Abstract Aim This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp . lactis ( B. ) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis. Materials Methods Forty‐one periodontitis were recruited monitored clinically, immunologically, microbiologically at baseline (before SRP) 30 90 days after SRP. All randomly assigned a Test (SRP + Probiotic, n = 20) or Control...

Background: This study evaluates effects of topical administration probiotic bacteria the genus Bifidobacterium on experimental periodontitis (EP) in rats. Methods: Thirty‐two rats were divided into groups C (control; without EP), EP (EP only), C‐HN019 (control+probiotic), and EP‐HN019 (EP+probiotic). On day 0 experiment, animals received cotton ligatures around mandibular first molars (MFMs). In EP‐HN019, 1 mL suspensions containing animalis subsp. lactis ( B. ) HN019 was topically...

Objective To evaluate the effects of Bifidobacterium animalis subsp. lactis HN019 (HN019) on clinical periodontal parameters (plaque accumulation and gingival bleeding), immunocompetence tissues [expression beta-defensin (BD)-3, toll-like receptor 4 (TLR4), cluster differentiation(CD)-57 CD-4], immunological properties saliva (IgA levels) in non-surgical therapy generalized chronic periodontitis (GCP) patients. Adhesion to buccal epithelial cells (BEC) antimicrobial were also investigated....

Lactobacillus probiotics have been investigated in periodontitis. However, the effects of genus Bifidobacterium on periodontitis are hardly known. This study evaluated probiotic (PROB) animalis subsp. lactis (B. lactis) HN019 as an adjunct to scaling and root planing (SRP) rats with experimental (EP). At baseline, 32 were assigned 4 groups: C (control), PROB, EP-SRP EP-SRP-PROB. In groups EP-SRP-PROB, mandibular first molars animals received a ligature. day 14, ligatures removed SRP was...

Chemerin is an adipokine that regulates adipogenesis and metabolic functions of mature adipocytes mainly through the activation chemokine-like receptor 1 (CMKLR1). Elevated levels chemerin have been found in individuals with obesity, type 2 diabetes, osteoporosis. This was identified as inflammatory syndrome marker. Considering association between bone health remains unclear, present study aimed to clarify role pathophysiology loss induced by dyslipidemia, particularly modulating...

Skin wound infection requires carefully long-term treatment with an immense financial burden to healthcare systems worldwide. Various strategies such as drug delivery using polymer matrix from natural source have been used enhance healing. Natural rubber latex (NRL) Hevea brasiliensis has shown angiogenic and tissue repair properties. Gentamicin sulfate (GS) is a broad-spectrum antibiotic which inhibits the growth of wide variety microorganisms and, because this, it also applied topically...

Abstract Aim: The aim of this study was to evaluate the effectiveness a controlled‐released chlorhexidine chip (CHX) as adjunctive therapy scaling and root planing (SRP) in treatment chronic periodontitis. Material methods: Twenty patients with at least four sites probing depth ≥ 5 mm bleeding on were selected. This randomized single‐blind carried out parallel design. control group received SRP alone, while test plus CHX chip. clinical parameters, Plaque Index (PlI), Papillary Bleeding Score...

Halitosis has been correlated with the concentration of volatile sulfur compounds (VSC) produced in oral cavity by metabolic activity bacteria colonizing periodontal area and dorsum tongue. The aim this study was to determine whether there is some relationship between presence N-benzoyl-DL-arginine-2-napthylamide (BANA)-positive species Treponema denticola, Porphyromonas gingivalis, Bacteroides forsythus clinical malodor parameters.Twenty-one subjects (21 59 years old) probing depths (PD) >...

Abstract Objective: Evaluation of the clinical and microbiological effects scaling root planing (SRP) alone or in combination with 0.12% chlorhexidine (CHX) rinsing. Methods: A blind, placebo‐controlled, parallel‐design, randomized trial was conducted 29 subjects chronic periodontitis. Subjects were assigned to two therapeutic groups: control (SRP+placebo) test (SRP+CHX during up 42 days post‐therapy). Clinical [ N ‐benzoyl‐ dl ‐arginine‐2‐naphthylamide (BANA test)] examinations performed at...

