A5034138099- Optical Coherence Tomography Applications
- Paleopathology and ancient diseases
- Photoacoustic and Ultrasonic Imaging
- Forensic Entomology and Diptera Studies
- Conservation Techniques and Studies
- Coronary Interventions and Diagnostics
- Biosimilars and Bioanalytical Methods
- Retinal and Optic Conditions
- Esophageal Cancer Research and Treatment
- Corneal surgery and disorders
- Forensic Anthropology and Bioarchaeology Studies
- Forensic and Genetic Research
- Ocular and Laser Science Research
- AI in cancer detection
- Cultural Heritage Materials Analysis
- Advanced Fluorescence Microscopy Techniques
- Psoriasis: Treatment and Pathogenesis
- Advanced Biosensing Techniques and Applications
- Cell Image Analysis Techniques
- Child Abuse and Related Trauma
- Forensic Fingerprint Detection Methods
- Dermatology and Skin Diseases
- Retinal and Macular Surgery
- Building materials and conservation
- Vascular Malformations Diagnosis and Treatment
University of Amsterdam
2016-2025
Amsterdam University Medical Centers
2018-2025
Public Health Service of Amsterdam
2024-2025
Amsterdam UMC Location University of Amsterdam
2016-2020
Vrije Universiteit Amsterdam
2014-2015
Dried blood spot (DBS) sampling is recognized as a valuable alternative strategy both in research and clinical routine. Although many advantages are associated with DBS sampling, its more widespread use hampered by several issues, of which the hematocrit effect on DBS-based quantitation remains undoubtedly most widely discussed one. Previously, we developed method to derive approximate from nonvolumetrically applied based potassium content. this yielded good results was straightforward...
The hematocrit (Hct) effect is one of the most important hurdles currently preventing more widespread implementation quantitative dried blood spot (DBS) analysis in a routine context. Indeed, Hct may affect both accuracy DBS methods as well interpretation DBS-based results. We previously developed method to determine based on its hemoglobin content using noncontact diffuse reflectance spectroscopy. Despite ease with which can be performed (i.e., mere scanning DBS) and good results that were...
This study investigates the feasibility of in vivo quantitative optical coherence tomography (OCT) human brain tissue during glioma resection surgery six patients. High-resolution detection may allow precise and thorough tumor while preserving functional areas, improving overall survival. In this study, 3D OCT datasets were collected standard surgical procedure, before after partial tumor, both from normal parenchyma. Subsequently, attenuation coefficient was extracted using an automated...
Diagnostic accuracy of needle-based optical coherence tomography (OCT) for prostate cancer detection by visual and quantitative analysis is defined. 106 three-dimensional (3-D)-OCT data sets were acquired in 20 prostates after radical prostatectomy precisely matched with pathology. OCT images grouped per histological category. Two reviewers performed blind assessments the images. Sensitivity specificity malignancy calculated. Quantitative analyses automated attenuation coefficient...
Numerical modeling of postmortem body temperature allows reconstruction the time since death for criminal investigations.
Abstract Determining the time since death, i.e., post-mortem interval (PMI), often plays a key role in forensic investigations. The current standard PMI-estimation method empirically correlates rectal temperatures and PMIs, frequently necessitating subjective correction factors. To overcome this, we previously developed thermodynamic finite-difference (TFD) algorithm, providing rigorous to simulate of bodies assuming straight posture. However, practice, are found non-straight postures,...
Abstract Objectives Knowledge of the physical effects pulsed dye laser (PDL) treatment psoriatic lesions is essential in unraveling remedial mechanisms this and hence also maximizing its disease‐modifying potential. Therefore, main objective study was to provide estimates these (for wavelengths 585 595 nm), with aim identifying pathogenic processes that may be affected by conditions. Methods We modeled light propagation subsequent photothermal heating numerically solving transient diffusion...
Literature on luminescent properties of thermally altered human remains is scarce and contradictory. Therefore, the luminescence heated bone was systemically reinvestigated. A heating experiment conducted fresh bone, in two different media, cremated were recovered from a modern crematory. Luminescence excited with light sources within range 350 to 560 nm. The excitation filtered out by using long pass filters, analysed means scoring method. results show that temperature, duration surrounding...
In this study; an OCT-based intra-operative imaging method for blood flow detection during esophagectomy with gastric tube reconstruction is investigated. Change in perfusion of the tissue can lead to ischemia; a high morbidity and mortality as result. Anastomotic leakage (incidence 5⁻20%) one most severe complications after reconstruction. Optical techniques provide minimal-invasive real-time visualization tools that be used intraoperative settings. By implementing optical technique...
In the forensic field, knowledge about time of deposition semen traces is extremely valuable to law enforcement agencies assess relevance and validity witness testimonies. However, currently, no method exists that able estimate stains, due complex chemistry constituents variation in degradation patterns. Here, we demonstrate a non-contact age estimation stains using fluorescence spectroscopy. Protein–lipid oxidation reactions were monitored over protein fluorescent product signatures reveal...
A taphonomic research facility for the study of human remains was recently realized in Amsterdam, Netherlands, to systematically investigate decomposition body under known conditions. Governmental authorization obtained make use donation program Amsterdam University Medical Centers, location Academic Center, this specific purpose. In contrast small number comparable initiatives elsewhere, specifically allows buried bodies e.g. with telemetry and remote sensing. Here, we discuss concept its...
Optical coherence tomography (OCT), enables high-resolution 3D imaging of the morphology light scattering tissues. From OCT signal, parameters can be extracted and related to tissue structures. One quantitative is attenuation coefficient; rate at which intensity detected decays in depth. To couple with histology one-to-one registration needed. The primary aim this study validate a method histological outcome through histology. We matched images unstained fixated prostate slices corresponding...
In this study, four optical techniques—Optical Coherence Tomography, Sidestream Darkfield Microscopy, Laser Speckle Contrast Imaging, and Fluorescence Angiography (FA)—were compared on performing an intraoperative quantitative perfusion assessment of the gastric conduit during oesophagectomy. We hypothesised that parameters show decreased towards fundus in patients with anastomotic leakage. a prospective study undergoing oesophagectomy reconstruction, measurements were taken all techniques...
This study tests fluorescence imaging-derived quantitative parameters for perfusion evaluation of the gastric tube during surgery and correlates these with patient outcomes in terms anastomotic leakage. Poor fundus is seen as a major factor development leakage strictures. Fluorescence imaging may reduce incidence complications. Parameters quantification signal are still lacking. Quantitative maximal intensity, mean slope influx timepoint were tested significant differences between four areas...
The postmortem interval (PMI), i.e. the time since death, plays a key role in forensic investigations, as it aids reconstruction of timeline events. Currently, standard method for PMI estimation empirically correlates rectal temperatures and PMIs, frequently necessitating subjective correction factors. To address this shortcoming, numerical thermodynamic algorithms have recently been developed, providing rigorous methods to simulate body temperatures. Comparing these with measured then...