- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Cardiac pacing and defibrillation studies
- Ultrasound and Hyperthermia Applications
- Neuroscience and Neural Engineering
- Cardiac Arrhythmias and Treatments
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Gastrointestinal Bleeding Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Transcranial Magnetic Stimulation Studies
- Silicon Carbide Semiconductor Technologies
- Atomic and Subatomic Physics Research
- Wireless Body Area Networks
- Cardiac electrophysiology and arrhythmias
- Handwritten Text Recognition Techniques
- EEG and Brain-Computer Interfaces
- Brain Tumor Detection and Classification
- Smart Systems and Machine Learning
- Wireless Power Transfer Systems
- Electronic Packaging and Soldering Technologies
- Voice and Speech Disorders
- Radiation Effects and Dosimetry
Northwestern University
2020-2025
Intel (United States)
2024
Case Western Reserve University
2018
Patients with deep brain stimulation (DBS) implants have limited access to MRI due safety concerns associated RF-induced heating. Currently, in these patients is allowed 1.5T horizontal bore scanners utilizing pulse sequences reduced power. However, the use of 3T such increasingly reported based on assessments. Here we present results comprehensive RF heating measurements for two commercially available DBS systems during at and 3T.To assess effect imaging landmark, lead configuration,...
Patients with active implants such as deep brain stimulation (DBS) devices are often denied access to MRI due safety concerns associated the radiofrequency (RF) heating of their electrodes. The majority studies on RF conductive have been performed in horizontal close-bore scanners. Vertical scanners which a 90° rotated transmit coil generate fundamentally different electric and magnetic field distributions, yet very little is known about this class We numerical simulations well phantom...
Ultra-high field MRI at 7 T can produce much better visualization of sub-cortical structures compared to lower field, which greatly help target verification as well overall treatment monitoring for patients with deep brain stimulation (DBS) implants. However, use such is currently contra-indicated by guidelines from the device manufacturers due safety issues. The aim this study was provide an assessment and image quality ultra-high magnetic resonance imaging in We performed experiments both...
Patients with active implants such as deep brain stimulation (DBS) devices have limited access to magnetic resonance imaging (MRI) due risks associated RF heating of in MRI environment. With an aging population and increased prevalence neurodegenerative disease, the indication for exams patients increases well. In response this growing need, many groups investigated strategies mitigate DBS during MRI. These efforts fall into two main categories: field-shaping methods, where electric field...
Interaction of an active electronic implant such as a deep brain stimulation (DBS) system and MRI RF fields can induce excessive tissue heating, limiting accessibility. Efforts to quantify heating mostly rely on electromagnetic (EM) simulations assess individualized specific absorption rate (SAR), but require extensive computational resources. Here, we investigate if predictive model using machine learning (ML) predict the local SAR in around tips implanted leads from distribution tangential...
The majority of studies that assess magnetic resonance imaging (MRI) induced radiofrequency (RF) heating the tissue when active electronic implants are present have been performed in horizontal, closed-bore MRI systems. Vertical, open-bore systems a 90° rotated magnet and fundamentally different RF coil geometry, thus generating substantially field distribution inside body. Little is known about elongated such as deep brain stimulation (DBS) devices this class scanners. Here, we conducted...
To assess RF-induced heating during MRI of patients with implanted stereo-electroencephalography electrodes.Simulations and experimental measurements using phantom a head-only transmit/receive coil on 3T MR system were performed to evaluate temperature increases at the tip an 8-contact electrode insulated wire partially immersed into phantom. The lengths producing maximum (resonant condition) minimum (anti-resonant evaluated for different entry modes penetration depths.For both electrode,...
Radiofrequency (RF) tissue heating around deep brain stimulation (DBS) leads is a well-known safety risk during MRI, resulting in strict imaging guidelines and limited allowable protocols. The implanted lead's trajectory orientation with respect to the MRI electric fields contribute variations magnitude of RF across patients. Currently, there are no surgical requirements for implanting extracranial portion DBS lead, substantial clinical lead trajectories consequently heating. Recent studies...
Abstract Purpose Low‐field MRI has been assumed to be implant‐friendly based on limited studies. However, radiofrequency (RF)–induced heating due an implant is a complex resonance phenomenon, highly dependent the implant's configurations and applied RF frequencies. This study aims evaluate of deep brain stimulation (DBS) implants during at low field strengths compared with higher‐field 1.5T MRI. Methods A commercial DBS was used in full system as well lead‐only compare 0.55 T 1.5 T. The...
After epicardial cardiac implantable electronic devices are implanted in pediatric patients, they become ineligible to receive MRI exams due an elevated risk of RF heating. We investigated whether simple modifications the trajectories leads could substantially and reliably reduce heating during at 1.5 T, with benefits extending abandoned leads.
Abstract Purpose To evaluate the safety of MRI in patients with fragmented retained leads (FRLs) through numerical simulation and phantom experiments. Methods Electromagnetic thermal simulations were performed to determine worst‐case RF heating 10 patient‐derived FRL models during at 1.5 T 3 imaging landmarks corresponding head, chest, abdomen. measurements phantoms implanted reconstructed that produced highest simulations. The potential for unintended tissue stimulation was assessed a...
