A5082333169- Birth, Development, and Health
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gestational Diabetes Research and Management
- Child Nutrition and Water Access
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Genetic Associations and Epidemiology
- Diabetes Management and Research
- Obesity, Physical Activity, Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Skin Diseases and Diabetes
- Dupuytren's Contracture and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Pregnancy and preeclampsia studies
- Exercise and Physiological Responses
- Health and Wellbeing Research
- Healthcare and Venom Research
- Cardiovascular Disease and Adiposity
- Cancer-related molecular mechanisms research
- Physical Activity and Health
- Bariatric Surgery and Outcomes
- Adipose Tissue and Metabolism
- High Altitude and Hypoxia
- Medical Education and Admissions
King Edward Memorial Hospital Research Centre
2021-2025
Symbiosis International University
2023-2025
King Edward Memorial Hospital
2022
Five subgroups were described in European diabetes patients using a data driven machine learning approach on commonly measured variables. We aimed to test the applicability of this phenotyping Indian individuals with young-onset type 2 diabetes.
A machine-learning approach identified five subgroups of diabetes in Europeans which included severe autoimmune (SAID), insulin-deficient (SIDD), insulin-resistant (SIRD), mild obesity-related (MOD) and age-related (MARD) with partially distinct genetic aetiologies. We previously validated four the non-autoimmune people young-onset type 2 (T2D) from Indian WellGen study. Here, we aimed to apply European-derived centroids risk scores (GRSs) unselected (for age) test their applicability...
Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance from one parent or parental bias. Most studies of these phenomena have focused on adult populations. We aimed to investigate the heritability effects cardiometabolic in a birth cohort with serial measurements determine whether patterns emerged early life. The Pune Maternal Nutrition Study comprises offspring parents were studied followed up for 24 years. investigated...
OBJECTIVE India is a double world capital of early-life undernutrition and type 2 diabetes. We aimed to characterize life course growth metabolic trajectories in those developing glucose intolerance as young adults the Pune Maternal Nutrition Study (PMNS). RESEARCH DESIGN AND METHODS PMNS community-based intergenerational birth cohort established 1993, with serial information on parents children through pregnancy, childhood, adolescence. compared normal glucose-tolerant glucose-intolerant...
RCTs of GDM treatment reduces adverse pregnancy outcomes but not long-term offspring diabesity which is influenced by genetic and epigenetic programming. The vital window for programming pre- immediate post-conceptional, strongly maternal nutrition metabolism. Diagnosing later in the systematically misses this window. Metabolic-endocrine abnormalities ‘GDM’ are detectable years before (Catalano 2013; Han 2016). There little data to track life course evolution hyperglycaemia. Pune Maternal...
ABSTRACT Aims/hypothesis Non-autoimmune diabetes in the young is believed to be driven by overweight-obesity and insulin resistance. However, it’s increasingly reported undernourished people LMICs, including India. We hypothesized a role for undernutrition aetiology of non-autoimmune impoverished patients attending Assam Medical College Hospital (AMCH), Dibrugarh (North-East India) treatment. Methods measured socioeconomic status (SES), height body mass index (BMI, kg/m 2 ), waist hip...
ABSTRACT Aim To examine the effect of maternal size and degree hyperglycemia on neonatal adiposity in relatively thin Indian population. Study design Analysis routine clinical data collected one diabetes clinic. Methods We examined association (BMI) (type diabetes, type 1 being thinnest most hyperglycemic, 2 Gestational overweight obese but less hyperglycemic) with measurements (weight, ponderal index, abdominal circumference, skinfold thickness) using multiple linear regression. Results...
Abstract Introduction Hand conditions in diabetes, namely limited joint mobility (LJM), flexor tenosynovitis (FT), carpal tunnel syndrome (CTS), and Dupuytren disease (DD), share a common pathophysiological process involving pro-fibrotic inflammation structures. A unified, quantitative measure of severity across these is lacking, limiting correlational research. We evaluated mean metacarpophalangeal (MCP) extension as potential severity. Methods assessed 2405 adults, including individuals...
Abstract Introduction Gestational diabetes (GDM) increases risk of and obesity (diabesity) in the offspring. However, intensive treatment GDM (generally diagnosed late pregnancy) has failed to reduce these outcomes RCTs. The vital window for programming diabesity is pre- peri-conceptional, influenced by maternal metabolism. Though it known that metabolic-endocrine abnormalities ‘GDM’ may be detectable before pregnancy, there little data on life course precursors pregnancy hyperglycemia....
