A5015759606- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neural Engineering
- Regulation of Appetite and Obesity
- Immune cells in cancer
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Cancer Immunotherapy and Biomarkers
- Neurogenesis and neuroplasticity mechanisms
- Congenital heart defects research
- Pancreatic function and diabetes
- Advanced biosensing and bioanalysis techniques
- Autism Spectrum Disorder Research
- Cancer Cells and Metastasis
- Analytical Chemistry and Sensors
- Conducting polymers and applications
Massachusetts Institute of Technology
2012-2022
McGovern Institute for Brain Research
2016-2020
Singapore Bioimaging Consortium
2016
Agency for Science, Technology and Research
2016
Institute of Bioengineering and Nanotechnology
2009
Abstract Despite the increasing interest in targeting stromal elements of tumor microenvironment, we still face tremendous challenges developing adequate therapeutics to modify landscape. A major obstacle this is our poor understanding phenotypic and functional heterogeneity cells tumors. Herein, perform an unbiased interrogation mesenchymal cells, delineating co-existence distinct subsets cancer-associated fibroblasts (CAFs) microenvironment murine carcinomas, each endowed with unique...
Although cholinergic innervation of the cortex by nucleus basalis (NB) is known to modulate cortical neuronal responses and instruct plasticity, little about underlying cellular mechanisms. Using cell-attached recordings in vivo, we demonstrate that electrical stimulation NB, paired with visual stimulation, can induce significant potentiation excitatory neurons primary mice. We further show vivo two-photon calcium imaging, ex whole-cell this pairing-induced mediated direct activation...
Multiple hypothalamic neuronal populations that regulate energy balance have been identified. Although glia exist in abundance and form intimate structural connections with neurons, their roles homeostasis are less known. Here we show selective Ca2+ activation of the mouse arcuate nucleus (ARC) reversibly induces increased food intake while disruption signaling pathway ARC reduces intake. The specific enhances activity agouti-related protein/neuropeptide Y (AgRP/NPY)-expressing neurons but...
An oligonucleotide-grafted poly(3,4-ethylenedioxythiophene) (PEDOT) thin film is developed for three DNA biosensor detection methods, including fluorescence, quartz crystal microbalance, and electrochemical methods. By electrocopolymerization of hydroxyl-functionalized EDOT carboxylic-functionalized in microemulsion solutions, ultrasmooth films with a controlled surface density carboxylic groups are created. The probe oligonucleotides immobilized on PEDOT by using N-hydroxysuccinimide...
Here we demonstrate a facile method by which to deliver complex spatiotemporal stimulation neural networks in fast patterns, trigger interesting forms of circuit-level plasticity cortical areas. We present complete platform patterns electricity can be arbitrarily defined and distributed across brain circuit, either simultaneously, asynchronously, or that easily designed orchestrated with precise timing. Interfacing acute slices mouse cortex, show our system used activate neurons at many...