A5059504674- Endoplasmic Reticulum Stress and Disease
- interferon and immune responses
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Genetics and Neurodevelopmental Disorders
- Immune cells in cancer
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
European Molecular Biology Organization
2023
Heidelberg University
2021-2023
German Cancer Research Center
2022-2023
Heidelberg Institute for Stem Cell Technology and Experimental Medicine
2023
University Hospital Heidelberg
2021-2022
National Center for Tumor Diseases
2021-2022
Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR-activation screens hypersensitive cells, we identify selenoprotein P (SELENOP) receptor, LRP8, a key determinant protecting MYCN-amplified neuroblastoma cells from ferroptosis. Genetic deletion of LRP8 leads to result insufficient supply selenocysteine, which is required...
IDH mutant gliomas are grouped into astrocytomas or oligodendrogliomas depending on the codeletion of chromosome arms 1p and 19q. Although genomic alterations have been well described, transcriptional changes unique to either tumor type not fully understood. Here, we identify Tripartite Motif Containing 67 (TRIM67), an E3 ubiquitin ligase with essential roles during neuronal development, as oncogene distinctly upregulated in oligodendrogliomas.We used several cell lines, including...
Abstract Understanding the operational molecular, and metabolic networks that determine balance between pro- anti-ferroptotic regulatory pathways could unravel unique vulnerabilities to be exploited for cancer therapy. Here we identify selenoprotein P (SELENOP) receptor, LRP8, as a key determinant protecting MYCN-amplified neuroblastoma cells from ferroptosis in vitro orthotopic mouse models. Specifically, exquisite dependency on LRP8-mediated selenocysteine import is caused by failure of...
Abstract Oligodendrogliomas are a subtype of isocitrate dehydrogenase (IDH) mutant gliomas defined by the co-deletion chromosome arms 1p and 19q. Although somatic genomic alterations oligodendrogliomas have been well described, transcriptional changes unique to these tumors not studied. Here, we identify Tripartite Motif Containing 67 (TRIM67), an E3 ubiquitin ligase with essential roles during neuronal development, as oncogene distinctly upregulated in oligodendrogliomas. We characterize...
Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis could unravel vulnerabilities that can be harnessed for therapeutic benefit. Using CRISPR-activation screens hypersensitive cells, we identify selenoprotein P (SELENOP) receptor, LRP8, a key determinant protecting MYCN-amplified neuroblastoma cells from ferroptosis. Genetic deletion of LRP8 leads to due insufficient supply selenocysteine, which is required...