A5075061980- Immune Cell Function and Interaction
- Marine and coastal plant biology
- Reproductive biology and impacts on aquatic species
- T-cell and B-cell Immunology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immunotherapy and Immune Responses
Max Planck Institute for Biology
2024
Max Planck Institute for Developmental Biology
2024
Instituto Gulbenkian de Ciência
2022
Calouste Gulbenkian Foundation
2022
SUMMARY Sex chromosomes fall into three classes: XX/XY, ZW/ZZ and U/V systems. The rise, evolution demise of systems have remained enigmatic to date. Here, we analyze genomes spanning the entire brown algal phylogeny decipher their sex-determination evolutionary history. birth sex evolved more than 250 million years ago, when a pivotal male-determinant located in discrete region proto-U proto-V ceased recombining. Over time, nested inversions led step-wise expansions, accompanying increasing...
IL-7 and IL-7R are essential for T lymphocyte differentiation by driving proliferation survival of specific developmental stages. Although early lineage progenitors (ETPs), the most immature thymocyte population known, have a history expression, it is unclear whether required at this stage. In study, we show that mice lacking or marked loss ETPs results mostly from cell-autonomous defect in survival, although no changes were detected Bcl2 protein levels. Furthermore, fraction responded to...