A5029769695- Skin and Cellular Biology Research
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Fibroblast Growth Factor Research
- Molecular Biology Techniques and Applications
- Wnt/β-catenin signaling in development and cancer
- Liver Diseases and Immunity
- Nuclear Structure and Function
- Liver physiology and pathology
- Porphyrin Metabolism and Disorders
- Hepatitis B Virus Studies
- Microtubule and mitosis dynamics
- Biosimilars and Bioanalytical Methods
- Pediatric Hepatobiliary Diseases and Treatments
- Dermatological and Skeletal Disorders
- Ethics in Clinical Research
- Peroxisome Proliferator-Activated Receptors
- Heat shock proteins research
- Virus-based gene therapy research
- Liver Disease and Transplantation
- Alkaline Phosphatase Research Studies
- Pharmacological Effects and Toxicity Studies
- Alcohol Consumption and Health Effects
- Cellular transport and secretion
Medical University of Graz
2007-2023
Biobanking and Biomolecular Resources Research Infrastructure Consortium
2018
Center for Clinical Research (United States)
2007
Université Paris-Est Créteil
2007
Mylan (Switzerland)
2007
University of Graz
1996-2003
German Cancer Research Center
1999
Heidelberg University
1999
Artificial Intelligence (AI) for the biomedical domain is gaining significant interest and holds considerable potential future of healthcare, particularly also in context vitro diagnostics. The European In Vitro Diagnostic Medical Device Regulation (IVDR) explicitly includes software its requirements. This poses major challenges devices (IVDs) that involve Machine Learning (ML) algorithms data analysis decision support. can increase difficulty applying some most successful ML Deep (DL)...
Mallory bodies (MBs) consist of abnormal keratins, ubiquitin, heat shock proteins, and the protein p62. p62 is encoded by an immediate-early response gene that rapidly responds to a variety extracellular signals involved in cell proliferation, differentiation, particularly oxidative stress. It acts as adapter signal transduction binds noncovalently possibly being regulation fate ubiquitinated proteins segregation ( i.e. , sequestosome or aggresome formation). The presence together with...
Mallory bodies (MBs) and intracellular hyaline (IHBs) are cytoplasmic hepatocellular inclusions that consist of aggregated proteins. MBs characteristically associated with alcoholic non-alcoholic steatohepatitis, but may also be found in chronic cholestatic metabolic (eg copper intoxication) diseases neoplasms, particularly carcinomas. IHBs have hitherto only been described carcinoma cells. In the present study carcinomas (HCCs) a case idiopathic toxicosis were evaluated respect to presence...
Cholestasis is associated with retention of bile acids and reduced expression the Na + /taurocholate cotransporter (Ntcp), major hepatocellular acid uptake system. This study aimed to determine whether downregulation Ntcp in obstructive cholestasis 1) a consequence 2) mediated by induction transcriptional repressor short heterodimer partner 1 (SHP-1). To time course for changes serum levels as well SHP-1 steady-state mRNA levels, mice were subjected common duct ligation (CBDL) 3, 6, 12, 24,...
Mallory bodies (MBs) and intracellular hyaline (IHBs) are characteristic hepatocellular inclusions. MBs hallmarks of steatohepatitis, whereas IHBs have first been detected in carcinoma. contain ubiquitin sequestosome 1/p62 (p62), a stress-inducible adapter protein with affinity to polyubiquitinated proteins. differ from by their keratin content morphology. In vitro transfections were undertaken study under defined conditions MB IHB formation, pathogenesis, relationship. CHO-K1, TIB73, HeLa...
Steatohepatitis (SH) and SH-associated hepatocellular carcinoma (HCC) are of considerable clinical significance. SH is morphologically characterized by steatosis, liver cell ballooning, cytoplasmic aggregates termed Mallory-Denk bodies (MDBs), inflammation, fibrosis at late stage. Disturbance the keratin cytoskeleton aggregation keratins (KRTs) essential for MDB formation. We analyzed livers aged Krt18-/- mice that spontaneously developed in majority cases HCC independent sex. Interestingly,...