Radiofrequency (RF) heating of tissue during magnetic resonance imaging (MRI) is a known safety risk in the presence active implantable medical devices (AIMDs). As result, access to MRI limited for patients with these implants including those deep brain stimulation (DBS) systems. Numerous factors contribute excessive RF at DBS lead-tip, most notable being trajectory lead. Phantom studies have demonstrated that looping extracranial portion lead surgical burr hole reduces lead-tip; however,...
Patients with congenital heart defects, inherited arrhythmia syndromes, and disorders of cardiac conduction often receive a implantable electronic device (CIED). At least 75% patients CIEDs will need magnetic resonance imaging (MRI) during their lifetime. In 2011, the US Food Drug Administration approved first MR-conditional for endocardial systems, in which leads are passed through vein affixed to endocardium. The majority children, however, an epicardial CIED, where directly sewn...
This study focused on the potential risks of radiofrequency-induced heating cardiac implantable electronic devices (CIEDs) in children and adults with epicardial endocardial leads varying lengths during cardiothoracic MRI scans. Infants young are primary recipients CIEDs, though have not been approved as MR conditional by FDA due to limited data, leading pediatric hospitals either refusing service most CIED patients or adopting a scan-all strategy based results from adult studies. The argues...
Magnetic Resonance Imaging (MRI) access remains conditional to patients with conductive medical implants, as RF heating generated around the implant during scanning may cause tissue burns. Experiments have been traditionally used assess this heating, but they are time-consuming and expensive, in many cases cannot faithfully replicate in-vivo scenario. Alternatively, ISO TS 10974 outlines a four-tier assessment approach based on combination of experiments full-wave electromagnetic (EM)...
Infants and children with congenital heart defects often receive a cardiac implantable electronic device (CIED). Because transvenous access to the is difficult in patients small veins, majority of young epicardial CIEDs. Unfortunately, however, once an CIED placed, are no longer eligible magnetic resonance imaging (MRI) exams due unknown risk MRI-induced radiofrequency (RF) heating device. Although many studies have assessed role configuration RF endocardial CIEDs adults, such case for...
Patients with deep brain stimulation (DBS) implants are often denied access to magnetic resonance imaging (MRI) due safety concerns associated RF heating of implants. Although MR-conditional DBS devices available, complying manufacturer guidelines has proved be difficult as pulse sequences that optimally visualize target structures tend have much higher specific absorption rate (SAR) radiofrequency energy than current allow. The MR-labeling devices, well the majority studies on conductive...
Abstract Purpose To develop and test an MRI coil assembly for imaging deep brain stimulation (DBS) at 3 T with a reduced level of local specific absorption rate RF fields near the implant. Methods A mechanical rotatable linearly polarized birdcage transmitter outfitted 32‐channel receive array was constructed. The performance image quality were systematically evaluated using bench‐level measurements tests, including SNR maps, element noise correlation, acceleration capabilities....
Deep brain stimulation (DBS) is a common treatment for variety of neurological and psychiatric disorders. Recent studies have highlighted the role neuroimaging in localizing position electrode contacts relative to target areas order optimize DBS programming. Among different imaging methods, postoperative magnetic resonance (MRI) has been widely used localization; however, geometrical distortion induced by lead limits its accuracy. In this work, we investigated what degree difference between...
Patients with deep brain stimulation (DBS) devices have limited access to magnetic resonance imaging (MRI) due safety concerns associated RF heating generated around the implant. The problem of predicting conductive leads is complex a large parameter space and several interplaying factors. Recently however, off-label use MRI in patients DBS has been reported based on assessments, raising concern that potentially dangerous scenarios may overlooked. In this work, we present results systematic...
Patients with long conductive implants such as deep brain stimulation (DBS) leads are often denied access to magnetic resonance imaging (MRI) exams due safety concerns associated radiofrequency (RF) heating of implants. Experimental temperature measurements in tissue-mimicking gel phantoms under MRI RF exposure conditions common practices predict in-vivo the tissue surrounding wire Such experiments both expensive-as they require units-and time-consuming complex implant setups. Recently,...
Purpose In this study, the effects of RF coupling on magnitude and spatial patterns RF‐induced heating near multiple wire‐like conducting implants (such as simultaneous electrical stimulation stereoelectroencephalography electrodes) during MRI were assessed. Methods Simulations experimental measurements temperature increases partially immersed conductors performed using a phantom with transmit/receive head coil 3T system. The consisted either pair wires or single electrode contacts,...
Radiofrequency (RF) induced tissue heating around deep brain stimulation (DBS) leads is a well-known safety risk during magnetic resonance imaging (MRI), hindering routine protocols for patients. Known factors that contribute to variations in the magnitude of RF across patients include implanted lead's trajectory and its orientation with respect MRI electric fields. Currently, there are no consistent requirements surgically implanting extracranial portion DBS lead. Recent studies have shown...
Advances in low-field magnetic resonance imaging (MRI) are making more accessible without significant losses image quality. In addition to being cost-effective and easier place as much needed infrastructure, it has been publicized that the lower field strengths make MRI safer for patients with implants. To test this claim, we conducted a total of 368 simulations wires various lengths geometries gel phantom during radiofrequency (RF) exposure at 23 MHz 63.6 (corresponding 0.55 T 1.5 T). Our...