A5000594435- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Neuroscience of respiration and sleep
- Skin and Cellular Biology Research
- Heat shock proteins research
- Airway Management and Intubation Techniques
- Dermatological and Skeletal Disorders
- Voice and Speech Disorders
- Nail Diseases and Treatments
- Respiratory and Cough-Related Research
- Gastroesophageal reflux and treatments
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Autoimmune Bullous Skin Diseases
- Infectious Diseases and Mycology
- Toxin Mechanisms and Immunotoxins
- Social Media in Health Education
- Cerebral Venous Sinus Thrombosis
- Craniofacial Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Actinomycetales infections and treatment
- Opioid Use Disorder Treatment
- Reconstructive Facial Surgery Techniques
- Trauma and Emergency Care Studies
- Pesticide Exposure and Toxicity
University Hospital of Bern
2018-2021
Kaiser Permanente Santa Clara Medical Center
2019-2021
Stanford Medicine
2018-2019
University of Bern
2018
Northwestern University
2013-2018
Stanford University
2018
Kaiser Permanente
2018
Tripler Army Medical Center
2018
Stanford Health Care
2017-2018
Lurie Children's Hospital
2015
An analysis of NIH funding in 1996 found that the strongest predictor funding, disability-adjusted life-years (DALYs), explained only 39% variance funding. In 1998, Congress requested Institute Medicine (IOM) evaluate priority-setting criteria for funding; IOM recommended greater consideration disease burden. We examined whether association between current burden and has changed since time.We analyzed public data on 2006 29 common conditions. Measures US 2004 were obtained from World Health...
<h3>Importance</h3> Papillary thyroid carcinoma (PTC) is the most common endocrine neoplasm. B-type raf kinase (<i>BRAF</i>) V600E mutation has been proposed as a negative prognostic indicator in PTC, and patients harboring it should receive more aggressive initial therapy. <h3>Objective</h3> To assess significance of<i>BRAF</i>V600E PTC largest US sample to date. <h3>Design</h3> We identified from our institution's pathology archives diagnosed having meeting criteria for<i>BRAF</i>mutation...
These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group European experts following systematic review current literature, an expert conference held in Toulouse 2016, and consensus on discussions. summarize evidence expert-based recommendations intend to help clinicians with these rare often complex diseases. comprise two sections. This is part two, covering complications particularities some forms ichthyosis.
These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group European experts following systematic review current literature, an expert conference held in Toulouse 2016 and consensus on discussions. They summarize evidence expert-based recommendations are intended to help clinicians with these rare often complex diseases. comprise two sections. This is part one, covering topical therapies, systemic psychosocial management, communicating...
The epidermal growth factor receptor (EGFR) has been targeted for inhibition using tyrosine kinase inhibitors and monoclonal antibodies, with improvement in outcome subsets of patients head neck, lung, colorectal carcinomas. We have previously found that EGFR stability plays a key role cell survival after chemotherapy radiotherapy. Heat shock protein 90 (HSP90) is known to stabilize mutant ErbB2, but its cancers wild-type (WT) WT-EGFR unclear. In this report, we demonstrate fully mature,...
Characterization of leadership within otolaryngology is key to evaluating trends and promoting program advancement. This study evaluates representation women in holding residency fellowship directorships, or chair positions, comparing sex differences academic rank, years practice, scholarly activity.Cross sectional analysis.A comprehensive list directors from Accreditation Council for Graduate Medical Education-accredited programs 2017 2018 was compiled. Academic rank practice were...
To assess if there is a significant difference in the prevalence and severity of chronic cough symptoms obstructive sleep apnea (OSA) patients versus non-OSA examine this relationship regard to laryngopharyngeal reflux (LPR) symptoms.Prospective cohort study.Patients referred Northwestern Medicine Sleep Lab for home testing were enrolled. Patients filled out Leicester Cough Questionnaire (LCQ) Reflux Symptom Index (RSI) before completing testing. Home results reviewed, separated into OSA...
Objectives/Hypothesis Otolaryngologic symptoms of obstructive sleep apnea (OSA) and their diagnostic utility are not well studied. We aimed to elucidate the prevalence otolaryngologic among patients being evaluated for OSA. Given findings that Reflux Symptom Index (RSI) was strongly associated with OSA status, we RSI predicting status. Study Design Cross‐sectional. Methods recruited 101 adults presenting ambulatory polysomnograms Northwestern Sleep Disorders Center from July 2017 2018. The...
Summary Background Patients with severe autosomal recessive congenital ichthyosis (ARCI) show a T helper 17/interleukin 17 (Th17/IL17) skewing in their skin and serum, resembling the inflammatory profile of psoriatic patients. Secukinumab, an IL‐17A inhibitor, has shown clinical efficacy patients moderate‐to‐severe plaque psoriasis. Aims To test safety secukinumab paediatric patient ATP‐binding cassette subfamily A member 12 deficiency‐related erythrodermic ARCI. Materials & Methods...
To identify the rate of hearing loss related to middle ear disease and frequency tympanostomy tube (TT) insertion in contralateral patients with unilateral microtia/aural atresia.Retrospective case series less than 3 years age atresia treated at an urban, tertiary care children's hospital from 2008 2013.Clinical audiologic data were reviewed. Statistical analysis was performed determine relative risk TT normal ear.A total 72 included for analysis. The average their initial otolaryngology...
Objective Assess the frequency and nature of postoperative complications following sleep surgery. Examine these issues specifically in elderly patients to provide guidance for their perioperative care. Study Design Retrospective cohort study. Setting American College Surgeons National Surgical Quality Improvement Program. Methods We identified with obstructive apnea undergoing surgery procedures from 2006 2013 Program, a multi‐institutional outcomes program designed improve surgical quality....
Objectives/Hypothesis Examine trends in clinical research and levels of evidence related to obstructive sleep apnea (OSA) the medical literature. Describe features OSA within otolaryngology journals. Study Design Retrospective analysis. Methods Review articles from 2006, 2011, 2016 four leading Level was graded, study characteristics were measured. Results Seven hundred eight total reviewed. significantly increased both number proportion ( P < .001) = .004) Surgically focused did not...
Objectives/Hypothesis Our objectives were to describe otolaryngology residency programs' experience in and attitudes toward sleep surgery, current fellowships their impact on future academic practice. Study Design E‐mail survey. Methods A survey was e‐mailed program directors of 106 Accreditation Council for Graduate Medical Education‐accredited residencies assessing resident medicine experience, satisfaction, faculty. separate sent the seven fellowships. Frequency graduates pursuing careers...
To describe current levels and trends of funding for the National Institutes Health (NIH) in obstructive sleep apnea (OSA) to recognize status otolaryngologists OSA research.Scientometric analysis.The NIH RePORTER database was queried search term "obstructive apnea" all available years. Sex, degree, academic department, source, geography, totals years, h-index principal investigators (PIs) were collected summarized.A total 397 projects spanning 1242 years funded. Of 273 individual PIs, 33.3%...
Patients are accessing online health information frequently and using it to guide treatment decisions. Few studies have been done assessing obstructive sleep apnea (OSA) information, no examined surgical resources for these patients. This was a cross-sectional analysis. “Sleep surgery” “sleep were entered into Google, MSN Bing, Yahoo! search engines. The first 25 results of each individual evaluated. Each unique site assessed content quality, accessibility, usability, reliability,...