The NOD-like receptors are cytoplasmic proteins that sense microbial by-products released by invasive bacteria. Although NOD1 and NOD2 functionally expressed in cells from oral tissues play a role triggering immune responses, the of receptor bone resorption modulation osteoclastogenesis is still unclear. We show an experimental model periodontitis with Porphyromonas gingivalis W83, -/- mice showed lower when compared to wild type. Quantitative polymerase chain reaction analysis revealed...

The purpose of this study was to evaluate the effects systemic administration probiotic Bifidobacterium animalis subsp. lactis HN019 (HN019) on ligature-induced periodontitis in rats with experimental rheumatoid arthritis (RA). 28 were divided into four groups (n=7): RA (rheumatoid arthritis), RA/PROB (probiotic), RA/EP (experimental periodontitis) and RA/EP/PROB. From day zero, added daily water PROB animals until end experiment. seven, induced. On 28, EP groups, ligatures positioned around...

Abstract Aim This randomized placebo‐controlled clinical trial evaluated the effects of multispecies probiotic containing Lactobacillus rhamnosus HN001™, paracasei Lpc‐37®, and Bifidobacterium animalis subsp lactis HN019™ as an adjunct to mechanical debridement (MD) on changes in bleeding probing (BOP) edentulous patients with peri‐implant mucositis (PiM). Materials Methods Patients were randomly assigned test (probiotic) or control (placebo) groups. All sites PiM received MD topical gel...

The limitations of dental irrigation solutions reinforce the need to explore novel bioactive compounds that are safer and biodegradable. This study aimed prepare a 10% pomegranate peel solution (Punica granatum extract - PGE) evaluate its antimicrobial antioxidant effects for root canal treatment.Lyophilized extracts (1g/10 mL) from peels were prepared, punicalagin content was assessed by ultra-performance liquid chromatography using pure (standard). activity tested against common persistent...

Osteoporosis is associated with bone microarchitecture alterations, and the depletion of estrogen during menopause a major contributing factor to its development. The literature highlights noteworthy role gut microbiota in metabolism, particularly progression osteoporosis. Periodontal disease leads alveolar loss, which may be influenced by deficiency, this mechanism intricately an imbalance systemic microbiota. aim study was evaluate effects Bifidobacterium animalis subsp. lactis HN019 (B....

The present study was designed to evaluate the in vitro antimicrobial activity of Copaifera langsdorffii oleoresin, which has been used folk medicine as an anti-inflammatory, antibacterial, healing among others. oleoresin tested against Gram-positive (Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis) and Gram-negative (Pseudomonas aeruginosa Escherichia coli) bacteria related infections cutaneous wounds. Antimicrobial determined by minimum inhibitory concentration (MIC)...

This work aims to improve the functionality of Rosmarinus officinalis L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 23 Box-Wilson central composite design (CCD) was employed determine lone and interaction effects composition variables on moisture content (Xp); water activity (Aw); concentration retention rosemary polyphenols-rosmarinic acid (ROA), carnosol (CAR), carnosic (CNA); recovery spray-dried proliposomes (SDP). Processing conditions which...

Polishing of dental prostheses can cause a dangerous cycle cross-contamination involving dentists, laboratory technicians, patients and auxiliary personnel. The aim this study was to show the microbial contamination in during polishing procedure complete dentures. For purpose, 4 experiments were conducted. Experiment I -- Determination total colony-forming units (CFU) counts contaminating maxillary During procedure, determination CFU transferred operator (Experiment II) previously sterilized...

Abstract Objective In the last decades aroused interest for bone tissue bank as an alternative to autogenous grafting, avoiding donor sites morbidity, surgical time, and costs reduction. The purpose of study was compare allografts ( AL g) with autografts AU using histology, immunochemistry, tomographic analysis. Material methods Fifty‐six New Zealand White rabbits were submitted procedures. Twenty animals donors 36 actually onlay grafting g (experimental group) (control randomly placed...

Abstract Background This study evaluated the effects of topical administration Bdellovibrio bacteriovorus HD100 on experimental periodontitis (EP) in rats. Methods Thirty‐two rats were divided into groups C (control), EP, C‐HD100, and EP‐HD100. At day 0, animals EP EP‐HD100 received cotton ligatures around mandibular first molars (MFM). In C‐HD100 EP‐HD100, 1 mL suspensions containing B. was topically administered subgingival region MFMs at days 3, 7. Animals euthanized 14. Gingival tissue,...