Abstract The ‘thrifty phenotype’ hypothesis proposed that fetal undernutrition increases risk of diabetes in later life. Undernourished low birthweight Indian babies are paradoxically more adipose compared to well-nourished European babies, and at higher Twin pregnancies an example utero growth restrictive environment due shared maternal nutrition. There few studies body composition twins. We performed secondary analysis anthropometric twins singletons Guinea-Bissau, economically deprived...
Abstract Objective India is a double world capital for early life undernutrition and type 2 diabetes. We aimed to characterise lifecourse growth metabolic trajectories in those developing glucose intolerance as young adults, the Pune Maternal Nutrition Study (PMNS). Research design Methods PMNS community-based intergenerational birth cohort established 1993, with serial information on parents children through pregnancy, childhood adolescence. compared normal tolerant intolerant participants...
Abstract Background Diabetic cheiroarthropathies consist of limited joint mobility (LJM), flexor tenosynovitis (FTS), Dupuytren’s contracture (DC), and carpal tunnel syndrome (CTS). There is heterogeneity in definitions lack a method to measure hand fibrosis load. We measured metacarpophalangeal (MCP) restriction describe magnetic resonance (MR) imaging characteristics across the spectrum restriction. Methods Adults with type 1 diabetes were screened for manifestations using symptom...
Background: Stress level can be estimated by evaluating the malondialdehyde (MDA) levels produced from lipid peroxidation of polyunsaturated fatty acids. Accordingly, a holistic health care approach (instead conventional drug-based alone) for treatment is highly recommended; development mind-body medicine or an inclusive interactions need hour. Thus, effect yoga which comprises pranayama, asana, and meditation more relaxing than well-equipped gym schools today are very lucrative attractive,...
Background: India is the world’s capital of ‘thin-fat’ phenotype and young onset diabetes. Abdominal adiposity a possible explanation. We studied association abdominal fat distribution by MRI with glucose-insulin metabolism. Methods: Young adults [18 years, n=595 (308 boys), PMNS cohort] were classified ADA 75 g OGTT as NGT prediabetic. measured anthropometry, total body (DXA), parameters (HOMA, Insulinogenic Matsuda index), visceral (VAT) subcutaneous (SAT) MRI. Results: Prediabetic boys...
A machine-learning approach identified five subgroups of diabetes in Europeans. We tested the applicability European-derived centroids and genetic risk scores to type 2 its subtypes an unselected cohort Indian ancestry (WellGen, n= 2217, 821 genotyped) compared diabetes-free controls (Pune Maternal Nutrition Study, n = 461). Weighted-GRS for T2D, obesity lipid-related traits associated with T2D. Four were obtained including insulin-deficient SIDD, mild obesity-related MOD, severe...
Abstract Aim/Hypothesis Five subgroups were described in European diabetes patients using a data driven machine learning approach on commonly measured variables. We aimed to test the applicability of this phenotyping Indian young-onset type 2 patients. Methods applied derived centroids diagnosed before 45 years age from WellGen (n = 1612) cohort. also de novo k-means clustering cohort validate subgroups. then compared clinical and metabolic-endocrine characteristics complication rates...
ABSTRACT ‘Thrifty phenotype’ hypothesis proposed that fetal undernutrition increases risk of diabetes in later life. Undernourished low birthweight Indian babies are paradoxically more adipose compared to well-nourished European babies, and at higher Twin pregnancies an example utero growth restrictive environment due shared maternal nutrition. There few studies body composition twins. We performed secondary analysis anthropometric twins singletons Guinea-Bissau, economically deprived...
Abstract Objective Human traits are heritable, and some of these including metabolic lipid phenotypes show preferential parental transmissions, or parent-of-origin effects. These have been mostly studied in populations comprising adults. We aimed to investigate heritability effects on cardiometabolic anthropometric a birth-cohort with serial measurements assess if manifested at an early age. Research design methods investigated the Pune Maternal Nutrition Study (PMNS) wherein offspring...
<i>Objective</i> <p>India is a double world capital for early life undernutrition and type 2 diabetes. We aimed to characterise lifecourse growth metabolic trajectories in those developing glucose intolerance as young adults, the Pune Maternal Nutrition Study (PMNS). </p> <p><i>Research design Methods</i></p> <p>PMNS community-based intergenerational birth cohort established 1993, with serial information on parents children through...