A5062879363- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Polydiacetylene-based materials and applications
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- Silk-based biomaterials and applications
- Antimicrobial Peptides and Activities
- Bone and Dental Protein Studies
- Nanoparticle-Based Drug Delivery
- Chemical Synthesis and Analysis
- Proteoglycans and glycosaminoglycans research
- Polymer Surface Interaction Studies
- Osteoarthritis Treatment and Mechanisms
- Neuroscience and Neuropharmacology Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Peptidase Inhibition and Analysis
- Nicotinic Acetylcholine Receptors Study
- Protein Hydrolysis and Bioactive Peptides
- Wound Healing and Treatments
- Force Microscopy Techniques and Applications
- Neurological disorders and treatments
- Characterization and Applications of Magnetic Nanoparticles
Google (United States)
2025
Bilkent University
2012-2023
University of Chicago
2020
National Nanotechnology Research Center
2014-2019
National Nanotechnology Center
2016-2018
Ankara (Czechia)
2016-2018
Institute of Nanotechnology
2017
Gazi University
2014-2016
Turkish Aerospace Industries (Turkey)
2014
Izmir Kâtip Çelebi University
2012
New blood vessel formation (angiogenesis) is one of the most important processes required for functional tissue formation. Induction angiogenesis usually triggered by growth factors released cells. Glycosaminoglycans (e.g., heparan sulphates) in extracellular matrix aid proper functioning these factors. Therefore, exogeneous heparin or were promoting previous regenerative medicine studies. Here we report first time induction a synthetic nanofibrous peptide scaffold without addition any...
Abstract A general drawback of supramolecular peptide networks is their weak mechanical properties. In order to overcome a similar challenge, mussels have adapted pH‐dependent iron complexation strategy for adhesion and curing. This also provides successful stiffening self‐healing The present study inspired by the mussel curing establish cross‐link points in self‐assembled networks. impact peptide‐iron on morphology secondary structure nanofibers characterized scanning electron microscopy,...
Significance Essential tremor is one of the most frequent movement disorders humans, but its causes remain largely unknown. In a six-generation family with both essential and Parkinson disease, we identified rare missense mutation HTRA2 as causative allele. Family members homozygous for this allele were more severely affected than those heterozygous The same had been associated characteristics in mouse mutants disease some, not all, epidemiologic studies. Our results suggest that may be...
Anxiety disorders are the most prevalent mental in developed societies. Although roles for prefrontal cortex, amygdala, hippocampus and mediodorsal thalamus anxiety well documented, molecular mechanisms contributing to functions of these structures poorly understood. Here we report that deletion Lynx2, a mammalian prototoxin gene is expressed at high levels associated brain areas, results elevated anxiety-like behaviors. We show LYNX2 can bind modulate neuronal nicotinic receptors, loss...
Immobilization of growth factors in scaffolds is important for controlling their dose and bioactivity regenerative medicine applications. Although numerous covalent noncovalent immobilization strategies have been proposed, better factor loading control inside the scaffold necessary. Nature binding site on interacting with critical preserving achieving maximal functionality, which has a relatively less emphasized issue previous studies. We recently reported heparin mimetic peptide nanofibers,...
Glycosaminoglycans (GAGs) and glycoproteins are vital components of the extracellular matrix, directing cell proliferation, differentiation, migration tissue homeostasis. Here, we demonstrate supramolecular GAG-like glycopeptide nanofibers mimicking bioactive functions natural hyaluronic acid molecules. Self-assembly amphiphile molecules enable organization glucose residues in close proximity on a nanoscale structure forming system. Our vitro culture results indicated that recognized through...
Abstract Understanding the toxicity of nanomaterials remains largely limited to acute cellular response, i.e., short-term in vitro cell-death based assays, and analyses tissue- organ-level accumulation clearance patterns animal models, which have produced very little information about how these materials (from point view) interact with complex intracellular machinery. In particular, understanding mechanism caused by gradual due prolonged exposure times is essential yet still continue be a...
The biological basis for the development of cerebro-cerebellar structures required posture and gait in humans is poorly understood. We investigated a large consanguineous family from Turkey exhibiting an extremely rare phenotype associated with quadrupedal locomotion, mental retardation, hypoplasia, linked to 7.1-Mb region homozygosity on chromosome 17p13.1–13.3. Diffusion weighted imaging fiber tractography patients' brains revealed morphological abnormalities cerebellum corpus callosum,...
Natural extracellular matrix (ECM) consists of complex signals interacting with each other to organize cellular behavior and responses. This sophisticated microenvironment can be mimicked by advanced materials presenting essential biochemical physical properties in a synergistic manner. In this work, we developed facile fabrication method for novel nanofibrous self-assembled peptide amphiphile (PA) poly(ethylene glycol) (PEG) composite hydrogel system independently tunable biochemical,...
Recognition of molecules and regulation extracellular matrix synthesis are some the functions enzymes in addition to their catalytic activity. While a diverse array enzyme-like materials have been developed, these efforts largely confined imitation chemical structure activity enzymes, it is unclear whether enzyme-mimetic can also be used replicate matrix-regulatory roles ordinarily performed by natural enzymes. Self-assembled peptide nanofibers provide multifunctional properties, as active...
Peptide amphiphiles (PAs) self-assemble into supramolecular nanofiber gels that provide a suitable environment for encapsulation of both hydrophobic and hydrophilic molecules. The PA have significant advantages controlled delivery applications due to their high capacity retain water, biocompatibility, biodegradability. In this study, we demonstrate injectable drug applications. Doxorubicin (Dox), as widely used chemotherapeutic breast cancer treatment, was encapsulated within the prepared at...
Antisense oligonucleotides provide a promising therapeutic approach for several disorders including cancer. Chemical stability, controlled release, and intracellular delivery are crucial factors determining their efficacy. Gels composed of nanofibrous peptide network have been previously suggested as carriers drugs to improve stability but not used oligonucleotide delivery. In this work, self-assembled system is formed by mixing cationic amphiphile (PA) with Bcl-2 antisense...
Label free imaging of the chemical environment biological specimens would readily bridge supramolecular and cellular scales, if a fingerprint technique such as Raman scattering can be coupled with super resolution imaging. We demonstrate possibility label-free super-resolution imaging, by applying stochastic reconstruction to temporal fluctuations surface enhanced (SERS) signal which originate from biomolecular layers on large-area plasmonic surfaces high uniform hot-spot density (>1011/cm2,...
Essential amino acids in catalytic sites of native enzymes are important nature inspired catalyst designs.
Peptide amphiphiles are a class of self-assembling molecules that widely used to form bioactive nanostructures for various applications in bionanomedicine. However, peptide can exhibit distinct behaviors under different conditions, suggesting environmental variables such as temperature, pH, electrolytes and the presence biological factors may greatly affect self-assembly process. In this work, we united-atom molecular dynamics simulations understand effects three counterions (Na+, Ca2+ at pH...