A5112404444- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related gene regulation
- Meat and Animal Product Quality
- Medicinal Plants and Bioactive Compounds
- Clostridium difficile and Clostridium perfringens research
- Peptidase Inhibition and Analysis
- Cannabis and Cannabinoid Research
- Reproductive Biology and Fertility
- Effects of Environmental Stressors on Livestock
- Circadian rhythm and melatonin
- Pharmacological Effects of Natural Compounds
- CRISPR and Genetic Engineering
- Plant Molecular Biology Research
- Molecular Biology Techniques and Applications
- Ruminant Nutrition and Digestive Physiology
Zhejiang University
2022-2025
Ministry of Agriculture and Rural Affairs
2023
Jiangxi Agricultural University
2016-2022
Zhejiang Gongshang University
2022
Abstract Bamaxiang pig is from Guangxi province in China, characterized by its small body size and two‐end black coat colour. It an important indigenous breed for local pork market excellent animal model biomedical research. In this study, we performed genomewide association studies (GWAS) on 43 growth carcass traits 315 purebred pigs based a 1.4 million SNP array. We observed considerable phenotypic variability the pigs. The corresponding heritability varied greatly across ranged 9.0% to...
Abstract Background Pigs are crucial sources of meat and protein, valuable animal models, potential donors for xenotransplantation. However, the existing reference genome pigs is incomplete, with thousands segments centromeres telomeres missing, which limits our understanding important traits in these genomic regions. Findings We present a near-complete assembly Jinhua pig (JH-T2T) provide set diploid genomes, constructed using PacBio HiFi, ONT long reads, Hi-C reads. This includes all 18...
Short tandem repeats (STRs) were recently found to have significant impacts on gene expression and diseases in humans, but their roles complex traits pigs remain unexplored. This study investigates the effects of STRs liver tissues based whole-genome sequences RNA-Seq data a discovery cohort 260 F6 individuals validation population 296 F7 from heterogeneous generated crosses among eight pig breeds.We identified 5203 5868 significantly (eSTRs, FDR < 1%) populations, respectively, most which...
Intramuscular fat (IMF) content is a critical indicator of pork quality, and abnormal IMF also relevant to human disease as well aging. Although N6-methyladenosine (m6A) RNA modification was recently found regulate adipogenesis in porcine intramuscular fat, however, the underlying molecular mechanisms still unclear. In this work, we collected 20 longissimus dorsi muscle samples with high (average 3.95%) or low 1.22%) from unique heterogenous swine population for m6A sequencing (m6A-seq). We...
Abstract Background Short tandem repeats (STRs) are genetic markers with a greater mutation rate than single nucleotide polymorphisms (SNPs) and widely used in studies forensics. However, most pigs have focused only on SNPs or limited number of STRs. Results This study screened 394 deep-sequenced genomes from 22 domesticated pig breeds/populations worldwide, wild boars both Europe Asia, numerous outgroup Suidaes, identified set 878,967 polymorphic STRs (pSTRs), which represents the largest...
Genome wide association analyses in diverse populations can identify complex trait loci that are specifically present one population or shared across multiple populations, which help to better understand the genetic architecture of traits a broader context. In this study, we conducted genome-wide studies and meta-analysis for 38 fatty acid composition with 12-19 million imputed genome sequence SNPs 2446 pigs from six encompassing White Duroc × Erhualian F2, Sutai, Duroc-Landrace-Yorkshire...
Abstract Structural variations (SVs) are important DNA polymorphisms that contribute to genetic diversity and evolution in humans, animals, plants. In this study, we present a novel swine SV dataset of 79,919 deletions, 23,638 duplications, 9333 inversions with average sequence depths 24.1× from 24 varieties worldwide pig populations, encompassing 305 individuals. Genotypes SVs, particularly can accurately group individuals based on their population identity. We showed exon‐covering...
Summary We have generated a large heterogenous stock population by intercrossing eight divergent pig breeds for multiple generations. analyzed the composition of intestinal microbiota at different ages and anatomical locations in > 1,000 6 th - 7 generation animals. show that, under conditions exacerbated genetic yet controlled environmental variability, abundance specific taxa (including Christensenellaceae ) are heritable this monogastric omnivore. fine-map QTL with major effect on...
Abstract BackgroundIntramuscular fat (IMF) content is critical indicator of pork quality, and abnormal IMF also relevant to human disease as well aging. Although N6-methyladenosine (m 6 A) RNA modification was recently found regulate adipogenesis in porcine intramuscular fat, however, the understanding underlying molecular mechanism still limited. ResultsIn this work, we collected 20 longissimus dorsi muscle (LDM) samples with high low from a unique heterogenous swine population for m A...