A5107048461- Neuroscience and Neuropharmacology Research
- Dementia and Cognitive Impairment Research
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Intensive Care Unit Cognitive Disorders
- Neuropeptides and Animal Physiology
- Frailty in Older Adults
- Geriatric Care and Nursing Homes
- Anesthesia and Sedative Agents
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Biochemical Analysis and Sensing Techniques
- Parkinson's Disease Mechanisms and Treatments
- Diet and metabolism studies
- Cardiac, Anesthesia and Surgical Outcomes
- Phosphodiesterase function and regulation
- Aging and Gerontology Research
- Health disparities and outcomes
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- Protein Kinase Regulation and GTPase Signaling
Gruppo di Ricerca Geriatrica
2010-2024
University of Rome Tor Vergata
2011-2021
Società Italiana di Fisica
2020-2021
Società Italiana di Medicina Generale
2018
University of Newcastle Australia
2013
Wollongong Hospital
2013
Hebrew SeniorLife
2013
University of South Australia
2013
Beth Israel Deaconess Medical Center
2013
Harvard University
2013
Objective: to evaluate the performance of 4 ‘A’s Test (4AT) in screening for delirium older patients. The 4AT is a new test rapid routine clinical practice. Design: prospective study consecutively admitted elderly patients with independent and reference standard assessments. Setting: an acute geriatrics ward department rehabilitation. Participants: two hundred thirty-six (aged ≥70 years) over period months. Measurements: each centre, was administered by geriatrician eligible within 24 h...
The Mini‐Mental State Examination (MMSE), a brief test to assess cognitive status, is heavily influenced by age and education. It was administered 1019 elderly subjects (aged 65–89 years) living in three different Italian cities. A statistical non‐linear regression model built up order obtain adjustment coefficients reduce the influence of demographic variables on MMSE raw scores. Age educational level were significantly independently associated with score. Results multiple linear...
The relation between changes in brain and plasma concentrations of neurosteroids the function structure γ-aminobutyric acid type A (GABA ) receptors during pregnancy after delivery was investigated rats. In contrast with plasma, where all steroids increased parallel, kinetics cerebrocortical progesterone, allopregnanolone (AP), allotetrahydrodeoxycorticosterone (THDOC) diverged pregnancy. Progesterone already maximally days 10 15, whereas AP peaked around day 19. stimulatory effect muscimol...
Background Music therapy (MT) has been proposed as valid approach for behavioral and psychologic symptoms (BPSD) of dementia. However, studies demonstrating the effectiveness this are lacking. Objective To assess MT in reducing BPSD subjects with Method Fifty-nine persons dementia were enrolled study. All them underwent a multidimensional assessment including Mini Mental State Examination, Barthel Index Neuropsychiatry Inventory at enrolment after 8, 16, 20 weeks. Subjects randomly assigned...
No studies analyzing the role of dementia as a risk factor for mortality in patients affected by COVID-19. We assessed prevalence, clinical presentation and outcomes among subjects hospitalized COVID19 infection.
To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number participants these not exceeded a few hundred. overcome limitations, we have determined, multicenter study, over single day large population patients admitted to and rehabilitation wards Italy. This is point study (called "Delirium Day") including 1867 older (aged 65 years or more) across...
The time courses of changes in rat brain neuroactive steroid concentrations and γ-aminobutyric acid type A (GABAA) receptor function elicited by acute stress were investigated animals exposed to CO2 for 1 min, a treatment known induce rats panic attacks humans. Inhalation induced increases cerebral cortical concentrations, the dependence which varied with examined. Thus, progesterone deoxycorticosterone showed maximal (10- 4-fold, respectively) 10 min after inhalation had returned basal...
To describe atrophic changes of the hippocampus and entorhinal cortex in frontotemporal dementia (FTD) compare them with those AD.The medial temporal lobe shows early course AD, but whether these are specific to AD or occur other degenerative dementias, what extent, is unclear.The authors measured volumes left right from MR images (1.5 T, 2-mm-thick slices) 12 patients FTD, 30 elderly control subjects.In FTD patients, (16% 21% tissue loss) (28% 27% were more than subjects. Atrophy was less...
To assess noun and verb processing in different dementia types, we tested object action naming three groups of subjects: probable Alzheimer's disease (AD) with mild to moderate dementia; age- education-matched normal subjects; a group frontotemporal (FTD) patients. AD FTD patients were impaired compared control was more severely impaired. However, the discrepancy between significantly greater than patients, independent severity or overall language impairment. The latter finding is compatible...
This study was undertaken to investigate the relationship between a reduction in brain GABA A receptor function and cerebro‐cortical content of 3α‐hydroxy‐5α‐pregnan‐20 one (allopregnanolone, AP), potent endogenous positive modulator γ‐aminobutyric acid (GABA) action at receptors, with anticonflict anticonvulsant effects rodents. An acute depletion cerebral or an attenuation receptor‐mediated transmission by systemic injections isoniazid (375 mg kg −1 , s.c.) FG 7142 (15 i.p.) induced...
To test the hypothesis of opiate-like peptide release after transcutaneous electrotherapy we measured β-endorphin cerebrospinal fluid (CSF) content in 13 patients without pain problems. The results indicate a time dependent increase CSF group studied. This fact suggests that analgesic properties treatment may be ascribed to an involvement endogenous opiates system, independently from basal clinical conditions patients.
Nigral basal adenylate cyclase and dopamine-sensitive cyclase, glutamate decarboxylase, choline acetyltransferase, tyrosine hydroxylase activities were measured in rats with hemitransections at various levels or electrolytic lesions of the medial forebrain bundle crus cerebri. The loss nigral activity after brain was correlated glutamic acid decarboxylase but not that hydroxylase; acetyltransferase unaffected all cases. data indicate cylase may be localized on neurons afferent to nigra,...
The tragic events in Italy, with more than 10 000 deaths due to novel coronavirus 2019 (COVID-19), are causing pain and demoralisation a still incredulous shocked general population. It is particularly distressing that outbreaks of infection have developed rapidly many nursing homes, where staff been completely neglected by health authorities can offer only little protection frail needy older people. In the province Bergamo, 600 home residents, from total capacity 6400 beds, died between...
BackgroundThere is little evidence about the prevalence of cognitive disorders and their effect on in-hospital mortality in large multicenter studies. The objectives 2016th edition “Italian Delirium Day,” a study older patients, were to assess (i) point impairment/no dementia, delirium, delirium superimposed dementia (ii) these conditions mortality.
Italy has been hit very hard by the severe acute respiratory syndrome—coronavirus-2 (SARS-CoV-2) pandemic. This brief report highlights some of peculiarities manifested its older adult population, with particular reference to those living in nursing institutions and at home. Mortality data (as 26 April) are reported, together reactions forced isolation, loneliness, fear contracting disease, which represent big challenges for all, especially frail elderly people.