A5013377913- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Acute Kidney Injury Research
- Geographic Information Systems Studies
- Sodium Intake and Health
- Cardiovascular Health and Disease Prevention
- Parathyroid Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Geography Education and Pedagogy
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Geological Modeling and Analysis
- Inflammatory Biomarkers in Disease Prognosis
- Environmental Justice and Health Disparities
- Renal and Vascular Pathologies
- Data Management and Algorithms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal and related cancers
- Liver Disease Diagnosis and Treatment
- Muscle and Compartmental Disorders
- Organ Donation and Transplantation
- Cardiac Arrest and Resuscitation
- Biomedical Research and Pathophysiology
- Nutritional Studies and Diet
University of California, San Diego
2015-2024
Teva Pharmaceuticals (Australia)
2024
Novartis (Australia)
2024
VA San Diego Healthcare System
2019-2023
North Carolina Central University
2008-2023
University of San Diego
2023
Mayo Clinic
2023
Departamento Universitario Obrero Campesino
2023
University of San Simón
2023
ProMedica Toledo Hospital
2023
Background. Acute kidney injury (AKI) is common in critically ill patients and associated with high morbidity mortality. Early identification of high-risk provides an opportunity to develop strategies for prevention, early diagnosis treatment AKI. Methods. We undertook this multicenter prospective cohort study validate a risk score predicting AKI admitted intensive care unit (ICU). Patients were screened predictor variables within 48 h ICU admission. Baseline acute factors recorded at the...
Background. The widespread use of RIFLE and AKIN classification systems for acute kidney injury (AKI) diagnosis staging has established the association between AKI severity adverse outcomes. However, as a result difficulties in measuring recording urine output every hour, few prospective studies have validated criterion stated these systems. We assessed hourly ICU patients using an automated accurate device to determine if changes flow volume could be sensitive marker AKI. Additionally, we...
These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group European experts following systematic review current literature, an expert conference held in Toulouse 2016 and consensus on discussions. They summarize evidence expert-based recommendations are intended to help clinicians with these rare often complex diseases. comprise two sections. This is part one, covering topical therapies, systemic psychosocial management, communicating...
Background: Whether the increased incidence of chronic kidney disease (CKD) during intensive systolic blood pressure (SBP) lowering is accompanied by intrinsic injury unknown. Objective: To compare changes in damage biomarkers between incident CKD case participants and matched control as well (<120 mm Hg) versus standard (<140 SBP management groups SPRINT (Systolic Blood Pressure Intervention Trial). Design: Nested case–control study within SPRINT. Setting: Adults with hypertension without...
eGFR and albuminuria primarily reflect glomerular function injury, whereas tubule cell atrophy interstitial fibrosis on kidney biopsy are important risk markers for CKD progression. Kidney injury have been studied in hospitalized AKI. Here, we examined the association between urinary at baseline with subsequent loss of persons nondiabetic who participated Systolic Blood Pressure Intervention Trial (SPRINT).Among 2428 SPRINT participants (eGFR<60 ml/min per 1.73 m2) baseline, measured urine...
Increased mortality rate in chronic hemodialysis (HD) patients is partly attributed to a inflammatory state. Neutrophil-lymphocyte ratio (NLR), defined as the neutrophil count divided by lymphocyte count, increasingly recognized marker of systemic inflammation, but its prognostic value HD unknown. The aim this study was assess NLR predictor survival patient population.In incident were stratified tertiles based on measurements obtained 3 months after initiation dialysis. Multivariable Cox...
Background and objectives Higher serum phosphate is associated with cardiovascular events all-cause mortality. Explanations of this association have focused on large vessel calcification stiffness. Studies suggest that a higher induces microvascular dysfunction, but relationships in humans direct measures function are lacking. Design, setting, participants, & measurements We performed cross-sectional analysis 3189 community-living participants underwent skin capillaroscopy, laser-Doppler...
The neutrophil-to-lymphocyte ratio (NLR), defined as the neutrophil count divided by lymphocyte count, is an inexpensive and readily available parameter, which may serve a surrogate for inflammation markers, such C-reactive protein (CRP). aim of this study was to determine utility NLR in prediction elevated CRP levels hemodialysis (HD) patients.We analyzed 43,272 HD patients from 2 distinct cohorts within Monitoring Dialysis Outcomes research collaboration whom contemporaneous measurements...
People with end-stage kidney disease (ESKD) have very low physical activity, and the degree of inactivity is strongly associated morbidity mortality. We assessed feasibility effectiveness a 12-week intervention coupling wearable activity tracker (FitBit) structured feedback coaching versus alone on changes in hemodialysis patients.
Niacin downregulates intestinal sodium-dependent phosphate transporter 2b expression and reduces transport. Short-term studies have suggested that niacin lowers serum concentrations in patients with CKD ESRD. However, the long-term effects of on other mineral markers are unknown.The Atherothrombosis Intervention Metabolic Syndrome Low HDL/High Triglycerides: Impact Global Health Trial was a randomized, double-blind, placebo-controlled trial testing extended release persons prevalent...
Kidney tubular atrophy on biopsy is a strong predictor of chronic kidney disease (CKD) progression, but health poorly quantified by traditional measures including estimated glomerular filtration rate (eGFR) and albuminuria. We hypothesized that urinary biomarkers impaired tubule function would be associated with faster eGFR declines in persons CKD.We measured baseline urine concentrations uromodulin, β2-microglobulin (β2m), α1-microglobulin (α1m) among 2,428 participants the Systolic Blood...
Abstract Background Renal kallikrein (KLK1) synthesis and urinary excretion are reportedly diminished during AKI (acute kidney injury) in animal models, provision of abrogates renal injury this setting, but data human is limited. Therefore we first examined KLK1 AKI, then probed potential endocrine epigenetic mechanisms for its alterations. Methods enzymatic activity was evaluated urine from patients with established or incipient versus healthy/non-hospital as well ICU controls. Endocrine...
Endothelial dysfunction contributes to the development of acute kidney injury (AKI) in animal models ischemia reperfusion and sepsis. There are limited data on markers endothelial human AKI. We hypothesized that Protein C (PC) soluble thrombomodulin (sTM) levels could predict conducted a multicenter prospective study 80 patients assess relationship PC sTM AKI, defined by AKIN creatinine (AKI Scr) urine output criteria UO). measured marker for up 10 days from intensive care unit admission....