A5046507906- Sepsis Diagnosis and Treatment
- Renal function and acid-base balance
- Cardiac Arrest and Resuscitation
- Emergency and Acute Care Studies
- Electrolyte and hormonal disorders
- Hemodynamic Monitoring and Therapy
- Anesthesia and Sedative Agents
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Healthcare Systems and Practices
- Diet and metabolism studies
- Health, Medicine and Society
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Disaster Response and Management
- Ion Transport and Channel Regulation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Potassium and Related Disorders
- Pediatric Pain Management Techniques
- Liver Disease and Transplantation
- Emergency Medicine Education and Research
- Clinical Reasoning and Diagnostic Skills
Université Côte d'Azur
2014-2024
Hôpital Pasteur
2015-2024
Centre Hospitalier Universitaire de Nice
2014-2023
Observatoire de la Côte d’Azur
2022-2023
Hôpital Saint Roch
2007-2017
Princess Grace Hospital Centre
2017
Délégation Régionale Provence-Alpes-Côte d’Azur et Corse
2013
University of Chicago
2003-2007
American Society of Anesthesiologists
1998
Hôpital Albert Michallon
1998
A prospective study was conducted on 34 stable septic patients to determine whether mild hyperlactatemia is a marker of lactate overproduction or an indicator underutilization during sepsis. Plasma clearance and production were evaluated by modeling the kinetic induced infusion 1 mmol/kg l-lactate over 15 min. The divided in two groups depending their blood lactate: ⩽ 1.5 mmol/L (n = 20, 1.2 ± 0.2 mmol/L) ⩾ 2 10, 2.6 0.6 mmol/L). hyperlactatemic had lower (473 102 ml/kg/h) than those with...
Ischemia-reperfusion injury induces cell death, but the responsible mechanisms are not understood. This study examined mitochondrial depolarization and death during ischemia reperfusion. Contracting cardiomyocytes were subjected to 60-min followed by 3-h Mitochondrial membrane potential (ΔΨ m ) was assessed with tetramethylrhodamine methyl ester. During ischemia, ΔΨ decreased 24 ± 5.5% of baseline, no recovery evident Cell Sytox Green minimal averaged 66 7% after Cyclosporin A, an inhibitor...
Objective To evaluate the prognostic value of lactate clearance and production in severely ill septic patients with normal or mildly elevated blood concentration. Design Prospective, observational study. Setting Nineteen-bed mixed medicosurgical intensive care unit. Patients Fifty-six severe sepsis concentration <3 mmol/L. Measurements Main Results Lactate metabolism was evaluated all patients. measured by modeling change arterial over time induced an infusion 1 mmol/kg sodium for 15 mins....
Objective To evaluate the effect of continuous venovenous hemofiltration with dialysis on lactate elimination by critically ill patients. Design Prospective, clinical study. Setting Surgical intensive care unit a university hospital. Patients Ten patients acute renal failure and stable blood concentrations. Interventions Two-stage investigation: a) measurement concentrations in samples serum ultradiafiltrate from receiving to calculate clearance hemofilter; b) evaluation total plasma...
Urinary tract infections (UTIs) are one of the leading reasons for antibiotic prescriptions in emergency departments (EDs), with half these antibiotics being inappropriately prescribed. Our objective was to assess impact a computerized decision support system (CDSS) on compliance guidelines empirical (antibiotic and duration) UTIs EDs.A multicentre prospective before-and-after controlled interventional study conducted from 19 March 28 October 2012. All adults diagnosed community-acquired...
Background Recent literature reports a strong thrombotic tendency in patients hospitalized for coronavirus disease 2019 (COVID-19) infection. This characteristic is unusual and seems specific to COVID-19 infections, especially their severe form. Viral infections can trigger acquired thrombophilia, which then lead complications. We investigate the presence of could participate this phenomenon, report its prevalence. also wonder if these thrombophilias bad prognosis infections. Methods Results...
Measurement of blood lactate concentration in the early management sepsis is an important step severity assessment. High levels phase have classically been thought to be related tissue hypoxia, but other factors could intervene. We hypothesized that activation glycolysis through β-adrenergic stimulation by endogenous catecholamines plays role production and long-term β-blocker therapy affect patients with severe septic shock.Retrospective cohort study.Emergency department.Two hundred sixty...
Dopamine is widely used to improve systemic and hepatosplanchnic hemodynamics oxygenation during sepsis. However, some studies have suggest that norepinephrine may beneficial effects on regional blood flow metabolism, whereas dopamine might deleterious related redistribution of away from the intestinal mucosa or by decreasing directly cell redox state. In 12 vasoplegic septic patients, we compared hemodynamics, oxygenation, energy metabolism. Catecholamines were administered in a crossover...
Association between Hydroxychloroquine (HCQ) and Azithromycin (AZT) is under evaluation for patients with lower respiratory tract infection (LRTI) caused by the Severe Acute Respiratory Syndrome (SARS-CoV-2). Both drugs have a known torsadogenic potential, but sparse data are available concerning QT prolongation induced this association. Our objective was to assess COVID-19 LRTI variations of interval HCQ/AZT in hospitalized, compare manual versus automated measurements. Before therapy...
Abstract Objectives The goal of our study was to compare the frequency and severity recovery reactions between ketamine ketamine‐propofol 1:1 admixture (“ketofol”). Methods We performed a multicentric, randomized, double‐blind trial in which adult patients received emergency procedural sedations with or ketofol. Our primary outcome proportion unpleasant reactions. Other outcomes were interventions required by these reactions, rates respiratory hemodynamic events, emesis, satisfaction as well...