography (EMG). Areas...
Afferents carried by the superior laryngeal nerve play a primary role in initiation of mechanically evoked swallows anaesthetized rats. Amiloride and its analogues inhibit swallowing mechanical stimulation, but not chemical electrical stimulation. The epithelial sodium channel is probably involved swallows.The reflex plays critical airway protection. Because impaired mechanosensation associated with food bolus aspiration, it important to know how sensory system regulates initiation. This...
The objective of the present study was to evaluate effectiveness introducing integrated jaw models, rubric criteria and homework tasks a total clinical simulation training course improve competence preclinical dental students.A course, which involved six dentistry departments, held for 110 students in 2014 2015. We prepared models having several morbidities along with corresponding medical information tasks. formulated diagnoses devised treatment plans before performing on mannequin under...
Calcium Titanate (CaTiO3) has been introduced as an attractive biomaterial for the enhancement of calcium phosphate deposition in vivo and vitro. We hypothesized that CaTiO3 directly coated on titanium (Ti) by metal-organic chemical vapor (MOCVD) could be a suitable candidate biocompatible coatings medical devices, particularly dental implants. To prove this hypothesis, surface characterization, cell culture, animal study were completed study. The result showed CTO 800, film prepared heating...
Ti–29Nb–13Ta–4.6Zr alloy (TNTZ), a new β-type Ti alloy, has excellent advantages as biomaterial, such low Young's modulus and cytotoxicity, the absence of allergens. However, it is unclear whether TNTZ can achieve sufficient osseointegration for to be used dental implant. The effectiveness surface modification implants by radiofrequency (RF) magnetron sputtering also unclear. We investigated biomechanical behaviors in vivo, using cylindrical four types: pure Ti, TNTZ, coated with amorphous...
Many β-Ti alloys have been developed for, and used in, medical devices because of the corrosion resistance, biocompatibility, exceptionally low Young’s modulus. The aim present study was to investigate histomorphometric aspects peri-implant bone around Ti-Nb-Sn alloy implants compare them with those in case commercially pure Ti (Ti). Fluorescent morphological observations ST-2 cells on substrate were performed morphogenesis rat femur evaluated. There no difference between cell morphology...
Abstract The risk of dysphagia and/or aspiration is determined using screening tests, such as the repeated saliva swallowing test and modified water test, which evaluate cued swallowing. However, humans masticate swallow foods with various consistencies, forms, amounts, without conscious awareness. Therefore, this study aimed to examine difference in behavior masticatory muscles during spontaneous versus through a series mastication processes by evaluating surface electromyogram (sEMG)...
A major component of gastric acid is hydrochloric (HCl), which can activate transient receptor potential vanilloid 1 (TRPV1). In the present study, we investigated how sustained laryngeal TRPV1 activation affects frequency swallowing reflex. Experiments were carried out on 85 male Sprague-Dawley rats. The effects short and application chemicals (3 µl 0.1 N HCl or capsaicin) time-dependent changes in occurrence evoked by supralaryngeal nerve stimulation determined. To evaluate vascular...
The effect of administering low-dose cisplatin (CDDP)-5-fluorouracil (5-FU) postoperatively on the activity immune system is not known. To clarify natural killer (NK) cell treatment with CDDP-5-FU, we compared NK after surgery for gastrointestinal cancer in patients treated a bolus dose mitomycin C (MMC) or no anticancer drug.Sixty-two consisted three groups: CDDP-5-FU (n = 15), MMC 20) and no-drug 27). Chemotherapy was initiated immediately surgery. measured day before (pre-op)...
In order to assess the long-term impact of Great East Japan Earthquake on oral health disaster victims and evaluate gene-environmental interactions in development major diseases oral-systemic associations, part two large-scale genome cohort studies by Tohoku Medical Megabank Organization (ToMMo), including Community-based (CommCohort) study Birth Three-Generation (BirThree) study, have been conducted. The population comprised 32,185 subjects, 16,886 participants CommCohort 15,299 BirThree...
Ti-6Al-4V alloy is used as biomaterials for dental and orthopedic implants because of their excellent biocompatibilities mechanical properties. However, it unclear that electron cyclotron resonance (ECR) plasma oxidation can create the oxide films on surface, this technique improves ability its osseointegration. The purpose study was to investigate characteristics calcification films. X-ray diffraction (XRD) peaks rutile phase were intensified with increasing temperature. Scanning microscopy...
Intravenous vitamin D therapy is an established treatment for secondary hyperparathyroidism (SHPT). However, no protocols have been maintenance with intravenous or oral after control of intact parathyroid hormone (iPTH) within the target range.Step I. For patients SHPT (200 ≤ iPTH 500 pg/ml), a dose 2.5 mg maxacalcitol (OCT) was administered intravenously three times week sevelamer hydrochloride; increased to 10 µg maximum < 150 pg/ml. Step II. When reached level, were assigned Group A (oral...
Feeding is a highly complex, essential behavior for survival in all species. Characterization of feeding behaviors has implications basic science and translational medicine. We have been developing methods to study using high speed videofluoroscopy (XROMM) rats while self-feeding radiopaque flavored kibble. The rat popular model medicine; however, it not studied this methodology. Towards goal, we surgically implanted fiducial markers into the skull, mandible, tongue enable motion tracking....